BR112022010862A2 - Micro-organismo e método para a produção fermentativa de ácido guanidino acético (gaa) e de creatina - Google Patents
Micro-organismo e método para a produção fermentativa de ácido guanidino acético (gaa) e de creatinaInfo
- Publication number
- BR112022010862A2 BR112022010862A2 BR112022010862A BR112022010862A BR112022010862A2 BR 112022010862 A2 BR112022010862 A2 BR 112022010862A2 BR 112022010862 A BR112022010862 A BR 112022010862A BR 112022010862 A BR112022010862 A BR 112022010862A BR 112022010862 A2 BR112022010862 A2 BR 112022010862A2
- Authority
- BR
- Brazil
- Prior art keywords
- gaa
- creatine
- fermentative production
- micro
- acetic acid
- Prior art date
Links
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 title abstract 14
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 title abstract 6
- 238000012262 fermentative production Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 4
- 229960003624 creatine Drugs 0.000 title abstract 3
- 239000006046 creatine Substances 0.000 title abstract 3
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/04—Amidinotransferases (2.1.4)
- C12Y201/04001—Glycine amidinotransferase (2.1.4.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/02—Amidine-lyases (4.3.2)
- C12Y403/02001—Argininosuccinate lyase (4.3.2.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01002—Guanidinoacetate N-methyltransferase (2.1.1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04005—Argininosuccinate synthase (6.3.4.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
- C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
MICRO-ORGANISMO E MÉTODO PARA A PRODUÇÃO FERMENTATIVA DE ÁCIDO GUANIDINO ACÉTICO (GAA) E DE CREATINA. A presente invenção se refere a um micro-organismo transformado para ser capaz de produzir ácido guanidinoacético (GAA) e a um método para a produção fermentativa de GAA usando tal micro-organismo. A presente invenção também se refere a um método para a produção fermentativa de creatina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19218204.6A EP3839051A1 (en) | 2019-12-19 | 2019-12-19 | Method for the fermentative production of guanidinoacetic acid |
PCT/EP2020/085882 WO2021122400A1 (en) | 2019-12-19 | 2020-12-14 | Method for the fermentative production of guanidinoacetic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022010862A2 true BR112022010862A2 (pt) | 2022-08-23 |
Family
ID=69410969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022010862A BR112022010862A2 (pt) | 2019-12-19 | 2020-12-14 | Micro-organismo e método para a produção fermentativa de ácido guanidino acético (gaa) e de creatina |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP3839051A1 (pt) |
JP (1) | JP2023507482A (pt) |
KR (1) | KR20220119026A (pt) |
CN (1) | CN114867861A (pt) |
AR (1) | AR120771A1 (pt) |
AU (1) | AU2020410242A1 (pt) |
BR (1) | BR112022010862A2 (pt) |
IL (1) | IL293952A (pt) |
MX (1) | MX2022007250A (pt) |
TW (1) | TW202136505A (pt) |
WO (1) | WO2021122400A1 (pt) |
ZA (1) | ZA202207792B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3816247T3 (da) | 2019-10-28 | 2023-02-27 | Evonik Operations Gmbh | Hærderblanding |
CN113481139B (zh) * | 2021-07-29 | 2022-11-08 | 江南大学 | 一种产胍基乙酸的重组枯草芽孢杆菌及其构建方法 |
WO2023232583A1 (en) | 2022-06-03 | 2023-12-07 | Evonik Operations Gmbh | Improved biotechnological method for producing guanidino acetic acid (gaa) by using nadh-dependent dehydrogenases |
WO2023232584A1 (en) | 2022-06-03 | 2023-12-07 | Evonik Operations Gmbh | Method for producing guanidino acetic acid (gaa) |
WO2024094481A1 (en) | 2022-11-03 | 2024-05-10 | Evonik Operations Gmbh | Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane exporter protein |
WO2024094483A1 (en) | 2022-11-03 | 2024-05-10 | Evonik Operations Gmbh | Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane transport protein belonging to the amino acid-polyamine-organocation superfamily |
CN116426497B (zh) * | 2023-03-20 | 2023-10-13 | 江南大学 | 一种l-精氨酸-甘氨酸脒基转移酶及其在生产胍基乙酸中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3849250A (en) | 1971-02-26 | 1974-11-19 | Kyowa Hakko Kogyo Kk | Process for producing l-arginine by fermentation |
DE60034843T2 (de) | 1999-06-03 | 2008-01-17 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von L-arginin |
US7160705B2 (en) | 2000-04-28 | 2007-01-09 | Ajinomoto Co., Inc. | Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine |
PT1758463E (pt) | 2004-06-09 | 2008-04-03 | Alzchem Trostberg Gmbh | Ácido guanidinoacético como aditivo para rações para animais |
US20060200870A1 (en) * | 2004-11-24 | 2006-09-07 | Brian Tseng | Methods of treating muscular dystrophy |
JP4595506B2 (ja) * | 2004-11-25 | 2010-12-08 | 味の素株式会社 | L−アミノ酸生産菌及びl−アミノ酸の製造方法 |
KR101835935B1 (ko) | 2014-10-13 | 2018-03-12 | 씨제이제일제당 (주) | L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌의 제조 방법 |
CN106065411B (zh) | 2016-08-10 | 2021-12-07 | 洛阳华荣生物技术有限公司 | 发酵法生产肌酸 |
WO2018079687A1 (en) * | 2016-10-26 | 2018-05-03 | Ajinomoto Co., Inc. | Method for producing objective substance |
-
2019
- 2019-12-19 EP EP19218204.6A patent/EP3839051A1/en not_active Withdrawn
-
2020
- 2020-12-14 BR BR112022010862A patent/BR112022010862A2/pt unknown
- 2020-12-14 KR KR1020227020423A patent/KR20220119026A/ko unknown
- 2020-12-14 MX MX2022007250A patent/MX2022007250A/es unknown
- 2020-12-14 IL IL293952A patent/IL293952A/en unknown
- 2020-12-14 CN CN202080087505.XA patent/CN114867861A/zh active Pending
- 2020-12-14 AU AU2020410242A patent/AU2020410242A1/en active Pending
- 2020-12-14 EP EP20823810.5A patent/EP4077695A1/en active Pending
- 2020-12-14 WO PCT/EP2020/085882 patent/WO2021122400A1/en unknown
- 2020-12-14 JP JP2022537864A patent/JP2023507482A/ja active Pending
- 2020-12-15 AR ARP200103498A patent/AR120771A1/es unknown
- 2020-12-16 TW TW109144374A patent/TW202136505A/zh unknown
-
2022
- 2022-07-13 ZA ZA2022/07792A patent/ZA202207792B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023507482A (ja) | 2023-02-22 |
EP3839051A1 (en) | 2021-06-23 |
IL293952A (en) | 2022-08-01 |
ZA202207792B (en) | 2023-04-26 |
MX2022007250A (es) | 2022-07-13 |
KR20220119026A (ko) | 2022-08-26 |
EP4077695A1 (en) | 2022-10-26 |
CN114867861A (zh) | 2022-08-05 |
WO2021122400A1 (en) | 2021-06-24 |
AU2020410242A1 (en) | 2022-08-11 |
TW202136505A (zh) | 2021-10-01 |
AR120771A1 (es) | 2022-03-16 |
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