BR112022020468A2 - Processo para sintetizar compostos de triarilmetano sulfonado - Google Patents

Processo para sintetizar compostos de triarilmetano sulfonado

Info

Publication number
BR112022020468A2
BR112022020468A2 BR112022020468A BR112022020468A BR112022020468A2 BR 112022020468 A2 BR112022020468 A2 BR 112022020468A2 BR 112022020468 A BR112022020468 A BR 112022020468A BR 112022020468 A BR112022020468 A BR 112022020468A BR 112022020468 A2 BR112022020468 A2 BR 112022020468A2
Authority
BR
Brazil
Prior art keywords
chem
formula
synthesizing
sulphonated
triphenylmethane
Prior art date
Application number
BR112022020468A
Other languages
English (en)
Inventor
Queru Stéphane
Sayah Babak
Drillaud Nicolas
Lopez Nicolas
Original Assignee
Provepharm Life Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provepharm Life Solutions filed Critical Provepharm Life Solutions
Publication of BR112022020468A2 publication Critical patent/BR112022020468A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
    • C07C303/06—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with sulfuric acid or sulfur trioxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/49—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0025—Crystal modifications; Special X-ray patterns
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
    • C09B67/0092—Dyes in solid form
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0096—Purification; Precipitation; Filtration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESSO PARA SINTETIZAR COMPOSTOS DE TRIARILMETANO SULFONADO. É descrito um processo para sintetizar um composto correspondente à fórmula [Chem I] este processo compreendendo pelo menos as seguintes etapas: a) condensar o composto benzaldeído da fórmula [Chem II] com a dialquilanilina da fórmula [Chem III] para dar o trifenilmetano da fórmula [Chem IV], b) tratar o trifenilmetano da fórmula [Chem IV] com ácido sulfúrico para formar a trifenilmetano sulfonado da fórmula [Chem V], c) oxidar o trifenilmetano sulfonado de fórmula [Chem V] com uma quinona. Também é descrito o uso deste processo para a preparação de azul patente.
BR112022020468A 2020-04-10 2021-04-01 Processo para sintetizar compostos de triarilmetano sulfonado BR112022020468A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2003638A FR3109151B1 (fr) 2020-04-10 2020-04-10 Procédé de synthèse de composés triarylméthane sulfonés
PCT/EP2021/058771 WO2021204711A1 (fr) 2020-04-10 2021-04-01 Procédé de synthèse de composés triarylméthane sulfonés

Publications (1)

Publication Number Publication Date
BR112022020468A2 true BR112022020468A2 (pt) 2022-11-29

Family

ID=70804843

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022020468A BR112022020468A2 (pt) 2020-04-10 2021-04-01 Processo para sintetizar compostos de triarilmetano sulfonado

Country Status (8)

Country Link
US (1) US20230348372A1 (pt)
EP (1) EP4132905B1 (pt)
CN (1) CN115485264A (pt)
BR (1) BR112022020468A2 (pt)
FR (1) FR3109151B1 (pt)
IL (1) IL297180A (pt)
MX (1) MX2022012619A (pt)
WO (1) WO2021204711A1 (pt)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE46384C (de) farbwerke, vorm. meister, lucius & brüning in Höchst a. M Verfahren zur Darstellung grüner und blaugrüner Farbstoffe aus der Malachitgrün-Reihe
US1531507A (en) 1922-07-24 1925-03-31 Nat Aniline & Chem Co Inc Manufacture of benzaldehyde-2.5-disulfonic acil
US7534911B2 (en) 2005-04-04 2009-05-19 Innovassynth Technologies (India) Ltd. Process for the preparation of Isosulphan Blue
US20080281127A1 (en) 2007-05-11 2008-11-13 Apicore, Llc Process for preparation of isosulfan blue
WO2017118882A1 (en) 2016-01-09 2017-07-13 Dishman Pharmaceuticals And Chemicals Ltd. An improved process for the preparation of isosulfan blue
WO2017218764A1 (en) 2016-06-16 2017-12-21 Beloteca, Inc. Method for preparation of isosulfan blue
WO2018008040A1 (en) 2016-07-06 2018-01-11 Biophore India Pharmaceuticals Pvt. Ltd. Isosulfan blue, its crystalline form and process for preparation thereof
RU2654862C1 (ru) * 2017-10-24 2018-05-23 Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") Способ очистки дисульфопроизводного диаминотрифенилметанового красителя

Also Published As

Publication number Publication date
CN115485264A (zh) 2022-12-16
US20230348372A1 (en) 2023-11-02
EP4132905A1 (fr) 2023-02-15
MX2022012619A (es) 2022-11-07
FR3109151B1 (fr) 2022-04-08
FR3109151A1 (fr) 2021-10-15
WO2021204711A1 (fr) 2021-10-14
IL297180A (en) 2022-12-01
EP4132905B1 (fr) 2024-05-15

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