BR112023003815A2 - Uma toxina da exotoxina estafilocócica b (seb) desintoxicada, antígeno de vacina protetora e preparação de vacina, é utilizada na prevenção ou tratamento de uma infecção bacteriana expressando superantígeno estafilocócico, método de produção da toxina seb desintoxicada, molécula de ácido nucleico que codifica a toxina seb desintoxicada, célula hospedeira recombinante compreendendo a molécula de ácido nucleico - Google Patents
Uma toxina da exotoxina estafilocócica b (seb) desintoxicada, antígeno de vacina protetora e preparação de vacina, é utilizada na prevenção ou tratamento de uma infecção bacteriana expressando superantígeno estafilocócico, método de produção da toxina seb desintoxicada, molécula de ácido nucleico que codifica a toxina seb desintoxicada, célula hospedeira recombinante compreendendo a molécula de ácido nucleicoInfo
- Publication number
- BR112023003815A2 BR112023003815A2 BR112023003815A BR112023003815A BR112023003815A2 BR 112023003815 A2 BR112023003815 A2 BR 112023003815A2 BR 112023003815 A BR112023003815 A BR 112023003815A BR 112023003815 A BR112023003815 A BR 112023003815A BR 112023003815 A2 BR112023003815 A2 BR 112023003815A2
- Authority
- BR
- Brazil
- Prior art keywords
- seb
- toxin
- detoxified
- acid molecule
- staphylococcal
- Prior art date
Links
- 231100000765 toxin Toxicity 0.000 title abstract 9
- 239000003053 toxin Substances 0.000 title abstract 9
- 229960005486 vaccine Drugs 0.000 title abstract 4
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 title abstract 3
- 231100000776 exotoxin Toxicity 0.000 title abstract 3
- 239000002095 exotoxin Substances 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 230000001681 protective effect Effects 0.000 title abstract 2
- 231100000617 superantigen Toxicity 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 108700012359 toxins Proteins 0.000 abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
uma toxina da exotoxina estafilocócica b (seb) desintoxicada, antígeno de vacina protetora e preparação de vacina, é utilizada na prevenção ou tratamento de uma infecção bacteriana expressando superantígeno estafilocócico, método de produção da toxina seb desintoxicada, molécula de ácido nucleico que codifica a toxina seb desintoxicada, célula hospedeira recombinante compreendendo a molécula de ácido nucleico. a presente invenção se refere a uma toxina de exotoxina b (seb) estafilocócica desintoxicada que é mutada para compreender pelo menos duas mutações pontuais nas posições de aminoácidos 21 a 25 na sequência da toxina seb seq id no:1, em que as referidas pelo menos duas mutações pontuais compreendem uma deleção de qualquer uma das aa21-22, aa22-23, aa23-24, aa24-25, aa21-23, aa22-24 ou aa23-25, ou em posições de aminoácidos correspondentes em qualquer outra sequência de toxina seb de ocorrência natural que tenha pelo menos 95% de identidade de sequência com a seq id no:1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20215489 | 2020-12-18 | ||
| PCT/EP2021/080540 WO2022128243A1 (en) | 2020-12-18 | 2021-11-03 | Protective staphylococcal exotoxin vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023003815A2 true BR112023003815A2 (pt) | 2023-10-24 |
Family
ID=73855806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023003815A BR112023003815A2 (pt) | 2020-12-18 | 2021-11-03 | Uma toxina da exotoxina estafilocócica b (seb) desintoxicada, antígeno de vacina protetora e preparação de vacina, é utilizada na prevenção ou tratamento de uma infecção bacteriana expressando superantígeno estafilocócico, método de produção da toxina seb desintoxicada, molécula de ácido nucleico que codifica a toxina seb desintoxicada, célula hospedeira recombinante compreendendo a molécula de ácido nucleico |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230104241A1 (pt) |
| EP (1) | EP4081534B1 (pt) |
| JP (1) | JP2023512344A (pt) |
| KR (1) | KR20220132641A (pt) |
| CN (1) | CN115427433A (pt) |
| BR (1) | BR112023003815A2 (pt) |
| WO (1) | WO2022128243A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023247747A1 (en) * | 2022-06-23 | 2023-12-28 | Biomedizinische Forschung & Bio-Produkte AG | Protective staphylococcal exotoxin vaccine |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08500328A (ja) * | 1992-01-28 | 1996-01-16 | ナショナル ジューイッシュ センター フォア イミュノロジィ アンド レスパラトリィ メディスン | 突然変異したスーパー抗原の保護作用 |
| US6713284B2 (en) | 1997-06-25 | 2004-03-30 | The United States Of America As Represented By The Secretary Of The Army | Bacterial superantigen vaccines |
| AU746372B2 (en) | 1998-02-15 | 2002-04-18 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Novel preventives/remedies for immunopathy |
| EP1461433A1 (en) * | 2001-11-26 | 2004-09-29 | U.S. Medical Research Institute of Infectious Diseases | Bacterial superantigen vaccines |
| WO2005023853A1 (ja) * | 2003-09-05 | 2005-03-17 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | プロテアーゼ耐性ｓｅｂ改変体およびそれを含むワクチン |
| US7576183B2 (en) * | 2003-12-24 | 2009-08-18 | Los Alamos National Security, Llc | Structure-based receptor MIMICS targeted against bacterial superantigen toxins |
| CN103965302B (zh) * | 2013-01-29 | 2019-05-28 | 军事科学院军事医学研究院微生物流行病研究所 | 一种重组超抗原seb突变体，其制备方法及应用 |
| PT3010535T (pt) | 2013-06-19 | 2020-07-03 | Integrated Biotherapeutics Inc | Péptidos de toxoide derivados de modulina solúvel em fenol, delta toxina, superantigénios e suas fusões |
| CN103694321B (zh) * | 2013-12-09 | 2015-11-18 | 重庆原伦生物科技有限公司 | 金黄色葡萄球菌mSEB突变体及其制备方法和应用 |
-
2021
- 2021-11-03 CN CN202180024042.7A patent/CN115427433A/zh active Pending
- 2021-11-03 BR BR112023003815A patent/BR112023003815A2/pt unknown
- 2021-11-03 US US17/910,263 patent/US20230104241A1/en active Pending
- 2021-11-03 JP JP2022563190A patent/JP2023512344A/ja not_active Ceased
- 2021-11-03 KR KR1020227030419A patent/KR20220132641A/ko active IP Right Grant
- 2021-11-03 EP EP21798731.2A patent/EP4081534B1/en active Active
- 2021-11-03 WO PCT/EP2021/080540 patent/WO2022128243A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN115427433A (zh) | 2022-12-02 |
| US20230104241A1 (en) | 2023-04-06 |
| EP4081534C0 (en) | 2023-06-28 |
| EP4081534A1 (en) | 2022-11-02 |
| EP4081534B1 (en) | 2023-06-28 |
| WO2022128243A1 (en) | 2022-06-23 |
| KR20220132641A (ko) | 2022-09-30 |
| JP2023512344A (ja) | 2023-03-24 |
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