BR112023000142A2 - Derivados de benzodiazepina úteis no tratamento de infecção pelo vírus sincicial respiratório - Google Patents

Derivados de benzodiazepina úteis no tratamento de infecção pelo vírus sincicial respiratório

Info

Publication number
BR112023000142A2
BR112023000142A2 BR112023000142A BR112023000142A BR112023000142A2 BR 112023000142 A2 BR112023000142 A2 BR 112023000142A2 BR 112023000142 A BR112023000142 A BR 112023000142A BR 112023000142 A BR112023000142 A BR 112023000142A BR 112023000142 A2 BR112023000142 A2 BR 112023000142A2
Authority
BR
Brazil
Prior art keywords
respiratory syncytial
syncytial virus
treatment
derivatives useful
virus infection
Prior art date
Application number
BR112023000142A
Other languages
English (en)
Inventor
Barrett Matthew
Stuart Cockerill George
Good James
Alex Avery Craig
James Cochrane Edward
Paul Jones Stefan
Thomas Onions Stuart
Joseph Warner Andrew
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR112023000142A2 publication Critical patent/BR112023000142A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

DERIVADOS DE BENZODIAZEPINA ÚTEIS NOTRATAMENTO DE INFECÇÃO PELO VÍRUS SINCICIAL RESPIRATÓRIO. São descritos compostos derivados de benzodiazepina e sais farmaceuticamente aceitáveis dos mesmos, além de composições e produtos compreendendo os mesmos, e seus usos no tratamento ou prevenção de uma infecção pelo vírus sincicial respiratório (VSR).
BR112023000142A 2020-07-07 2021-07-07 Derivados de benzodiazepina úteis no tratamento de infecção pelo vírus sincicial respiratório BR112023000142A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2010409.7A GB202010409D0 (en) 2020-07-07 2020-07-07 Pharmaceutical compounds
PCT/GB2021/051731 WO2022008911A1 (en) 2020-07-07 2021-07-07 Benzodiazepine derivatives useful in treating a respiratory syncytial virus infection

Publications (1)

Publication Number Publication Date
BR112023000142A2 true BR112023000142A2 (pt) 2023-01-31

Family

ID=72050502

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023000142A BR112023000142A2 (pt) 2020-07-07 2021-07-07 Derivados de benzodiazepina úteis no tratamento de infecção pelo vírus sincicial respiratório

Country Status (10)

Country Link
US (1) US20230270751A1 (pt)
EP (1) EP4178964A1 (pt)
JP (1) JP2023539985A (pt)
KR (1) KR20230035597A (pt)
CN (1) CN116075516A (pt)
BR (1) BR112023000142A2 (pt)
CA (1) CA3188752A1 (pt)
GB (1) GB202010409D0 (pt)
MX (1) MX2023000440A (pt)
WO (1) WO2022008911A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201911944D0 (en) 2019-08-20 2019-10-02 Reviral Ltd Pharmaceutical compounds
GB202102602D0 (en) 2021-02-24 2021-04-07 Reviral Ltd Pharmaceutical compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101125899B1 (ko) 2002-09-20 2012-04-12 애로우 쎄라퓨틱스 리미티드 벤조디아제핀 유도체 및 이를 함유하는 약학 조성물
US20070293482A1 (en) 2004-03-19 2007-12-20 Novartis Pharmaceuticals Corporation Process for Preparing Benzodiazepines
GB0406280D0 (en) 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Chemical compounds
GB201506448D0 (en) 2015-04-16 2015-06-03 Univ Durham An antimicrobial compound
RU2738232C2 (ru) 2015-07-22 2020-12-09 Энанта Фармасьютикалс, Инк. Производные бензодиазепина как ингибиторы rsv
GB201613942D0 (en) 2016-08-15 2016-09-28 Univ Of Durham The An antimicrobial compound
WO2018129287A1 (en) 2017-01-06 2018-07-12 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as rsv inhibitors
US10752598B2 (en) 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
GB201911944D0 (en) 2019-08-20 2019-10-02 Reviral Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
US20230270751A1 (en) 2023-08-31
GB202010409D0 (en) 2020-08-19
KR20230035597A (ko) 2023-03-14
CA3188752A1 (en) 2022-01-13
WO2022008911A1 (en) 2022-01-13
EP4178964A1 (en) 2023-05-17
CN116075516A (zh) 2023-05-05
JP2023539985A (ja) 2023-09-21
MX2023000440A (es) 2023-04-13

Similar Documents

Publication Publication Date Title
NO2020026I1 (no) Raltegravir eller et farmasøytisk akseptabelt salt derav, spesielt kaliumsaltet
ZA202107015B (en) Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
BRPI0414330A (pt) composto, processo para preparação do mesmo, métodos para produção de um efeito antibacteriano, para inibição de dna girase bacteriana, e para tratamento de uma infecção bacteriana em um animal de sangue quente, uso de um composto, e, composição farmacêutica
BR112023000142A2 (pt) Derivados de benzodiazepina úteis no tratamento de infecção pelo vírus sincicial respiratório
BR0208811A (pt) Derivados de pirazol para tratamento de hiv
ATE355064T1 (de) Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
ES2051641B1 (es) Procedimientos para la preparacion de compuestos derivados de tiourea.
TR200500745T2 (tr) Damar gelişimi inhibitörleri olarak kuinazolin türevleri.
EA202190854A1 (ru) Ингибиторы репликации вируса иммунодефицита человека
BR112021025655A2 (pt) Inibidores da replicação do vírus da imunodeficiência humana
PH12021550632A1 (en) Monomer and multimeric anti-hbv agents
WO2015160907A3 (en) Potent and selective inhibitors of hepatitis c virus
BR9912142A (pt) 6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as
EA202092439A1 (ru) Гетероароматические соединения, обладающие активностью против rsv
MX2022009871A (es) Compuestos tetraciclicos para tratar la infeccion por el virus de la inmunodeficiencia humana (vih).
EA202193223A1 (ru) Другие гетероароматические соединения, действующие против рсв
EA202191482A1 (ru) Другие гетероароматические соединения, обладающие активностью против rsv
EA202091835A1 (ru) Замещенные циклоалкилом пиразолопиримидины, обладающие активностью против rsv
MX2023008137A (es) Compuestos de piridotriazina sustituidos y usos de estos.
ATE554764T1 (de) Wirkungsvolle vereinfachte derivate von immunosuppressiva
EA202290157A1 (ru) Производные третичных аминов и их применение для лечения вирусной инфекции
NO965591L (no) Kombinasjonsbehandling av HIV-infeksjon
BR112018002681A2 (pt) ?composto, composição, e, método para tratamento de infecção por hiv?
EA202192268A1 (ru) Мостиковые трициклические карбамоилпиридоновые соединения и их фармацевтическое применение
ES2190456T3 (es) Combinacion de inhibidores de la proteasa del vih.