WO2007051004A3 - Conjugate vaccines for non-proteinaceous antigens - Google Patents

Conjugate vaccines for non-proteinaceous antigens Download PDF

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Publication number
WO2007051004A3
WO2007051004A3 PCT/US2006/042301 US2006042301W WO2007051004A3 WO 2007051004 A3 WO2007051004 A3 WO 2007051004A3 US 2006042301 W US2006042301 W US 2006042301W WO 2007051004 A3 WO2007051004 A3 WO 2007051004A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugate vaccines
proteinaceous antigens
antigens
proteinaceous
glycosphingolipid
Prior art date
Application number
PCT/US2006/042301
Other languages
French (fr)
Other versions
WO2007051004A2 (en
Inventor
Elizabeth Leadbetter
Michael B Brenner
Gurdyal Singh Besra
Original Assignee
Brigham & Womens Hospital
Univ Birmingham
Elizabeth Leadbetter
Michael B Brenner
Gurdyal Singh Besra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Univ Birmingham, Elizabeth Leadbetter, Michael B Brenner, Gurdyal Singh Besra filed Critical Brigham & Womens Hospital
Publication of WO2007051004A2 publication Critical patent/WO2007051004A2/en
Publication of WO2007051004A3 publication Critical patent/WO2007051004A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention is directed to pharmaceutical compositions that can be used to immunize subjects using, for example, lipid, glycan, or nucleic acid antigens. These antigens are conjugated to a glycosphingolipid.
PCT/US2006/042301 2005-10-28 2006-10-30 Conjugate vaccines for non-proteinaceous antigens WO2007051004A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73086205P 2005-10-28 2005-10-28
US60/730,862 2005-10-28

Publications (2)

Publication Number Publication Date
WO2007051004A2 WO2007051004A2 (en) 2007-05-03
WO2007051004A3 true WO2007051004A3 (en) 2007-06-14

Family

ID=37857718

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042301 WO2007051004A2 (en) 2005-10-28 2006-10-30 Conjugate vaccines for non-proteinaceous antigens

Country Status (1)

Country Link
WO (1) WO2007051004A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
JP5721620B2 (en) 2008-05-02 2015-05-20 キャンサー・リサーチ・テクノロジー・リミテッドＣａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｔｅｃｈｎｏｌｏｇｙ Ｌｉｍｉｔｅｄ Products and methods for stimulating an immune response
PT2827899E (en) * 2012-03-19 2015-11-18 Max Planck Ges Zur Förderung Der Wissenschaften E V Polysaccharide antigen-glycolipid conjugate vaccines
KR102235870B1 (en) 2012-12-06 2021-04-07 빅토리아 링크 엘티디 Conjugate compounds
EP2851092A1 (en) * 2013-09-18 2015-03-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein and peptide-free synthetic vaccines against streptococcus pneumoniae type 3
US11246918B2 (en) 2017-02-03 2022-02-15 Eva Barbara Schadeck Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003995A1 (en) * 1995-07-24 1997-02-06 Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
WO2006027685A2 (en) * 2004-09-07 2006-03-16 Novartis Vaccines And Diagnostics Srl Glycosylceramide adjuvant for saccharide antigens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003995A1 (en) * 1995-07-24 1997-02-06 Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
WO2006027685A2 (en) * 2004-09-07 2006-03-16 Novartis Vaccines And Diagnostics Srl Glycosylceramide adjuvant for saccharide antigens

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DESHPANDE P P ET AL: "STRATEGY IN OLIGOSACCHARIDE SYNTHESIS: AN APPLICATION TO A CONCISE TOTAL SYNTHESIS OF THE KH-1(ADENOCARCINOMA) ANTIGEN", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 120, no. 7, 2 April 1998 (1998-04-02), pages 1600 - 1614, XP001118243, ISSN: 0002-7863 *
DESHPANDE P P ET AL: "TOTAL SYNTHESIS OF THE POTENTIAL ANTICANCER VACCINE KH-1 ADENOCARCINOMA ANTIGEN", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 387, no. 6629, 8 May 1997 (1997-05-08), pages 164 - 166, XP001118245, ISSN: 0028-0836 *
IIJIMA H ET AL: "Structure-activity relationship and conformational analysis of monoglycosylceramides on the syngeneic mixed leukocyte reaction", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 6, no. 10, October 1998 (1998-10-01), pages 1905 - 1910, XP002270443, ISSN: 0968-0896 *
PARK ET AL: "Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 118, 1996, pages 11488 - 11500, XP002155265, ISSN: 0002-7863 *
RAGUPATHI ET AL: "Immunization of mice with a fully synthetic globo H antigen results in antibodies against human cancer cells: a combined chemical-immunological approach to the fashioning of an anticancer vaccine", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, WILEY VCH VERLAG, WEINHEIM, DE, vol. 36, no. 1-2, 1997, pages 125 - 128, XP002155263, ISSN: 1433-7851 *
RICH J R ET AL: "S-linked ganglioside analogues for use in conjugate vaccines", ORGANIC LETTERS, vol. 6, no. 6, 2004, pages 897 - 900, XP002426124 *

Also Published As

Publication number Publication date
WO2007051004A2 (en) 2007-05-03

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