BR112022020072A2 - Genes cd163, células, linhagens de células, par de grnas, complexo crispr, métodos para editar um gene cd163, preparar uma célula, produzir animais e determinar a presença ou ausência de uma sequência editada, embrião, leitão ou porco adulto, iniciador de pcr, sonda de pcr, usos e método de criação de um porco resistente ao prrsv - Google Patents

Genes cd163, células, linhagens de células, par de grnas, complexo crispr, métodos para editar um gene cd163, preparar uma célula, produzir animais e determinar a presença ou ausência de uma sequência editada, embrião, leitão ou porco adulto, iniciador de pcr, sonda de pcr, usos e método de criação de um porco resistente ao prrsv

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Publication number
BR112022020072A2
BR112022020072A2 BR112022020072A BR112022020072A BR112022020072A2 BR 112022020072 A2 BR112022020072 A2 BR 112022020072A2 BR 112022020072 A BR112022020072 A BR 112022020072A BR 112022020072 A BR112022020072 A BR 112022020072A BR 112022020072 A2 BR112022020072 A2 BR 112022020072A2
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Brazil
Prior art keywords
gene
edit
prrsv
cell
pig
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BR112022020072A
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English (en)
Portuguese (pt)
Inventor
Mark Cigan Andrew
Edward Lightner Jonathan
Scott Culbertson Matthew
Thomas Christianson William
Beaton Benjamin
Burger Brian
Barnes Dylan
Campbell Matthew
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Genus Plc
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Publication of BR112022020072A2 publication Critical patent/BR112022020072A2/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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BR112022020072A 2020-05-05 2021-05-04 Genes cd163, células, linhagens de células, par de grnas, complexo crispr, métodos para editar um gene cd163, preparar uma célula, produzir animais e determinar a presença ou ausência de uma sequência editada, embrião, leitão ou porco adulto, iniciador de pcr, sonda de pcr, usos e método de criação de um porco resistente ao prrsv BR112022020072A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063020128P 2020-05-05 2020-05-05
US202063021370P 2020-05-07 2020-05-07
PCT/GB2021/051060 WO2021224599A1 (en) 2020-05-05 2021-05-04 Methods for improving the health of porcine species by targeted inactivation of cd163

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BR112022020072A2 true BR112022020072A2 (pt) 2022-11-29

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Country Status (10)

Country Link
US (5) US11208659B2 (https=)
EP (1) EP4145991A1 (https=)
JP (1) JP2023525263A (https=)
KR (1) KR20230006827A (https=)
CN (5) CN118773199A (https=)
AU (1) AU2021268263A1 (https=)
BR (1) BR112022020072A2 (https=)
CA (1) CA3179710A1 (https=)
MX (1) MX2022013704A (https=)
WO (1) WO2021224599A1 (https=)

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CA3179710A1 (en) * 2020-05-05 2021-11-11 Andrew Mark CIGAN Methods for improving the health of porcine species by targeted inactivation of cd163
US20250064032A1 (en) 2021-12-10 2025-02-27 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2024097603A2 (en) * 2022-11-02 2024-05-10 Abs Global, Inc. Method of creating gene edited animals comprising a wild type allele

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CN108753832A (zh) * 2018-04-20 2018-11-06 中山大学 一种利用CRISPR/Cas9编辑大白猪CD163基因的方法
CN109055385B (zh) * 2018-08-21 2021-08-27 吉林大学 一种有效抑制ⅱ型prrsv感染的基因序列及其应用
CN109666646A (zh) * 2018-11-15 2019-04-23 广东省农业科学院农业生物基因研究中心 一种cd163基因编辑的猪胚胎成纤维细胞系的制备及应用
CN110951745A (zh) * 2019-10-30 2020-04-03 内蒙古大学 Cd163突变基因及其在抑制或阻断猪产生抗体的方法和应用
CA3179710A1 (en) * 2020-05-05 2021-11-11 Andrew Mark CIGAN Methods for improving the health of porcine species by targeted inactivation of cd163

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