BR112022021525A2 - Derivados de pirrolo [2,3-d] pirimidina - Google Patents

Derivados de pirrolo [2,3-d] pirimidina

Info

Publication number
BR112022021525A2
BR112022021525A2 BR112022021525A BR112022021525A BR112022021525A2 BR 112022021525 A2 BR112022021525 A2 BR 112022021525A2 BR 112022021525 A BR112022021525 A BR 112022021525A BR 112022021525 A BR112022021525 A BR 112022021525A BR 112022021525 A2 BR112022021525 A2 BR 112022021525A2
Authority
BR
Brazil
Prior art keywords
pyrimidine derivatives
pyrole
jak
pyrrolo
inhibitors
Prior art date
Application number
BR112022021525A
Other languages
English (en)
Inventor
Eugene Dowty Martin
Kumar Malhotra Bimal
Jordan Samardjiev Ivan
Matthew Samas Brian
Walter Strohbach Joseph
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR112022021525A2 publication Critical patent/BR112022021525A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

A presente invenção refere-se a derivados de pirrolo {2,3-d} pirimidina, seu uso como inibidores de Janus Quinase (JAK), e composições farmacêuticas contendo os mesmos.
BR112022021525A 2020-05-28 2021-05-25 Derivados de pirrolo [2,3-d] pirimidina BR112022021525A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062704796P 2020-05-28 2020-05-28
US202063037366P 2020-06-10 2020-06-10
PCT/IB2021/054516 WO2021240356A1 (en) 2020-05-28 2021-05-25 Pyrrolo[2,3-d]pyrimidine derivatives

Publications (1)

Publication Number Publication Date
BR112022021525A2 true BR112022021525A2 (pt) 2022-12-13

Family

ID=76197508

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022021525A BR112022021525A2 (pt) 2020-05-28 2021-05-25 Derivados de pirrolo [2,3-d] pirimidina

Country Status (12)

Country Link
US (1) US20230219963A1 (pt)
EP (1) EP4157845A1 (pt)
JP (1) JP2021187848A (pt)
KR (1) KR20230015989A (pt)
CN (1) CN115667263A (pt)
AU (1) AU2021281643B2 (pt)
BR (1) BR112022021525A2 (pt)
CA (1) CA3184647A1 (pt)
IL (1) IL298450A (pt)
MX (1) MX2022014940A (pt)
TW (1) TW202204361A (pt)
WO (1) WO2021240356A1 (pt)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2958921T3 (da) * 2013-02-22 2017-11-06 Pfizer Pyrrolo[2,3-D]pyrimidin-derivater som hæmmere af Janus kinaser (JAK)
EP3180344B1 (en) * 2014-08-12 2019-09-18 Pfizer Inc Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase

Also Published As

Publication number Publication date
KR20230015989A (ko) 2023-01-31
CA3184647A1 (en) 2021-12-02
JP2021187848A (ja) 2021-12-13
IL298450A (en) 2023-01-01
EP4157845A1 (en) 2023-04-05
CN115667263A (zh) 2023-01-31
AU2021281643A1 (en) 2022-11-24
TW202204361A (zh) 2022-02-01
AU2021281643B2 (en) 2024-02-15
WO2021240356A1 (en) 2021-12-02
MX2022014940A (es) 2023-01-04
US20230219963A1 (en) 2023-07-13

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: PFIZER INC. (US)