BR112022016432A2 - Compostos heterocíclicos de heteroarila e usos dos mesmos - Google Patents
Compostos heterocíclicos de heteroarila e usos dos mesmosInfo
- Publication number
- BR112022016432A2 BR112022016432A2 BR112022016432A BR112022016432A BR112022016432A2 BR 112022016432 A2 BR112022016432 A2 BR 112022016432A2 BR 112022016432 A BR112022016432 A BR 112022016432A BR 112022016432 A BR112022016432 A BR 112022016432A BR 112022016432 A2 BR112022016432 A2 BR 112022016432A2
- Authority
- BR
- Brazil
- Prior art keywords
- heteroaryl compounds
- same
- heterocyclic compounds
- heteroaryl
- heteroaryl heterocyclic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
COMPOSTOS HETEROCÍCLICOS DE HETEROARILA E USOS DOS MESMOS. A presente invenção se refere a compostos heterocíclicos de heteroarila da fórmula (I), composições farmacêuticas que compreendem os mesmos, métodos para preparar os mesmos e uso dos mesmos, em que as variáveis são conforme definido na descrição.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010104062 | 2020-02-20 | ||
CN202110169142 | 2021-02-07 | ||
PCT/CN2021/076869 WO2021164735A1 (en) | 2020-02-20 | 2021-02-19 | Heteroaryl heterocyclic compounds and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022016432A2 true BR112022016432A2 (pt) | 2022-11-16 |
Family
ID=77390445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022016432A BR112022016432A2 (pt) | 2020-02-20 | 2021-02-19 | Compostos heterocíclicos de heteroarila e usos dos mesmos |
Country Status (14)
Country | Link |
---|---|
US (2) | US11478474B2 (pt) |
EP (1) | EP4107154A4 (pt) |
JP (1) | JP2023515099A (pt) |
KR (1) | KR20220158712A (pt) |
CN (1) | CN115151535A (pt) |
AU (1) | AU2021222197A1 (pt) |
BR (1) | BR112022016432A2 (pt) |
CA (1) | CA3171012A1 (pt) |
CL (1) | CL2022002255A1 (pt) |
IL (1) | IL295589A (pt) |
MX (1) | MX2022010219A (pt) |
PE (1) | PE20221592A1 (pt) |
TW (1) | TW202140488A (pt) |
WO (1) | WO2021164735A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3171012A1 (en) * | 2020-02-20 | 2021-08-26 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
KR20230104125A (ko) | 2020-09-21 | 2023-07-07 | 허치슨 메디파르마 리미티드 | 헤테로아릴 헤테로사이클릭 화합물 및 이의 용도 |
WO2023143491A1 (zh) * | 2022-01-28 | 2023-08-03 | 和记黄埔医药(上海)有限公司 | 7,8-二氢-2h-环戊二烯并吡咯并吡嗪酮化合物的合成方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2552681T3 (es) | 2008-07-15 | 2015-12-01 | F. Hoffmann-La Roche Ag | Nuevas fenil-imidazopiridinas y piridazinas |
ES2573716T3 (es) | 2010-05-07 | 2016-06-09 | Gilead Connecticut, Inc. | Compuestos de piridona y aza-piridona y métodos de utilización |
UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
WO2013067260A1 (en) * | 2011-11-03 | 2013-05-10 | Genentech, Inc. | Bicyclic piperazine compounds |
AU2012332368A1 (en) | 2011-11-03 | 2014-05-22 | F. Hoffmann-La Roche Ag | Alkylated piperazine compounds as inhibitors of Btk activity |
JP5976826B2 (ja) | 2011-11-03 | 2016-08-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Btk活性阻害剤としての8−フルオロフタラジン−1(2h)−オン化合物 |
JP5832664B2 (ja) | 2011-12-09 | 2015-12-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトン型チロシンキナーゼの阻害剤 |
EP3016943B1 (en) * | 2013-07-03 | 2019-08-21 | F. Hoffmann-La Roche AG | Heteroaryl pyridone and aza-pyridone amide compounds |
JP6275846B2 (ja) * | 2013-12-05 | 2018-02-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物 |
CN106922146B (zh) | 2014-10-02 | 2020-05-26 | 豪夫迈·罗氏有限公司 | 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物 |
WO2016057500A1 (en) | 2014-10-06 | 2016-04-14 | Merck Patent Gmbh | Heteroaryl compounds as btk inhibitors and uses thereof |
US10266528B2 (en) | 2016-08-16 | 2019-04-23 | Merck Patent Gmbh | 2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof |
TWI673271B (zh) | 2016-12-15 | 2019-10-01 | 瑞士商赫孚孟拉羅股份公司 | 製備btk抑制劑之方法 |
UY37559A (es) * | 2017-01-06 | 2018-05-31 | Pharmacyclics Llc | Pirazolo[3,4-b]piridina y pirrolo[2,3-b]piridina como inhibidores de la tirosina quinasa de bruton |
US11100492B2 (en) | 2018-02-19 | 2021-08-24 | Peter Garrett | General purpose re-loadable card aggregation implementation |
CN110256446B (zh) * | 2018-08-01 | 2021-12-14 | 上海海雁医药科技有限公司 | 苯并杂环取代的环戊二烯并[4,5]吡咯并吡嗪-1-酮衍生物及其应用 |
CA3171012A1 (en) * | 2020-02-20 | 2021-08-26 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
-
2021
- 2021-02-19 CA CA3171012A patent/CA3171012A1/en active Pending
- 2021-02-19 TW TW110105765A patent/TW202140488A/zh unknown
- 2021-02-19 IL IL295589A patent/IL295589A/en unknown
- 2021-02-19 EP EP21756469.9A patent/EP4107154A4/en active Pending
- 2021-02-19 WO PCT/CN2021/076869 patent/WO2021164735A1/en unknown
- 2021-02-19 AU AU2021222197A patent/AU2021222197A1/en active Pending
- 2021-02-19 PE PE2022001746A patent/PE20221592A1/es unknown
- 2021-02-19 KR KR1020227032457A patent/KR20220158712A/ko unknown
- 2021-02-19 MX MX2022010219A patent/MX2022010219A/es unknown
- 2021-02-19 JP JP2022550035A patent/JP2023515099A/ja active Pending
- 2021-02-19 BR BR112022016432A patent/BR112022016432A2/pt unknown
- 2021-02-19 CN CN202180015458.2A patent/CN115151535A/zh active Pending
- 2021-10-20 US US17/506,220 patent/US11478474B2/en active Active
-
2022
- 2022-08-18 CL CL2022002255A patent/CL2022002255A1/es unknown
- 2022-08-31 US US17/823,889 patent/US20230043030A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220125785A1 (en) | 2022-04-28 |
AU2021222197A1 (en) | 2022-09-08 |
CN115151535A (zh) | 2022-10-04 |
TW202140488A (zh) | 2021-11-01 |
US20230043030A1 (en) | 2023-02-09 |
CL2022002255A1 (es) | 2023-03-10 |
EP4107154A1 (en) | 2022-12-28 |
CA3171012A1 (en) | 2021-08-26 |
PE20221592A1 (es) | 2022-10-10 |
US11478474B2 (en) | 2022-10-25 |
KR20220158712A (ko) | 2022-12-01 |
JP2023515099A (ja) | 2023-04-12 |
EP4107154A4 (en) | 2024-02-28 |
MX2022010219A (es) | 2022-09-19 |
IL295589A (en) | 2022-10-01 |
WO2021164735A1 (en) | 2021-08-26 |
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