BR112022006863A8 - Sistemas e métodos de isolamento de gálio-68 - Google Patents
Sistemas e métodos de isolamento de gálio-68Info
- Publication number
- BR112022006863A8 BR112022006863A8 BR112022006863A BR112022006863A BR112022006863A8 BR 112022006863 A8 BR112022006863 A8 BR 112022006863A8 BR 112022006863 A BR112022006863 A BR 112022006863A BR 112022006863 A BR112022006863 A BR 112022006863A BR 112022006863 A8 BR112022006863 A8 BR 112022006863A8
- Authority
- BR
- Brazil
- Prior art keywords
- gallium
- methods
- insulation systems
- systems
- target
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 title abstract 2
- 238000009413 insulation Methods 0.000 title 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/265—Adsorption chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/02—Column or bed processes
- B01J47/026—Column or bed processes using columns or beds of different ion exchange materials in series
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0021—Gallium
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Catalysts (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Recrystallisation Techniques (AREA)
Abstract
SISTEMAS E MÉTODOS DE ISOLAMENTO DE GÁLIO-68. Trata-se de um processo para a preparação de uma solução de Ga-68 livre de carreador a partir de um alvo de Zn irradiado, sistemas que compreendem componentes usados no processo e composições que compreendem Ga-68 preparadas pelo processo. Purificação de Ga-68 é realizada alimentando-se uma solução de alvo de irradiação que compreende Zn-68, Ga-68 e metais de conjunto de alvo sólido em um sistema que compreende três colunas de cromatografia em sucessão.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962914476P | 2019-10-12 | 2019-10-12 | |
PCT/IB2020/059581 WO2021070164A1 (en) | 2019-10-12 | 2020-10-12 | Systems and methods of isolation of gallium-68 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112022006863A2 BR112022006863A2 (pt) | 2022-07-05 |
BR112022006863A8 true BR112022006863A8 (pt) | 2022-08-02 |
Family
ID=75438061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022006863A BR112022006863A8 (pt) | 2019-10-12 | 2020-10-12 | Sistemas e métodos de isolamento de gálio-68 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220351873A1 (pt) |
EP (1) | EP4041426A4 (pt) |
JP (1) | JP2022551697A (pt) |
KR (1) | KR20220093127A (pt) |
CN (1) | CN114761100A (pt) |
AU (1) | AU2020364423A1 (pt) |
BR (1) | BR112022006863A8 (pt) |
CA (1) | CA3156951A1 (pt) |
CR (1) | CR20220208A (pt) |
WO (1) | WO2021070164A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116594053B (zh) * | 2023-07-18 | 2024-01-19 | 清华大学 | 放射性溶液中超铀α核素、90Sr和137Cs的组分离系统及装置 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2461681A1 (fr) * | 1979-07-20 | 1981-02-06 | Rhone Poulenc Ind | Perfectionnement au procede de recuperation de l'uranium d'un acide phosphorique impur |
US5326441A (en) * | 1990-01-19 | 1994-07-05 | European Economic Community | Process for separating and concentrating gallium from an aqueous solution containing gallium, together with aluminum, zinc and copper |
GB0308407D0 (en) * | 2003-04-11 | 2003-05-21 | Amersham Plc | Method of obtaining 68 GA |
TW200740709A (en) * | 2005-07-26 | 2007-11-01 | Dro Biosystems S L | Static support bed for purification, separation, detection, modification and/or immobilization of target entities and method using thereof |
JP2012513373A (ja) * | 2008-12-22 | 2012-06-14 | バイエル ファーマ アクチエンゲゼルシャフト | 放射性核種標識化合物の合成方法 |
FR3019547B1 (fr) * | 2014-04-03 | 2017-12-22 | Univ Paris Sud 11 | Nouveaux complexes pour la separation de cations |
JP2017521645A (ja) * | 2014-05-15 | 2017-08-03 | メイヨ フォンデーシヨン フォー メディカル エジュケーション アンド リサーチ | 放射性金属のサイクロトロン生成用の溶液ターゲット |
EP3101660B1 (en) * | 2015-06-05 | 2017-08-09 | Universidade de Coimbra | Process for producing gallium-68 through the irradiation of a solution target |
JP7079494B2 (ja) * | 2016-04-01 | 2022-06-02 | 国立大学法人 東京大学 | 新規化合物とその合成方法 |
US11446398B2 (en) * | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
EP3503929B1 (en) * | 2016-08-26 | 2022-02-23 | Mayo Foundation for Medical Education and Research | Rapid isolation of cyclotron-produced gallium-68 |
KR20200044005A (ko) * | 2017-07-31 | 2020-04-28 | 스테판 제이슬러 | 고체 타겟을 사용하여 입자 가속기 상에서 갈륨 방사성 동위 원소를 생산하기 위한 시스템, 장치 및 방법과, 이에 의해 생산된 ga-68 조성물 |
WO2020118426A1 (en) * | 2018-12-11 | 2020-06-18 | Societe de Commercialisation des Produits de la Recherche Appliquée Socpra Sciences et Génie S.E.C. | Processes and systems for producing and/or purifying gallium-68 |
-
2020
- 2020-10-12 EP EP20874202.3A patent/EP4041426A4/en not_active Withdrawn
- 2020-10-12 BR BR112022006863A patent/BR112022006863A8/pt not_active Application Discontinuation
- 2020-10-12 WO PCT/IB2020/059581 patent/WO2021070164A1/en active Application Filing
- 2020-10-12 US US17/767,039 patent/US20220351873A1/en active Pending
- 2020-10-12 JP JP2022521634A patent/JP2022551697A/ja active Pending
- 2020-10-12 KR KR1020227015702A patent/KR20220093127A/ko unknown
- 2020-10-12 CA CA3156951A patent/CA3156951A1/en active Pending
- 2020-10-12 CN CN202080072686.9A patent/CN114761100A/zh active Pending
- 2020-10-12 CR CR20220208A patent/CR20220208A/es unknown
- 2020-10-12 AU AU2020364423A patent/AU2020364423A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022551697A (ja) | 2022-12-13 |
US20220351873A1 (en) | 2022-11-03 |
WO2021070164A1 (en) | 2021-04-15 |
EP4041426A1 (en) | 2022-08-17 |
EP4041426A4 (en) | 2022-11-23 |
BR112022006863A2 (pt) | 2022-07-05 |
CN114761100A (zh) | 2022-07-15 |
KR20220093127A (ko) | 2022-07-05 |
CA3156951A1 (en) | 2021-04-15 |
AU2020364423A1 (en) | 2022-04-21 |
CR20220208A (es) | 2022-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |