BR112022017368A2 - Uso de espectroscopia de iv para avaliar penetração de reagentes em espécime biológico - Google Patents

Uso de espectroscopia de iv para avaliar penetração de reagentes em espécime biológico

Info

Publication number
BR112022017368A2
BR112022017368A2 BR112022017368A BR112022017368A BR112022017368A2 BR 112022017368 A2 BR112022017368 A2 BR 112022017368A2 BR 112022017368 A BR112022017368 A BR 112022017368A BR 112022017368 A BR112022017368 A BR 112022017368A BR 112022017368 A2 BR112022017368 A2 BR 112022017368A2
Authority
BR
Brazil
Prior art keywords
sample
spectroscopy
probe
reagents
biological specimen
Prior art date
Application number
BR112022017368A
Other languages
English (en)
Inventor
D Shah Amit
R Flores Cristina
Original Assignee
Sakura Finetek Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sakura Finetek Usa Inc filed Critical Sakura Finetek Usa Inc
Publication of BR112022017368A2 publication Critical patent/BR112022017368A2/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

USO DE ESPECTROSCOPIA DE IV PARA AVALIAR PENETRAÇÃO DE REAGENTES EM ESPÉCIME BIOLÓGICO. A presente invenção refere-se a aparelhos para medir material de amostra (como amostras de tecidos) e metodologias e instrumentos associados envolvem um sistema ou dispositivo de espectroscopia configurado com um dispositivo de medição de amostra (por exemplo, um dispositivo de medição de amostra de reflexão total atenuada (ATR-IV)) incluindo um cristal que define uma superfície/interface receptora de amostra conectada operativamente a uma fonte de IV e a um detector de IV. A superfície/interface receptora da amostra facilita a avaliação da presença (e opcionalmente da quantidade) de um fixador (por exemplo, formaldeído) no material de amostra, amostras de tecido, por exemplo. As medições são feitas em um ou mais locais dentro de uma estrutura/área de posicionamento da amostra, que pode ser fornecida na forma de uma sonda ou uma estrutura perfurante elevada contendo um ou mais dispositivos de medição de amostras ATR-IV (ou outros). A sonda pode incluir uma estrutura ou mecanismo perfurante em uma extremidade distal (aberta) da sonda configurada para criar uma passagem para um local selecionado (profundidade) dentro do material de amostra de forma minimamente invasiva, de modo que a amostra não seja severamente danificada durante os testes.
BR112022017368A 2020-07-07 2021-03-26 Uso de espectroscopia de iv para avaliar penetração de reagentes em espécime biológico BR112022017368A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16/923,056 US11460400B2 (en) 2020-07-07 2020-07-07 Use of IR spectroscopy to evaluate penetration of reagents into biological specimen
PCT/US2021/024480 WO2022010550A1 (en) 2020-07-07 2021-03-26 Use of ir spectroscopy to evaluate penetration of reagents into biological specimen

Publications (1)

Publication Number Publication Date
BR112022017368A2 true BR112022017368A2 (pt) 2023-01-17

Family

ID=75728887

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022017368A BR112022017368A2 (pt) 2020-07-07 2021-03-26 Uso de espectroscopia de iv para avaliar penetração de reagentes em espécime biológico

Country Status (8)

Country Link
US (1) US11460400B2 (pt)
EP (1) EP4100722A1 (pt)
JP (1) JP7441965B2 (pt)
CN (1) CN115398208A (pt)
AU (1) AU2021305812A1 (pt)
BR (1) BR112022017368A2 (pt)
CA (1) CA3174109A1 (pt)
WO (1) WO2022010550A1 (pt)

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Also Published As

Publication number Publication date
CA3174109A1 (en) 2022-01-13
CN115398208A (zh) 2022-11-25
EP4100722A1 (en) 2022-12-14
JP7441965B2 (ja) 2024-03-01
JP2023529770A (ja) 2023-07-12
US20220011227A1 (en) 2022-01-13
US11460400B2 (en) 2022-10-04
AU2021305812A1 (en) 2022-09-22
WO2022010550A1 (en) 2022-01-13

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