BR112023007528A2 - Uma sonda raman e aparelho e método para medição in vivo não invasiva da presença ou concentração do analito - Google Patents

Uma sonda raman e aparelho e método para medição in vivo não invasiva da presença ou concentração do analito

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Publication number
BR112023007528A2
BR112023007528A2 BR112023007528A BR112023007528A BR112023007528A2 BR 112023007528 A2 BR112023007528 A2 BR 112023007528A2 BR 112023007528 A BR112023007528 A BR 112023007528A BR 112023007528 A BR112023007528 A BR 112023007528A BR 112023007528 A2 BR112023007528 A2 BR 112023007528A2
Authority
BR
Brazil
Prior art keywords
invasive
vivo measurement
concentration
detector
raman probe
Prior art date
Application number
BR112023007528A
Other languages
English (en)
Inventor
John Gibson Joshua
Schjoldager Nielsen Martin
james watson Thomas
Original Assignee
Rsp Systems As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rsp Systems As filed Critical Rsp Systems As
Publication of BR112023007528A2 publication Critical patent/BR112023007528A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G01J2003/102—Plural sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J2003/4424—Fluorescence correction for Raman spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Signal Processing (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Semiconductor Lasers (AREA)

Abstract

uma sonda raman e aparelho e método para medição in vivo não invasiva da presença ou concentração do analito. a presente invenção refere-se a um aparelho e método para medição in vivo não invasiva, por espectroscopia raman, de glicose presente em fluido intersticial na pele de um indivíduo. o aparelho compreende pelo menos um detector; uma pluralidade de lasers de emissão de superfície de cavidade vertical espacialmente distribuídos em torno do pelo menos um detector, para irradiar a pele de um indivíduo; em que o pelo menos um detector é configurado para receber radiação dispersa de raman transmitida da amostra em resposta à radiação recebida dos lasers de emissão de superfície de cavidade vertical.
BR112023007528A 2020-10-23 2021-10-22 Uma sonda raman e aparelho e método para medição in vivo não invasiva da presença ou concentração do analito BR112023007528A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2016873.8A GB2600152A (en) 2020-10-23 2020-10-23 Apparatus and method for non-invasive in vivo measurements of analyte presence or concentration
PCT/EP2021/079414 WO2022084539A2 (en) 2020-10-23 2021-10-22 A raman probe and apparatus and method for non-invasive in vivo measurement of analyte presence or concentration

Publications (1)

Publication Number Publication Date
BR112023007528A2 true BR112023007528A2 (pt) 2023-10-31

Family

ID=73726962

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023007528A BR112023007528A2 (pt) 2020-10-23 2021-10-22 Uma sonda raman e aparelho e método para medição in vivo não invasiva da presença ou concentração do analito

Country Status (10)

Country Link
US (1) US20240003741A1 (pt)
EP (1) EP4231897A2 (pt)
JP (1) JP2023550206A (pt)
KR (1) KR20230121041A (pt)
CN (1) CN116669629A (pt)
AU (1) AU2021366334A1 (pt)
BR (1) BR112023007528A2 (pt)
CA (1) CA3196380A1 (pt)
GB (2) GB2600152A (pt)
WO (1) WO2022084539A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2618817B (en) * 2022-05-18 2024-08-14 Sony Interactive Entertainment Inc Biometric system and method
GB2618846A (en) * 2022-05-20 2023-11-22 Ams Int Ag Optical module
WO2024099542A1 (en) * 2022-11-08 2024-05-16 Spiden Ag Integrated device for spatially offset raman spectroscopy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6816241B2 (en) * 2000-09-26 2004-11-09 Sensys Medical, Inc. LED light source-based instrument for non-invasive blood analyte determination
JP4041421B2 (ja) * 2003-03-25 2008-01-30 独立行政法人理化学研究所 ラマンプローブ及びそれを用いたラマン散乱計測装置
GB0426993D0 (en) 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
GB201000179D0 (en) 2010-01-07 2010-02-24 Rsp Systems As Apparatus for non-invasive in vivo measurement by raman spectroscopy
US20140171759A1 (en) * 2012-02-15 2014-06-19 Craig William WHITE Noninvasive determination of intravascular and exctravascular hydration using near infrared spectroscopy
JP5712337B2 (ja) * 2012-12-27 2015-05-07 パナソニック株式会社 被検物質を検出する方法、および、検出システム
GB201415671D0 (en) 2014-09-04 2014-10-22 Systems Rsp As Method and apparatus for transdermal in vivo measurement by raman spectroscopy
GB201511696D0 (en) 2015-07-03 2015-08-19 Cobalt Light Systems Ltd Scanner for spatially offset raman spectrscopy
CN106247741A (zh) 2016-07-12 2016-12-21 青岛海尔股份有限公司 一种冰箱
GB2557311B (en) 2016-12-06 2021-05-12 Rsp Systems As Analyte Detection apparatus and method of detecting an analyte
US10684226B2 (en) * 2018-03-09 2020-06-16 Samsung Electronics Co., Ltd. Raman probe, Raman spectrum obtaining apparatus, and method of obtaining Raman spectrum and detecting distribution of target material using Raman probe
WO2020191347A1 (en) * 2019-03-21 2020-09-24 Dawatek, Llc Offset raman imaging system and methods of use
KR20210075648A (ko) * 2019-12-13 2021-06-23 삼성전자주식회사 소형 라만 센서 및 생체성분 추정 장치
GB202104630D0 (en) * 2021-03-31 2021-05-12 ams Sensors Germany GmbH Optical module

Also Published As

Publication number Publication date
US20240003741A1 (en) 2024-01-04
WO2022084539A3 (en) 2022-06-16
GB2600152A (en) 2022-04-27
JP2023550206A (ja) 2023-11-30
GB2616989A (en) 2023-09-27
WO2022084539A2 (en) 2022-04-28
AU2021366334A1 (en) 2023-06-08
CN116669629A (zh) 2023-08-29
CA3196380A1 (en) 2022-04-28
AU2021366334A9 (en) 2024-06-13
GB202307663D0 (en) 2023-07-05
EP4231897A2 (en) 2023-08-30
GB202016873D0 (en) 2020-12-09
KR20230121041A (ko) 2023-08-17

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