MX2022007250A - Procedimiento de produccion fermentativa de acido guanidinoacetico. - Google Patents

Procedimiento de produccion fermentativa de acido guanidinoacetico.

Info

Publication number
MX2022007250A
MX2022007250A MX2022007250A MX2022007250A MX2022007250A MX 2022007250 A MX2022007250 A MX 2022007250A MX 2022007250 A MX2022007250 A MX 2022007250A MX 2022007250 A MX2022007250 A MX 2022007250A MX 2022007250 A MX2022007250 A MX 2022007250A
Authority
MX
Mexico
Prior art keywords
fermentative production
guanidinoacetic acid
gaa
relates
present
Prior art date
Application number
MX2022007250A
Other languages
English (en)
Inventor
Frank Schneider
Frank Jankowitsch
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of MX2022007250A publication Critical patent/MX2022007250A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01002—Guanidinoacetate N-methyltransferase (2.1.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
    • C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/04—Amidinotransferases (2.1.4)
    • C12Y201/04001—Glycine amidinotransferase (2.1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/02—Amidine-lyases (4.3.2)
    • C12Y403/02001—Argininosuccinate lyase (4.3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04005—Argininosuccinate synthase (6.3.4.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a un microorganismo transformado para ser capaz de producir ácido guanidinoacético (GAA) y a un procedimiento de producción fermentativa de GAA usando tal microorganismo. La presente invención también se refiere a un procedimiento de producción fermentativa de creatina.
MX2022007250A 2019-12-19 2020-12-14 Procedimiento de produccion fermentativa de acido guanidinoacetico. MX2022007250A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19218204.6A EP3839051A1 (en) 2019-12-19 2019-12-19 Method for the fermentative production of guanidinoacetic acid
PCT/EP2020/085882 WO2021122400A1 (en) 2019-12-19 2020-12-14 Method for the fermentative production of guanidinoacetic acid

Publications (1)

Publication Number Publication Date
MX2022007250A true MX2022007250A (es) 2022-07-13

Family

ID=69410969

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022007250A MX2022007250A (es) 2019-12-19 2020-12-14 Procedimiento de produccion fermentativa de acido guanidinoacetico.

Country Status (12)

Country Link
EP (2) EP3839051A1 (es)
JP (1) JP2023507482A (es)
KR (1) KR20220119026A (es)
CN (1) CN114867861A (es)
AR (1) AR120771A1 (es)
AU (1) AU2020410242A1 (es)
BR (1) BR112022010862A2 (es)
IL (1) IL293952A (es)
MX (1) MX2022007250A (es)
TW (1) TW202136505A (es)
WO (1) WO2021122400A1 (es)
ZA (1) ZA202207792B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3816247B1 (de) 2019-10-28 2022-12-07 Evonik Operations GmbH Härtermischung
CN113481139B (zh) * 2021-07-29 2022-11-08 江南大学 一种产胍基乙酸的重组枯草芽孢杆菌及其构建方法
WO2023232584A1 (en) 2022-06-03 2023-12-07 Evonik Operations Gmbh Method for producing guanidino acetic acid (gaa)
WO2023232583A1 (en) 2022-06-03 2023-12-07 Evonik Operations Gmbh Improved biotechnological method for producing guanidino acetic acid (gaa) by using nadh-dependent dehydrogenases
WO2024094481A1 (en) 2022-11-03 2024-05-10 Evonik Operations Gmbh Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane exporter protein
WO2024094483A1 (en) 2022-11-03 2024-05-10 Evonik Operations Gmbh Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane transport protein belonging to the amino acid-polyamine-organocation superfamily
CN116426497B (zh) * 2023-03-20 2023-10-13 江南大学 一种l-精氨酸-甘氨酸脒基转移酶及其在生产胍基乙酸中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3849250A (en) 1971-02-26 1974-11-19 Kyowa Hakko Kogyo Kk Process for producing l-arginine by fermentation
EP1057893B1 (en) 1999-06-03 2007-05-16 Ajinomoto Co., Inc. Method for producing L-arginine
US7160705B2 (en) 2000-04-28 2007-01-09 Ajinomoto Co., Inc. Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine
BRPI0511842B1 (pt) 2004-06-09 2014-08-12 Alzchem Trostberg Gmbh Uso de ácido guanidino acético como aditivo para ração animal
US20060200870A1 (en) * 2004-11-24 2006-09-07 Brian Tseng Methods of treating muscular dystrophy
JP4595506B2 (ja) * 2004-11-25 2010-12-08 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造方法
KR101835935B1 (ko) 2014-10-13 2018-03-12 씨제이제일제당 (주) L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌의 제조 방법
CN106065411B (zh) 2016-08-10 2021-12-07 洛阳华荣生物技术有限公司 发酵法生产肌酸
CN109952380B (zh) * 2016-10-26 2023-07-14 味之素株式会社 用于生产目标物质的方法

Also Published As

Publication number Publication date
WO2021122400A1 (en) 2021-06-24
ZA202207792B (en) 2023-04-26
EP3839051A1 (en) 2021-06-23
EP4077695A1 (en) 2022-10-26
BR112022010862A2 (pt) 2022-08-23
TW202136505A (zh) 2021-10-01
KR20220119026A (ko) 2022-08-26
JP2023507482A (ja) 2023-02-22
AR120771A1 (es) 2022-03-16
CN114867861A (zh) 2022-08-05
AU2020410242A1 (en) 2022-08-11
IL293952A (en) 2022-08-01

Similar Documents

Publication Publication Date Title
MX2022007250A (es) Procedimiento de produccion fermentativa de acido guanidinoacetico.
MX2023000342A (es) Metodo para la produccion fermentativa de acido guanidinoacetico.
ZA202301312B (en) Method for the fermentative production of guanidinoacetic acid
MY170507A (en) A microorganism having enhanced l-amino acids productivity and process for producing l-amino acids using the same
BR112012024799A2 (pt) método para a produção de l-ornitina por fermentação
MY185322A (en) Method for producing l-amino acid
MY170632A (en) Recombinant microorganisms with an improved productivity of putrescine and method for producing putrescine using the same
MY166528A (en) Microorganism for simultaneously producing l-amino acid and riboflavin, and method for producing l-amino acid and riboflavin using same
RU2015142261A (ru) Микроорганизмы, продуцирующие путресцин, и способ получения путресцина с использованием этих микроорганизмов
PH12017502396A1 (en) Microorganisms for producing putrescine or ornithine and process for producing putrescine or ornithine using them
BR112020003467B8 (pt) Método para preparar uma composição fermentada, e, composição fermentada
MY189932A (en) Recombinant microorganism for improved production of alanine
PH12020551045A1 (en) A microorganism of the genus corynebacterium producing l-amino acids and method for producing l-amino acids using the same
MY181203A (en) Microorganism of corynebacterium sp. having enhanced l-lysine producibility and method for producing l-lysine using same
MX2020008809A (es) Un microorganismo que produce un aminoácido similar a la micosporina y un procedimiento de producción de un aminoácido similar a la micosporina mediante el uso del mismo.
ATE505553T1 (de) Unterart von corynebacterium glutamicum zur erzeugung von l-arginin and und verfahren zu ihrer herstellung
PH12020500328A1 (en) Microorganism for producing a mycosporine-like amino acid and method for producing a mycosporine-like amino acid using the same
MY171648A (en) Microorganism producing l-lysine and method for producing l-lysine using the same
MY169049A (en) Microorganisms for producing putrescine and process for producing putrescine using them
MX2019000075A (es) Metodo para la produccion fermentativa de moleculas de interes por microorganismos que comprenden genes que codifican el sistema de fosfotransferasa de azucar (pts).
BR112023024041A2 (pt) Micro-organismo, e método para a produção fermentativa de ácido guanidinoacético (gaa) e creatina
WO2010101360A3 (ko) Ｌ-아미노산 생산 미생물 및 이를 이용한 ｌ-아미노산 생산 방법
MX2021012296A (es) Microorganismo que produce l-aminoacido y procedimiento de produccion de l-aminoacido mediante el uso del mismo.
WO2011083933A3 (ko) Ｌ-오르니틴 또는 ｌ-아르기닌 생산 변이주 및 이의 제조방법
EA033071B1 (ru) Способ увеличения выхода продуктов из ацетолактата