BR112022020776A2 - Pirrolo[1,2-d][1,2,4]triazina-2-il-acetamidas como inibidores da via do inflamassoma de nlrp3 - Google Patents
Pirrolo[1,2-d][1,2,4]triazina-2-il-acetamidas como inibidores da via do inflamassoma de nlrp3Info
- Publication number
- BR112022020776A2 BR112022020776A2 BR112022020776A BR112022020776A BR112022020776A2 BR 112022020776 A2 BR112022020776 A2 BR 112022020776A2 BR 112022020776 A BR112022020776 A BR 112022020776A BR 112022020776 A BR112022020776 A BR 112022020776A BR 112022020776 A2 BR112022020776 A2 BR 112022020776A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- pyrolo
- triazine
- pathway
- acetamides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
PIRROLO[1,2-D][1,2,4]TRIAZINA-2-ILACETAMIDAS COMO INIBIDORES DA VIA DO INFLAMASSOMA DE NLRP3. A presente invenção refere-se a compostos para uso como inibidores da produção de inflamassoma de NLRP3, em que tais compostos são conforme definidos pelos compostos da fórmula (I) e em que os números inteiros R1, R2 e R3 são definidos na descrição, e em que os compostos podem ser úteis como medicamentos, por exemplo, para uso no tratamento de uma doença ou transtorno que é associado à atividade de inflamassoma de NLRP3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20382298 | 2020-04-15 | ||
PCT/EP2021/059755 WO2021209539A1 (en) | 2020-04-15 | 2021-04-15 | Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acetamides as inhibitors of the nlrp3 inflammasome pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022020776A2 true BR112022020776A2 (pt) | 2022-11-29 |
Family
ID=70391033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022020776A BR112022020776A2 (pt) | 2020-04-15 | 2021-04-15 | Pirrolo[1,2-d][1,2,4]triazina-2-il-acetamidas como inibidores da via do inflamassoma de nlrp3 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230183248A1 (pt) |
EP (1) | EP4135842A1 (pt) |
JP (1) | JP2023521242A (pt) |
KR (1) | KR20230002652A (pt) |
CN (1) | CN115485026A (pt) |
AU (1) | AU2021255895A1 (pt) |
BR (1) | BR112022020776A2 (pt) |
CA (1) | CA3174829A1 (pt) |
MX (1) | MX2022012896A (pt) |
WO (1) | WO2021209539A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114478537B (zh) * | 2020-11-13 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 环酰胺并环化合物及其医药用途 |
WO2023118521A1 (en) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
WO2024013395A1 (en) | 2022-07-14 | 2024-01-18 | Ac Immune Sa | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
WO2024023266A1 (en) | 2022-07-28 | 2024-02-01 | Ac Immune Sa | Novel compounds |
WO2024064655A1 (en) * | 2022-09-20 | 2024-03-28 | BioAge Labs, Inc. | Indazole and pyrazolopyridine compounds as inhibitors of nlrp3 inflammasome |
WO2024064245A1 (en) | 2022-09-23 | 2024-03-28 | Merck Sharp & Dohme Llc | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
CN116023296B (zh) * | 2022-12-29 | 2023-07-07 | 上海国创医药股份有限公司 | 一种马来酸氟伏沙明的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7157804B2 (ja) | 2017-10-17 | 2022-10-20 | ノバルティス アーゲー | Nlrp活性に関連する病態を治療するためのスルホンアミド及びその組成物 |
GB201721185D0 (en) | 2017-12-18 | 2018-01-31 | Nodthera Ltd | Sulphonyl urea derivatives |
GB201803393D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
WO2020010143A1 (en) | 2018-07-03 | 2020-01-09 | Novartis Inflammasome Research, Inc. | Nlrp modulators |
CA3105521A1 (en) | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Sulfonimidamide compounds as inhibitors of interleukin-1 activity |
US20210308140A1 (en) | 2018-07-25 | 2021-10-07 | Novartis Ag | Nlrp3 inflammasome inhibitors |
WO2020037116A1 (en) | 2018-08-17 | 2020-02-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Small molecule pyrin-domain targeted nlrp3 inflammasome inhibitors |
-
2021
- 2021-04-15 JP JP2022562733A patent/JP2023521242A/ja active Pending
- 2021-04-15 EP EP21717912.6A patent/EP4135842A1/en active Pending
- 2021-04-15 KR KR1020227039475A patent/KR20230002652A/ko active Search and Examination
- 2021-04-15 WO PCT/EP2021/059755 patent/WO2021209539A1/en unknown
- 2021-04-15 BR BR112022020776A patent/BR112022020776A2/pt unknown
- 2021-04-15 CN CN202180028892.4A patent/CN115485026A/zh active Pending
- 2021-04-15 AU AU2021255895A patent/AU2021255895A1/en active Pending
- 2021-04-15 US US17/996,023 patent/US20230183248A1/en active Pending
- 2021-04-15 MX MX2022012896A patent/MX2022012896A/es unknown
- 2021-04-15 CA CA3174829A patent/CA3174829A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3174829A1 (en) | 2021-10-21 |
CN115485026A (zh) | 2022-12-16 |
EP4135842A1 (en) | 2023-02-22 |
JP2023521242A (ja) | 2023-05-23 |
US20230183248A1 (en) | 2023-06-15 |
KR20230002652A (ko) | 2023-01-05 |
MX2022012896A (es) | 2022-11-09 |
WO2021209539A1 (en) | 2021-10-21 |
AU2021255895A1 (en) | 2022-12-15 |
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