BR112023002191A2 - Conjugados de fármaco de alvejamento de macrófago - Google Patents

Conjugados de fármaco de alvejamento de macrófago

Info

Publication number
BR112023002191A2
BR112023002191A2 BR112023002191A BR112023002191A BR112023002191A2 BR 112023002191 A2 BR112023002191 A2 BR 112023002191A2 BR 112023002191 A BR112023002191 A BR 112023002191A BR 112023002191 A BR112023002191 A BR 112023002191A BR 112023002191 A2 BR112023002191 A2 BR 112023002191A2
Authority
BR
Brazil
Prior art keywords
drug conjugates
targeting drug
macrophage targeting
chemical moiety
macrophage
Prior art date
Application number
BR112023002191A
Other languages
English (en)
Inventor
M Goldberg Alec
H Goldberg Samuel
I Goldberg James
Z Goldberg Isaiah
M Goldberg Michael
Original Assignee
P I F Entrepreneurs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by P I F Entrepreneurs Ltd filed Critical P I F Entrepreneurs Ltd
Publication of BR112023002191A2 publication Critical patent/BR112023002191A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

CONJUGADOS DE FÁRMACO DE ALVEJAMENTO DE MACRÓFAGO. São descritos no presente documento conjugados de fármaco de alvejamento de macrófago inovadores. Os conjugados de fármaco de alvejamento de macrófago compreendem uma porção química de fármaco, uma porção química de manose e um ligante que conecta a porção química de fármaco e a porção química de manose. O ligante pode compreender um grupo hidrazona ou um grupo oxima.
BR112023002191A 2020-08-10 2021-08-09 Conjugados de fármaco de alvejamento de macrófago BR112023002191A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063063486P 2020-08-10 2020-08-10
US202163158892P 2021-03-10 2021-03-10
PCT/IL2021/050968 WO2022034582A1 (en) 2020-08-10 2021-08-09 Macrophage targeting drug conjugates

Publications (1)

Publication Number Publication Date
BR112023002191A2 true BR112023002191A2 (pt) 2023-03-14

Family

ID=80247821

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023002191A BR112023002191A2 (pt) 2020-08-10 2021-08-09 Conjugados de fármaco de alvejamento de macrófago

Country Status (10)

Country Link
US (1) US20230355773A1 (pt)
EP (1) EP4192840A4 (pt)
JP (1) JP2023537128A (pt)
KR (1) KR20230049710A (pt)
CN (1) CN116096374A (pt)
AU (1) AU2021323520A1 (pt)
BR (1) BR112023002191A2 (pt)
CA (1) CA3187751A1 (pt)
IL (1) IL300482A (pt)
WO (1) WO2022034582A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2029599B1 (en) * 2021-11-02 2023-06-01 Univ Leiden Glycosylated Prodrugs
IL314497A (en) * 2022-01-25 2024-09-01 101 Therapeutics Ltd Compounds and methods for treating covid 2019

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT8922275A0 (it) * 1990-10-25 1989-11-06 Baldacci Lab Spa Nuovi derivati di corticosteroidi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
EP0721956B1 (en) * 1993-09-29 2000-08-02 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
WO1999047542A1 (fr) * 1998-03-19 1999-09-23 Nissin Food Products Co., Ltd. Medicaments contenant en tant que principe actif des composes steroides glycosyles substitues en position 21
GB0917054D0 (en) * 2009-09-29 2009-11-11 Cytoguide As Agents, uses and methods
KR20200108002A (ko) * 2018-01-08 2020-09-16 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 항체-접합체

Also Published As

Publication number Publication date
JP2023537128A (ja) 2023-08-30
EP4192840A1 (en) 2023-06-14
AU2021323520A1 (en) 2023-04-06
EP4192840A4 (en) 2024-03-13
IL300482A (en) 2023-04-01
CA3187751A1 (en) 2022-02-17
US20230355773A1 (en) 2023-11-09
WO2022034582A1 (en) 2022-02-17
KR20230049710A (ko) 2023-04-13
CN116096374A (zh) 2023-05-09

Similar Documents

Publication Publication Date Title
BR112023002191A2 (pt) Conjugados de fármaco de alvejamento de macrófago
MX2018010247A (es) Nuevos conjugados de amanitina.
NZ754811A (en) Pyrrolobenzodiazepine-antibody conjugates
BR112018069507A2 (pt) agentes de alta afinidade alvejados por antígeno de membrana específica da próstata para endoradioterapia de câncer de próstata
AU2018335378A1 (en) PSMA-targeting amanitin conjugates
WO2018091544A8 (en) SUBSTANCES FOR TARGETING VARIOUS SELECTED ORGANS OR TISSUES
WO2007105027A8 (en) Anticancer drugs conjugated to antibody via an enzyme cleavable linker
CR7171A (es) Composiciones farmaceuticas de farmacos y polimeros acidos neutralizados
UY31360A1 (es) Peptidos y polipeptidos permeabilizadores de celulas para celulas microbianas
EA201000994A2 (ru) Химически модифицированные малые молекулы
BR112023002417A2 (pt) Conjugado de anticorpo e fármaco
WO2020037009A8 (en) Conjugates and methods of using the same
MA43345A (fr) Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
WO2009042064A3 (en) Oligomer-nucleoside phosphate conjugates
MX2010005813A (es) Conjugados oligomero-triciclicos.
BR112022025061A2 (pt) Compostos que estabelecem como alvo brm e métodos de uso associados
ECSP20047171A (es) Composiciones de edb que se dirigen a il-12
BR112019005183A2 (pt) sistema paratransgênico inovador para o biocontrole de mosquitos transmissores de doença
UY38520A (es) Anticuerpos anti-pmel17, sus conjugados, composiciones que los comprenden, polinucleótidos, métodos y usos relacionados a los mismos
BR112023012377A2 (pt) Composições de trems modificadas e usos das mesmas
BR112022024691A2 (pt) Conjugados anticorpo biespecífico - fármaco direcionados a egfr e muc1 e usos dos mesmos
WO2007051004A3 (en) Conjugate vaccines for non-proteinaceous antigens
ES1290274Y (es) Sistema dispensador de hidrógeno.
MX2023005138A (es) Conjugados dirigidos que comprenden arnpi modificado.
WO2009032286A3 (en) Oligomer-calcium channel blocker conjugates