BR112023003144A2 - Derivado de pirrolopiridina e uso do mesmo - Google Patents
Derivado de pirrolopiridina e uso do mesmoInfo
- Publication number
- BR112023003144A2 BR112023003144A2 BR112023003144A BR112023003144A BR112023003144A2 BR 112023003144 A2 BR112023003144 A2 BR 112023003144A2 BR 112023003144 A BR112023003144 A BR 112023003144A BR 112023003144 A BR112023003144 A BR 112023003144A BR 112023003144 A2 BR112023003144 A2 BR 112023003144A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolopyridine derivative
- present
- hiv
- pyrrolopyridine
- derivative
- Prior art date
Links
- 150000005255 pyrrolopyridines Chemical class 0.000 title abstract 3
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADO DE PIRROLOPIRIDINA E USO DO MESMO. A presente invenção se refere a um derivado de pirrolopiridina, um racemato do mesmo, um estereoisômero do mesmo ou um sal farmaceuticamente aceitável do mesmo, e uso do mesmo. O composto da presente invenção apresenta alta seletividade e bioatividade contra vírus da imunodeficiência humana (HIV) e baixa toxicidade, sendo assim particularmente útil como agente terapêutico para infecção por HIV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200104758A KR20220023187A (ko) | 2020-08-20 | 2020-08-20 | 피롤로피리딘 유도체 및 이들의 용도 |
| PCT/KR2021/011116 WO2022039551A1 (ko) | 2020-08-20 | 2021-08-20 | 피롤로피리딘 유도체 및 이들의 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023003144A2 true BR112023003144A2 (pt) | 2023-04-04 |
Family
ID=80323119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023003144A BR112023003144A2 (pt) | 2020-08-20 | 2021-08-20 | Derivado de pirrolopiridina e uso do mesmo |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230373994A1 (pt) |
| EP (1) | EP4201405A1 (pt) |
| JP (1) | JP2023538582A (pt) |
| KR (1) | KR20220023187A (pt) |
| CN (1) | CN115916345A (pt) |
| AU (1) | AU2021327616B2 (pt) |
| BR (1) | BR112023003144A2 (pt) |
| WO (1) | WO2022039551A1 (pt) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007534739A (ja) * | 2004-04-26 | 2007-11-29 | ファイザー・インク | ピロロピリジン誘導体及びｈｉｖインテグラーゼ酵素阻害剤としてのその使用 |
| GB0710528D0 (en) * | 2007-06-01 | 2007-07-11 | Glaxo Group Ltd | Novel compounds |
| AU2012209373A1 (en) * | 2011-01-24 | 2013-04-11 | Glaxosmithkline Llc | Isoquinoline compounds and methods for treating HIV |
| ES2624984T3 (es) * | 2011-07-15 | 2017-07-18 | Viiv Healthcare Uk Limited | Derivados de ácido 2-(pirrolo[2,3-b]piridin-5-il)-2-(t-butoxi)-acético como inhibidores de la replicación del VIH para el tratamiento del SIDA |
| JP5893156B2 (ja) * | 2011-11-15 | 2016-03-23 | コリア リサーチ インスティテュート オブ ケミカル テクノロジー | 新規な抗ウイルス性ピロロピリジン誘導体及びその製造方法 |
| KR101592370B1 (ko) * | 2014-06-09 | 2016-02-11 | 한국화학연구원 | 신규한 피롤로피리딘 유도체 및 이의 hiv 저해제로서의 용도 |
| CN110461837B (zh) * | 2017-03-24 | 2022-06-17 | St制药株式会社 | 新型吡咯并吡啶衍生物、其制备方法及用途 |
-
2020
- 2020-08-20 KR KR1020200104758A patent/KR20220023187A/ko unknown
-
2021
- 2021-08-20 WO PCT/KR2021/011116 patent/WO2022039551A1/ko unknown
- 2021-08-20 US US18/021,930 patent/US20230373994A1/en active Pending
- 2021-08-20 JP JP2023512003A patent/JP2023538582A/ja active Pending
- 2021-08-20 AU AU2021327616A patent/AU2021327616B2/en active Active
- 2021-08-20 CN CN202180050833.7A patent/CN115916345A/zh active Pending
- 2021-08-20 EP EP21858638.6A patent/EP4201405A1/en active Pending
- 2021-08-20 BR BR112023003144A patent/BR112023003144A2/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021327616B2 (en) | 2024-03-28 |
| JP2023538582A (ja) | 2023-09-08 |
| WO2022039551A1 (ko) | 2022-02-24 |
| EP4201405A1 (en) | 2023-06-28 |
| KR20220023187A (ko) | 2022-03-02 |
| US20230373994A1 (en) | 2023-11-23 |
| CN115916345A (zh) | 2023-04-04 |
| AU2021327616A1 (en) | 2023-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP22047876A (es) | Derivados de pirazolilo ?tiles como agentes anticancer?genos | |
| CL2020002695A1 (es) | Péptidos macrocíclicos contra actinetobacter baumannii | |
| MX2022010659A (es) | Compuestos altamente activos contra la enfermedad por coronavirus de 2019 (covid-19). | |
| CL2021001042A1 (es) | Nuevos compuestos antihelmínticos | |
| UY37201A (es) | Nuevos derivados de pirazolopirimidina | |
| PE20191650A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue | |
| BR112022004424A2 (pt) | Pró-fármacos antivirais e formulações dos mesmos | |
| ES2570401T3 (es) | Métodos de tratamiento usando dosis únicas de oritavancina | |
| AR062395A1 (es) | Uso de derivados del 2.5-dihidroxibenceno para el tratamiento de enfermedades oculares | |
| UY38816A (es) | Nuevos derivados de isoquinolina | |
| BR112022021748A2 (pt) | Compostos e composições para inibir a atividade de hif2a e seus métodos de uso | |
| BR112021011325A2 (pt) | Derivados de rapamicina | |
| BR112023015272A2 (pt) | Formulações farmacêuticas de centanafadina e métodos de fabricação e uso das mesmas | |
| CO2022011947A2 (es) | Compuestos tetracíclicos para el tratamiento de infecciones por vih | |
| BR112019018615A2 (pt) | compostos antimicrobianos, composições e usos dos mesmos | |
| PE20210123A1 (es) | Compuesto de anillo de metillactama y uso farmaceutico del mismo | |
| BR112023003144A2 (pt) | Derivado de pirrolopiridina e uso do mesmo | |
| CL2008001282A1 (es) | Composicion farmaceutica con actividad antimicrobiana que comprende un aminoacidos n halogenado y un agente antiinflamatorio; uso para prevenir o tratar una infeccion de tejidos, donde dicho tejido es ocular, nasal, seno nasal o dermico o una infeccion respiratoria. | |
| MX2019011220A (es) | Compuesto de pirrolopiridina novedoso, metodo de preparacion del mismo y uso del mismo. | |
| BR112023001924A2 (pt) | Derivados de benzimidazol, método de preparo para os mesmos e uso médico dos mesmos | |
| AR064152A1 (es) | Derivados de quinolina antibacterianos,composiciones farmaceuticas que los contienen y metodo de preparacion. | |
| BR112022010204A2 (pt) | Derivado do anel de piridina fusionado, método de preparação para o mesmo e uso farmacêutico do mesmo | |
| MX2023011297A (es) | Antagonista del dominio de alfa/beta hidrolasa 6 (abhd6). | |
| BR112022017779A2 (pt) | Imunomodulação de azaletos de o-het-arila | |
| BR112022014933A2 (pt) | Compostos e composições para uso no tratamento de distúrbios de pele |