BR112022012846A2 - Métodos de tratamento de condições relacionadas ao receptor s1p1 - Google Patents
Métodos de tratamento de condições relacionadas ao receptor s1p1Info
- Publication number
- BR112022012846A2 BR112022012846A2 BR112022012846A BR112022012846A BR112022012846A2 BR 112022012846 A2 BR112022012846 A2 BR 112022012846A2 BR 112022012846 A BR112022012846 A BR 112022012846A BR 112022012846 A BR112022012846 A BR 112022012846A BR 112022012846 A2 BR112022012846 A2 BR 112022012846A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- treatment
- conditions related
- receiver
- acid
- Prior art date
Links
- 102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 title 1
- 101710155454 Sphingosine 1-phosphate receptor 1 Proteins 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000004631 alopecia areata Diseases 0.000 abstract 1
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Heat Treatment Of Sheet Steel (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
- Medicinal Preparation (AREA)
Abstract
MÉTODOS DE TRATAMENTO DE CONDIÇÕES RELACIONADAS AO RECEPTOR S1P1. A presente invenção refere-se a métodos de tratamento de alopecia areata que compreendem prescrever e/ou administrar a um indivíduo em necessidade do mesmo uma dose padrão de ácido (R)-2-(7-(4-ciclopentil-3-(trifluormetil)benzilóxi)-1,2,3,4-tetra-hidrociclopenta[b]indol-3-il)acético (Composto 1), ou um sal farmaceuticamente aceitável do mesmo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062957535P | 2020-01-06 | 2020-01-06 | |
PCT/US2021/012367 WO2021142030A1 (en) | 2020-01-06 | 2021-01-06 | Methods of treating conditions related to the s1p1 receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022012846A2 true BR112022012846A2 (pt) | 2022-09-06 |
Family
ID=76788331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022012846A BR112022012846A2 (pt) | 2020-01-06 | 2021-01-06 | Métodos de tratamento de condições relacionadas ao receptor s1p1 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230338336A1 (pt) |
EP (1) | EP4087562A4 (pt) |
JP (1) | JP2023509698A (pt) |
KR (1) | KR20220124209A (pt) |
CN (1) | CN115066242A (pt) |
AU (1) | AU2021205465A1 (pt) |
BR (1) | BR112022012846A2 (pt) |
CA (1) | CA3166828A1 (pt) |
IL (1) | IL294071A (pt) |
MX (1) | MX2022008342A (pt) |
TW (1) | TW202135804A (pt) |
WO (1) | WO2021142030A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023049241A1 (en) * | 2021-09-23 | 2023-03-30 | Bristol-Myers Squibb Company | Methods of treating hair-loss disorders with tyk2 inhibitors |
WO2023135506A1 (en) * | 2022-01-13 | 2023-07-20 | Arena Pharmaceuticals, Inc. | Etrasimod for use in treating s1p1 receptor-associated disorders in combination with hormone treatment |
CA3213748A1 (en) | 2022-10-21 | 2023-12-08 | Bongyong Lee | Pharmaceutical composition for preventing or treating alopecia areata acting as a functional antagonist for s1pr1 and s1pr4 |
KR102541577B1 (ko) * | 2022-10-21 | 2023-06-13 | 주식회사 넥스트젠바이오사이언스 | S1pr1과 s1pr4에 대한 기능적 저해제로 작용하는 원형 탈모증의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003061567A2 (en) * | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Selective s1p1/edg1 receptor agonists |
BR112012011427B8 (pt) * | 2009-11-13 | 2021-05-25 | Celgene Int Ii Sarl | moduladores seletivos de receptor de esfingosina 1 fosfato, seu uso, e composição |
US9198911B2 (en) * | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
AU2016205361C1 (en) * | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
US11534424B2 (en) * | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
-
2021
- 2021-01-06 KR KR1020227026729A patent/KR20220124209A/ko active Search and Examination
- 2021-01-06 MX MX2022008342A patent/MX2022008342A/es unknown
- 2021-01-06 CA CA3166828A patent/CA3166828A1/en active Pending
- 2021-01-06 IL IL294071A patent/IL294071A/en unknown
- 2021-01-06 CN CN202180013704.0A patent/CN115066242A/zh active Pending
- 2021-01-06 WO PCT/US2021/012367 patent/WO2021142030A1/en unknown
- 2021-01-06 EP EP21738729.9A patent/EP4087562A4/en active Pending
- 2021-01-06 TW TW110100496A patent/TW202135804A/zh unknown
- 2021-01-06 JP JP2022541198A patent/JP2023509698A/ja active Pending
- 2021-01-06 AU AU2021205465A patent/AU2021205465A1/en active Pending
- 2021-01-06 BR BR112022012846A patent/BR112022012846A2/pt unknown
- 2021-01-06 US US17/790,632 patent/US20230338336A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL294071A (en) | 2022-08-01 |
MX2022008342A (es) | 2022-08-04 |
CA3166828A1 (en) | 2021-07-15 |
WO2021142030A1 (en) | 2021-07-15 |
KR20220124209A (ko) | 2022-09-13 |
JP2023509698A (ja) | 2023-03-09 |
AU2021205465A1 (en) | 2022-07-14 |
CN115066242A (zh) | 2022-09-16 |
TW202135804A (zh) | 2021-10-01 |
EP4087562A4 (en) | 2024-01-10 |
EP4087562A1 (en) | 2022-11-16 |
US20230338336A1 (en) | 2023-10-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022012846A2 (pt) | Métodos de tratamento de condições relacionadas ao receptor s1p1 | |
EA202090955A1 (ru) | Способы применения ингибиторов ehmt2 в лечении или предупреждении нарушений со стороны крови | |
CY1118313T1 (el) | Παραγωγα καρβοστυρυλιου και σταθεροποιητες της διαθεσης για αντιμετωπιση διαταραχων της διαθεσης | |
NI201100147A (es) | Métodos para tratar infartos agudos de miocardio y trastornos relacionados. | |
EA201000603A1 (ru) | ПРИМЕНЕНИЕ АНТИТЕЛ К TrkB ДЛЯ ЛЕЧЕНИЯ РЕСПИРАТОРНЫХ НАРУШЕНИЙ | |
BR0211119A (pt) | Composto, método de tratar um paciente que tenha, ou de prevenir um paciente de pegar, uma doença ou condição, uso de um composto, e, método para fabricar um composto | |
MX2020013157A (es) | Métodos de tratamiento de afecciones relacionadas con el receptor s1p1. | |
AU2003256755A8 (en) | Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations | |
BR0011823A (pt) | Derivado de benzimidazol, composto, composição farmacêutica, uso de um derivado de benzimidazol, e, método para tratamento, prevenção ou alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo animal vivo | |
MX2009002921A (es) | Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico. | |
MA40769B1 (fr) | Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue | |
MX2022008181A (es) | Composiciones farmaceuticas que comprenden un compuesto de dextrometorfano y quinidina para el tratamiento de agitacion en demencia. | |
JOP20190008A1 (ar) | علاج ومنع اضطرابات النوم | |
WO2020033838A3 (en) | Treatment of egfr-mutant cancer | |
MX2021015854A (es) | Composiciones y métodos para tratar trastornos del snc. | |
BRPI0515954A (pt) | composto e sais farmaceuticamente aceitáveis do mesmo e enanciÈmeros e diaestereÈmeros individuais do mesmo, composição farmacêutica, e, métodos para inibição do transportador de glicina glyt1 em um mamìfero, para a fabricação de um medicamento para inibir o transportador de glicina glyt1 em um mamìfero, para tratar um distúbios neurológicos e psiquiátricos associados com disfunçao de neurotransmissão glicinérgica ou glutamatérgica em um paciente mamìfero e para tratar esquizofrenia em um paciente mamìfero | |
BR112022007348A2 (pt) | Métodos para tratar condições relacionadas ao receptor s1p1 | |
CA2986891C (en) | Compositions for use in treating parkinson's disease and related disorders | |
BR112021006318A2 (pt) | terapia de combinação para o tratamento de câncer | |
CY1124236T1 (el) | Διαλυμα εγχυσης λεβοντοπα | |
BR112012020185A2 (pt) | uso de preparações de heparina oral para tratar doenças e afecções do trato urinário. | |
BR112022005999A2 (pt) | Métodos de tratamento de condições relacionadas ao receptor s1p1 | |
BR0312929A (pt) | Uso de um composto, e, métodos de tratamento, prevenção ou alìvio de uma doença, distúrbio ou condição de um corpo de animal vivo, e da degeneração macular relacionada com a idade de um corpo de animal vivo | |
EA202290027A1 (ru) | Способы и композиции для улучшения результатов лечения пациентов с раком | |
BR112019000509A2 (pt) | composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved |
Owner name: ARENA PHARMACEUTICALS, INC. (US) |