BR112023000338A2 - Composição farmacêutica compreendendo um derivado de diaminopirimidina ou sal farmaceuticamente aceitável do mesmo e processos para preparar a mesma - Google Patents

Composição farmacêutica compreendendo um derivado de diaminopirimidina ou sal farmaceuticamente aceitável do mesmo e processos para preparar a mesma

Info

Publication number
BR112023000338A2
BR112023000338A2 BR112023000338A BR112023000338A BR112023000338A2 BR 112023000338 A2 BR112023000338 A2 BR 112023000338A2 BR 112023000338 A BR112023000338 A BR 112023000338A BR 112023000338 A BR112023000338 A BR 112023000338A BR 112023000338 A2 BR112023000338 A2 BR 112023000338A2
Authority
BR
Brazil
Prior art keywords
preparing
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
same
Prior art date
Application number
BR112023000338A
Other languages
English (en)
Inventor
Park Dong-Min
Kim Su-Hyeon
Cheon Eun-Pa
Ha Tae-Lin
Yang Jun-Mo
Park Yoong-Sik
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of BR112023000338A2 publication Critical patent/BR112023000338A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO UM DERIVADO DE DIAMINOPIRIMIDINA OU SAL FARMACEUTICAMENTE ACEITÁVEL DO MESMO E PROCESSOS PARA PREPARAR A MESMA. A presente invenção fornece uma composição farmacêutica compreendendo (S)-N-(1-(2-((4-amino-3-nitrofenil)amino)-6-propilpirimidin-4-il)pirrolidin-3-il)acetamida ou um sal farmaceuticamente aceitável do mesmo que possui uma atividade como um agonista do receptor 5-HT4 e um agente acidificante; e um processo para preparar a mesma.
BR112023000338A 2020-07-09 2021-07-01 Composição farmacêutica compreendendo um derivado de diaminopirimidina ou sal farmaceuticamente aceitável do mesmo e processos para preparar a mesma BR112023000338A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020200084595A KR20220006776A (ko) 2020-07-09 2020-07-09 다이아미노피리미딘 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 약학 조성물 및 이의 제조방법
PCT/KR2021/008327 WO2022010175A1 (en) 2020-07-09 2021-07-01 Pharmaceutical compositions comprising a diaminopyrimidine derivative or pharmaceutically acceptable salt thereof and processes for preparing the same

Publications (1)

Publication Number Publication Date
BR112023000338A2 true BR112023000338A2 (pt) 2023-03-28

Family

ID=79552635

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023000338A BR112023000338A2 (pt) 2020-07-09 2021-07-01 Composição farmacêutica compreendendo um derivado de diaminopirimidina ou sal farmaceuticamente aceitável do mesmo e processos para preparar a mesma

Country Status (10)

Country Link
US (1) US20230255967A1 (pt)
EP (1) EP4178550A4 (pt)
JP (1) JP2023534186A (pt)
KR (1) KR20220006776A (pt)
CN (1) CN116133649A (pt)
AU (1) AU2021305561A1 (pt)
BR (1) BR112023000338A2 (pt)
CA (1) CA3185116A1 (pt)
MX (1) MX2023000364A (pt)
WO (1) WO2022010175A1 (pt)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130035344A1 (en) * 2009-12-29 2013-02-07 Kowa Co., Ltd. Pharmaceutical composition for oral administration
WO2012115478A2 (en) * 2011-02-25 2012-08-30 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
WO2013114389A1 (en) * 2011-12-21 2013-08-08 Mylan Laboratories Limited. Process for preparing solid oral formulations comprising low dose of entecavir
KR101832842B1 (ko) * 2012-01-13 2018-02-27 한미약품 주식회사 안정성이 향상된 에페리손 또는 이의 약학적으로 허용 가능한 염 및 특정 산성화제를 포함하는 약학 조성물
AU2015246500B2 (en) * 2014-04-14 2018-03-22 National Institute Of Biological Sciences, Beijing 5-HT2B Antagonists
KR102293907B1 (ko) * 2015-06-30 2021-08-26 한미약품 주식회사 이리노테칸 함유 경구용 고형제제 및 그 제조방법
CN107216319B (zh) * 2016-03-21 2021-10-08 中国科学院上海药物研究所 一种2，4-二氨基嘧啶类衍生物、其制备方法及用途
DK3586832T3 (da) * 2018-06-28 2021-04-06 Synformulas Gmbh Farmaceutisk sammensætning til behandlingen af forstoppelse

Also Published As

Publication number Publication date
US20230255967A1 (en) 2023-08-17
WO2022010175A1 (en) 2022-01-13
EP4178550A4 (en) 2024-09-11
MX2023000364A (es) 2023-02-27
EP4178550A1 (en) 2023-05-17
CA3185116A1 (en) 2022-01-13
KR20220006776A (ko) 2022-01-18
CN116133649A (zh) 2023-05-16
JP2023534186A (ja) 2023-08-08
AU2021305561A1 (en) 2023-02-09

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