BR112022012255A2 - Formulações injetáveis de ação prolongada de sais de pamoato de cetamina - Google Patents
Formulações injetáveis de ação prolongada de sais de pamoato de cetaminaInfo
- Publication number
- BR112022012255A2 BR112022012255A2 BR112022012255A BR112022012255A BR112022012255A2 BR 112022012255 A2 BR112022012255 A2 BR 112022012255A2 BR 112022012255 A BR112022012255 A BR 112022012255A BR 112022012255 A BR112022012255 A BR 112022012255A BR 112022012255 A2 BR112022012255 A2 BR 112022012255A2
- Authority
- BR
- Brazil
- Prior art keywords
- long
- injectable formulations
- ketamine pamoate
- acting injectable
- pamoate salts
- Prior art date
Links
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003299 ketamine Drugs 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000007972 injectable composition Substances 0.000 title abstract 2
- 238000013268 sustained release Methods 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FORMULAÇÕES INJETÁVEIS DE AÇÃO PROLONGADA DE SAIS DE PAMOATO DE CETAMINA. São providas composições farmacêuticas de liberação sustentada, incluindo um sal de pamoato de cetamina e um carreador farmaceuticamente aceitável do mesmo. As composições incluem suspensão aquosa, solução e sistema de entrega de matriz, que podem proporcionar uma liberação sustentada para anestesia, analgesia ou tratamento de doenças do sistema nervoso central e anti-inflamatórias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962951061P | 2019-12-20 | 2019-12-20 | |
PCT/CN2020/137496 WO2021121366A1 (en) | 2019-12-20 | 2020-12-18 | Long-acting injectable formulations of ketamine pamoate salts |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022012255A2 true BR112022012255A2 (pt) | 2022-08-30 |
Family
ID=76478186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022012255A BR112022012255A2 (pt) | 2019-12-20 | 2020-12-18 | Formulações injetáveis de ação prolongada de sais de pamoato de cetamina |
Country Status (15)
Country | Link |
---|---|
US (1) | US20240099994A1 (pt) |
EP (1) | EP4076410A4 (pt) |
JP (1) | JP2023505963A (pt) |
KR (1) | KR20220118427A (pt) |
AR (1) | AR120816A1 (pt) |
AU (1) | AU2020410549A1 (pt) |
BR (1) | BR112022012255A2 (pt) |
CA (1) | CA3152593A1 (pt) |
CL (1) | CL2022001636A1 (pt) |
CO (1) | CO2022003543A2 (pt) |
IL (1) | IL294089A (pt) |
MX (1) | MX2022006596A (pt) |
PE (1) | PE20231942A1 (pt) |
TW (1) | TW202135782A (pt) |
WO (1) | WO2021121366A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111936127A (zh) | 2018-02-15 | 2020-11-13 | 国立大学法人千叶大学 | 炎症性疾病或骨病的预防或治疗剂及医药组合物 |
MX2020011653A (es) | 2018-05-04 | 2021-02-09 | Perception Neuroscience Inc | Métodos de tratamiento para el abuso de sustancias. |
WO2023178039A1 (en) * | 2022-03-14 | 2023-09-21 | Perception Neuroscience, Inc. | Pharmaceutical formulations of r-ketamine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2968221T (lt) * | 2013-03-15 | 2019-07-25 | Janssen Pharmaceutica Nv | S-ketamino hidrochlorido farmacinė kompozicija |
RU2021114918A (ru) * | 2016-12-26 | 2021-07-09 | Целликс Био Прайвет Лимитед | Композиции и способы лечения хронической боли |
WO2019073408A1 (en) * | 2017-10-10 | 2019-04-18 | Douglas Pharmaceuticals Ltd. | PROLONGED RELEASE PHARMACEUTICAL FORMULATION AND TREATMENT METHODS |
WO2019172920A1 (en) * | 2018-03-09 | 2019-09-12 | Rk Pharmaceuticals, Llc | Injectable composition for controlled-release of active ingredient to manage postoperative pain or neuropathic back pain |
WO2019186357A1 (en) * | 2018-03-26 | 2019-10-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
KR20210116517A (ko) * | 2019-01-11 | 2021-09-27 | 에일러 파마슈티컬스 아이엔씨. | 케타민 파모에이트 및 이의 용도 |
-
2020
- 2020-12-18 BR BR112022012255A patent/BR112022012255A2/pt unknown
- 2020-12-18 KR KR1020227020779A patent/KR20220118427A/ko active Search and Examination
- 2020-12-18 PE PE2022000484A patent/PE20231942A1/es unknown
- 2020-12-18 MX MX2022006596A patent/MX2022006596A/es unknown
- 2020-12-18 US US17/754,738 patent/US20240099994A1/en active Pending
- 2020-12-18 IL IL294089A patent/IL294089A/en unknown
- 2020-12-18 AR ARP200103549A patent/AR120816A1/es unknown
- 2020-12-18 JP JP2022531055A patent/JP2023505963A/ja active Pending
- 2020-12-18 AU AU2020410549A patent/AU2020410549A1/en active Pending
- 2020-12-18 EP EP20901388.7A patent/EP4076410A4/en active Pending
- 2020-12-18 WO PCT/CN2020/137496 patent/WO2021121366A1/en active Application Filing
- 2020-12-18 TW TW109145042A patent/TW202135782A/zh unknown
- 2020-12-18 CA CA3152593A patent/CA3152593A1/en active Pending
-
2022
- 2022-03-25 CO CONC2022/0003543A patent/CO2022003543A2/es unknown
- 2022-06-16 CL CL2022001636A patent/CL2022001636A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
PE20231942A1 (es) | 2023-12-05 |
CL2022001636A1 (es) | 2023-01-27 |
EP4076410A1 (en) | 2022-10-26 |
US20240099994A1 (en) | 2024-03-28 |
EP4076410A4 (en) | 2024-02-07 |
AR120816A1 (es) | 2022-03-23 |
WO2021121366A1 (en) | 2021-06-24 |
MX2022006596A (es) | 2022-07-05 |
CN114340603A (zh) | 2022-04-12 |
CA3152593A1 (en) | 2021-06-24 |
CO2022003543A2 (es) | 2022-04-19 |
KR20220118427A (ko) | 2022-08-25 |
TW202135782A (zh) | 2021-10-01 |
JP2023505963A (ja) | 2023-02-14 |
AU2020410549A1 (en) | 2022-04-14 |
IL294089A (en) | 2022-08-01 |
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