BR112022013878A2 - Anticorpos que ligam integrina avb8 e utilizações dos mesmos - Google Patents

Anticorpos que ligam integrina avb8 e utilizações dos mesmos

Info

Publication number
BR112022013878A2
BR112022013878A2 BR112022013878A BR112022013878A BR112022013878A2 BR 112022013878 A2 BR112022013878 A2 BR 112022013878A2 BR 112022013878 A BR112022013878 A BR 112022013878A BR 112022013878 A BR112022013878 A BR 112022013878A BR 112022013878 A2 BR112022013878 A2 BR 112022013878A2
Authority
BR
Brazil
Prior art keywords
antibodies
bind
avb8 integrin
avb8
integrin
Prior art date
Application number
BR112022013878A
Other languages
English (en)
Inventor
Lou Jianlong
D Marks James
Cheng Yifan
G Campbell Melody
L Baron Jody
L Nishimura Stephen
Cormier Anthony
Ito Saburo
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of BR112022013878A2 publication Critical patent/BR112022013878A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

ANTICORPOS QUE LIGAM INTEGRINA AVB8 E UTILIZAÇÕES DOS MESMOS. A presente invenção refere-se a anticorpos que ligam integrina AvB8 e utilizações dos mesmos.
BR112022013878A 2020-01-15 2021-01-15 Anticorpos que ligam integrina avb8 e utilizações dos mesmos BR112022013878A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062961625P 2020-01-15 2020-01-15
US202063017868P 2020-04-30 2020-04-30
PCT/US2021/013720 WO2021146614A2 (en) 2020-01-15 2021-01-15 Antibodies that bind integrin avb8 and uses thereof

Publications (1)

Publication Number Publication Date
BR112022013878A2 true BR112022013878A2 (pt) 2022-09-13

Family

ID=76864194

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022013878A BR112022013878A2 (pt) 2020-01-15 2021-01-15 Anticorpos que ligam integrina avb8 e utilizações dos mesmos

Country Status (11)

Country Link
US (2) US11608378B2 (pt)
EP (1) EP4090683A4 (pt)
JP (1) JP2023511554A (pt)
KR (1) KR20220127858A (pt)
CN (1) CN115335400A (pt)
AU (1) AU2021209117A1 (pt)
BR (1) BR112022013878A2 (pt)
CA (1) CA3171172A1 (pt)
IL (1) IL293856A (pt)
MX (1) MX2022008684A (pt)
WO (1) WO2021146614A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023244547A1 (en) * 2022-06-13 2023-12-21 The Regents Of The University Of California Humanized antibodies to human integrin avb8
CN117143241B (zh) * 2023-10-26 2024-02-23 迈威(上海)生物科技股份有限公司 与人整合素蛋白itgav/itgb8特异性结合的单克隆抗体
CN117126282B (zh) * 2023-10-26 2024-01-12 迈威(上海)生物科技股份有限公司 抗体及其在制备阻断αvβ8与Latent TGF-β的结合的药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2823648T3 (es) * 2013-04-01 2021-05-07 Univ California Métodos y composiciones para tratar y prevenir enfermedades asociadas con la integrina AVB8
AU2017335991B2 (en) * 2016-09-29 2023-07-06 The Regents Of The University Of California Neutralizing antibodies to the αVβ8 integrin complex for immunotherapy
EP3847194A1 (en) * 2018-09-07 2021-07-14 Pfizer Inc. Anti-avb8 antibodies and compositions and uses thereof

Also Published As

Publication number Publication date
KR20220127858A (ko) 2022-09-20
US11608378B2 (en) 2023-03-21
EP4090683A4 (en) 2024-01-10
AU2021209117A1 (en) 2022-07-07
EP4090683A2 (en) 2022-11-23
US20210277125A1 (en) 2021-09-09
CA3171172A1 (en) 2021-07-22
CN115335400A (zh) 2022-11-11
WO2021146614A2 (en) 2021-07-22
US20230279119A1 (en) 2023-09-07
IL293856A (en) 2022-08-01
MX2022008684A (es) 2022-10-18
JP2023511554A (ja) 2023-03-20

Similar Documents

Publication Publication Date Title
BR112022013878A2 (pt) Anticorpos que ligam integrina avb8 e utilizações dos mesmos
UY35415A (es) Proteínas de unión a antígeno.
PH12019502282A1 (en) Bispecific antibodies specifically binding to pd1 and lag3
ECSP17081420A (es) Anticuerpos heterodiméricos que se unen a cd3 y a antígenos tumorales
MA49457A (fr) Molécules d'anticorps se liant à cd73 et leurs utilisations
BR112018071276A2 (pt) anticorpos anti-il-33, composições, métodos e usos dos mesmos
CY1124384T1 (el) Κατασκευες διπλοειδικων αντισωματων που δεσμευονται σε egfrviii και cd3
CO2018000104A2 (es) Moléculas de anticuerpo que se unen a cd22
BR112018067458A2 (pt) anticorpos para tigit
UY37083A (es) Anticuerpos anti-ror1, anticuerpos biespecíficos ror1 x cd3 y métodos para su uso
ECSP17040521A (es) Anticuerpos heterodiméricos que se unen a CD3 y a antígenos tumorales
BR112018010891A2 (pt) anticorpos e fragmentos de anticorpos para a conjugação específica do sítio
EA202190542A1 (ru) Сконструированные биспецифические белки
CO2018000410A2 (es) Moléculas de anticuerpo que se unen a cd79
BR112022018949A2 (pt) Anticorpos monoclonais humanos para síndrome respiratória aguda grave coronavírus 2 (sars-cov-2)
CO2018009533A2 (es) Conjugados de amanitina
BR112018014150A2 (pt) anticorpos monoclonais humanizados imunoestimulantes contra interleucina-2 humana, e proteínas de fusão dos mesmos
BR112018070948A2 (pt) anticorpos anti-psma e utilização dos mesmos
TR201910348T4 (tr) Matriks metalloproteinaz 9 için antikorlar.
BR112013021562A2 (pt) anticorpos para cd70
BR112021020999A2 (pt) Polipeptídeos de ligação à clec12a e usos dos mesmos
CY1125793T1 (el) Εξουδετερωτικα μορια δεσμευσης κατα της γριπης και χρησεις αυτων
MA52190A (fr) Anticorps anti-trem-1 et utilisations associées
BR112021023540A2 (pt) Agentes de afinidade
BR112023017728A2 (pt) Anticorpos anti-nectin-4 e uso dos mesmos

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]