BR112022022574A2 - Composição medicinal chinesa tradicional para o tratamento de pneumonia por coronavírus, método de preparação, método de detecção e uso da mesma - Google Patents

Composição medicinal chinesa tradicional para o tratamento de pneumonia por coronavírus, método de preparação, método de detecção e uso da mesma

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Publication number
BR112022022574A2
BR112022022574A2 BR112022022574A BR112022022574A BR112022022574A2 BR 112022022574 A2 BR112022022574 A2 BR 112022022574A2 BR 112022022574 A BR112022022574 A BR 112022022574A BR 112022022574 A BR112022022574 A BR 112022022574A BR 112022022574 A2 BR112022022574 A2 BR 112022022574A2
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parts
traditional chinese
chinese medicinal
medicinal composition
preparation
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BR112022022574A
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English (en)
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Lin Deliang
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Beijing Handian Pharmaceutical Co Ltd
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Publication of BR112022022574A2 publication Critical patent/BR112022022574A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/882—Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/95—Detectors specially adapted therefor; Signal analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Medicines Containing Plant Substances (AREA)
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Abstract

COMPOSIÇÃO MEDICINAL CHINESA TRADICIONAL PARA O TRATAMENTO DE PNEUMONIA POR CORONAVÍRUS, MÉTODO DE PREPARAÇÃO, MÉTODO DE DETECÇÃO E USO DA MESMA. A presente invenção refere-se a uma composição medicinal Chinesa tradicional para o tratamento de pneumonia por coronavírus, um método de preparação, um método de detecção e uso da mesma. A composição medicinal Chinesa tradicional é preparada principalmente a partir das seguintes matérias-primas em partes em peso: 250-400 partes de Citri reticulatae pericarpium, 100-200 partes de Atractylodis rhizoma, 100-200 partes de Magnoliae officinalis cortex, 200-300 partes de Glycyrrhizae radix et rhizoma, 200-300 partes de Agastache rugosus, 200-300 partes de Acori tatarinowii rhizoma, 250-330 partes de Jujubae fructus e 100-200 partes de Zingiberis rhizoma recens. Além disso, são fornecidos na presente invenção um método de preparação e um método de detecção para a composição medicinal Chinesa tradicional. O método de preparação fornecido na presente invenção melhora o teor e a taxa de transferência de hesperidina na composição medicinal Chinesa tradicional. Por meio da proporção das matérias-primas, a composição medicinal Chinesa tradicional fornecida na presente invenção tem poucos efeitos colaterais e pode ser usada para tratar doenças de tipo cold-dampness (pelo frio-umidade) e, em particular, tem um efeito muito bom no tratamento de pneumonia pelo coronavírus.
BR112022022574A 2020-05-08 2020-11-13 Composição medicinal chinesa tradicional para o tratamento de pneumonia por coronavírus, método de preparação, método de detecção e uso da mesma BR112022022574A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010384148.5A CN111407877A (zh) 2020-05-08 2020-05-08 治疗新型冠状病毒肺炎的中药组合物、制备方法、检测方法及其用途
PCT/CN2020/128753 WO2021223397A1 (zh) 2020-05-08 2020-11-13 治疗新型冠状病毒肺炎的中药组合物、制备方法、检测方法及其用途

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US (1) US20230181666A1 (pt)
EP (1) EP4147708A4 (pt)
JP (1) JP2023525739A (pt)
KR (1) KR20230009449A (pt)
CN (2) CN111407877A (pt)
BR (1) BR112022022574A2 (pt)
WO (1) WO2021223397A1 (pt)

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CN111407877A (zh) * 2020-05-08 2020-07-14 北京汉典制药有限公司 治疗新型冠状病毒肺炎的中药组合物、制备方法、检测方法及其用途
CN111983106B (zh) * 2020-08-19 2021-06-22 广东一方制药有限公司 化湿败毒组合物的质量控制方法
CN112067738A (zh) * 2020-08-19 2020-12-11 广东一方制药有限公司 化湿败毒组合物的鉴别方法
CN112043804A (zh) * 2020-08-19 2020-12-08 广东一方制药有限公司 化湿败毒颗粒及其制备方法和抗病毒药物
CN111735896B (zh) * 2020-08-19 2020-11-27 广东一方制药有限公司 化湿败毒组合物特征图谱的构建方法
CN113281433B (zh) * 2021-05-19 2022-10-21 一力制药(罗定)有限公司 一种治疗胃肠型感冒的中药组合物制剂的含量测定方法
CN113499384B (zh) * 2021-06-16 2022-07-29 首都医科大学附属北京中医医院 一种中药组合物和药物制剂及其制备方法和在抗冠状病毒中的应用
CN113624904B (zh) * 2021-09-01 2023-05-23 广东一方制药有限公司 姜竹茹中药配方颗粒中生姜的鉴别方法
CN113768984A (zh) * 2021-09-13 2021-12-10 澳门科技大学 一种中药组合物及其制备方法和应用
CN114588134B (zh) * 2022-03-04 2023-04-11 湖南润农生态茶油有限公司 一种用于预防和辅助治疗呼吸道疾病的中药组合物雾化液和应用
CN115097058B (zh) * 2022-06-24 2023-08-04 广西新桂环保科技集团有限公司 南酸枣的薄层色谱鉴别方法
CN115814049B (zh) * 2022-12-12 2024-05-07 北京博奥晶方生物科技有限公司 中药组合物及其制备方法和应用
CN115792041B (zh) * 2022-12-28 2023-07-25 中山市中智药业集团有限公司 一种同时测定陈皮挥发性成分含量的方法及其应用

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CN1456292A (zh) * 2003-04-10 2003-11-19 毛友昌 平胃颗粒及制备方法
CN100339101C (zh) * 2003-07-07 2007-09-26 天津天士力制药股份有限公司 藿香正气滴丸的制备方法及其用途
CN100518783C (zh) * 2006-02-13 2009-07-29 浙江大德药业集团有限公司 藿香正气口腔崩解片的检测方法
CN101947304A (zh) * 2010-08-02 2011-01-19 李晓明 一种治疗虚寒性胃肠病的中药组合物
CN104523929B (zh) * 2014-12-23 2018-05-29 湖南省中医药研究院 一种治疗感冒的中药组合物及其制备方法与应用
CN111407877A (zh) * 2020-05-08 2020-07-14 北京汉典制药有限公司 治疗新型冠状病毒肺炎的中药组合物、制备方法、检测方法及其用途

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EP4147708A1 (en) 2023-03-15
CN112274620A (zh) 2021-01-29
CN112274620B (zh) 2023-03-17
EP4147708A4 (en) 2023-10-25
WO2021223397A1 (zh) 2021-11-11
US20230181666A1 (en) 2023-06-15
JP2023525739A (ja) 2023-06-19
CN111407877A (zh) 2020-07-14

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