BR112023006989A2 - Anticorpos biespecíficos anti-pd-1/cd40 e usos dos mesmos - Google Patents
Anticorpos biespecíficos anti-pd-1/cd40 e usos dos mesmosInfo
- Publication number
- BR112023006989A2 BR112023006989A2 BR112023006989A BR112023006989A BR112023006989A2 BR 112023006989 A2 BR112023006989 A2 BR 112023006989A2 BR 112023006989 A BR112023006989 A BR 112023006989A BR 112023006989 A BR112023006989 A BR 112023006989A BR 112023006989 A2 BR112023006989 A2 BR 112023006989A2
- Authority
- BR
- Brazil
- Prior art keywords
- antigen
- bispecific antibodies
- antibodies
- binding protein
- protein constructs
- Prior art date
Links
- 101150013553 CD40 gene Proteins 0.000 title 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000025171 antigen binding proteins Human genes 0.000 abstract 2
- 108091000831 antigen binding proteins Proteins 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
anticorpos biespecíficos anti-pd-1/cd40 e usos dos mesmos. esta divulgação refere-se a construtos de proteína de ligação ao antígeno (por exemplo, anticorpos biespecíficos ou fragmentos de ligação ao antígeno dos mesmos), em que os construtos de proteína de ligação ao antígeno se ligam especificamente a dois antígenos diferentes (por exemplo, pd-1 e cd40).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2020120918 | 2020-10-14 | ||
CN2021085335 | 2021-04-02 | ||
PCT/CN2021/123438 WO2022078357A1 (en) | 2020-10-14 | 2021-10-13 | Anti-pd-1/cd40 bispecific antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023006989A2 true BR112023006989A2 (pt) | 2024-01-02 |
Family
ID=81207517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023006989A BR112023006989A2 (pt) | 2020-10-14 | 2021-10-13 | Anticorpos biespecíficos anti-pd-1/cd40 e usos dos mesmos |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230220082A1 (pt) |
EP (1) | EP4229096A4 (pt) |
JP (1) | JP2023545521A (pt) |
KR (1) | KR20230092932A (pt) |
CN (1) | CN116390755A (pt) |
AU (1) | AU2021359495A1 (pt) |
BR (1) | BR112023006989A2 (pt) |
CA (1) | CA3197463A1 (pt) |
IL (1) | IL302042A (pt) |
MX (1) | MX2023004275A (pt) |
WO (1) | WO2022078357A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117624372A (zh) * | 2022-08-26 | 2024-03-01 | 北京天广实生物技术股份有限公司 | 靶向cd40和pd-l1的抗体及其用途 |
CN116023495B (zh) * | 2022-09-05 | 2023-10-03 | 上海百英生物科技股份有限公司 | 一种抗cd40纳米抗体及其制备方法与应用 |
WO2024059901A1 (en) * | 2022-09-20 | 2024-03-28 | Currus Biologics Pty Ltd | A method of rescuing exhausted immune cells |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180327496A1 (en) * | 2016-11-02 | 2018-11-15 | Apexigen, Inc. | Anti-cd40 antibodies in combination and methods of use |
IL276675B2 (en) * | 2018-02-23 | 2023-10-01 | Eucure Beijing Biopharma Co Ltd | Anti-PD-1 antibodies and uses thereof |
EP3823987A4 (en) * | 2018-07-20 | 2022-03-02 | Eucure (Beijing) Biopharma Co., Ltd | ANTI-CD40 ANTIBODIES AND THEIR USES |
WO2020102233A1 (en) * | 2018-11-13 | 2020-05-22 | Jn Biosciences Llc | Bispecific antibodies for activation of immune cells |
KR20220103957A (ko) * | 2019-10-23 | 2022-07-25 | 리브젠 바이오파마 홀딩스 리미티드 | 항-cd40 결합 분자 및 이를 포함하는 이중-특이적 항체 |
-
2021
- 2021-10-13 AU AU2021359495A patent/AU2021359495A1/en active Pending
- 2021-10-13 EP EP21879400.6A patent/EP4229096A4/en active Pending
- 2021-10-13 JP JP2023523084A patent/JP2023545521A/ja active Pending
- 2021-10-13 BR BR112023006989A patent/BR112023006989A2/pt unknown
- 2021-10-13 IL IL302042A patent/IL302042A/en unknown
- 2021-10-13 MX MX2023004275A patent/MX2023004275A/es unknown
- 2021-10-13 CA CA3197463A patent/CA3197463A1/en active Pending
- 2021-10-13 KR KR1020237014700A patent/KR20230092932A/ko unknown
- 2021-10-13 WO PCT/CN2021/123438 patent/WO2022078357A1/en active Application Filing
- 2021-10-13 CN CN202180069673.0A patent/CN116390755A/zh active Pending
-
2023
- 2023-01-05 US US18/150,428 patent/US20230220082A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230220082A1 (en) | 2023-07-13 |
JP2023545521A (ja) | 2023-10-30 |
CN116390755A (zh) | 2023-07-04 |
KR20230092932A (ko) | 2023-06-26 |
EP4229096A1 (en) | 2023-08-23 |
MX2023004275A (es) | 2023-05-02 |
CA3197463A1 (en) | 2022-04-21 |
IL302042A (en) | 2023-06-01 |
WO2022078357A1 (en) | 2022-04-21 |
AU2021359495A1 (en) | 2023-04-13 |
EP4229096A4 (en) | 2024-06-12 |
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