BR112022003712A2 - Derivado de interleucina-2 - Google Patents
Derivado de interleucina-2Info
- Publication number
- BR112022003712A2 BR112022003712A2 BR112022003712A BR112022003712A BR112022003712A2 BR 112022003712 A2 BR112022003712 A2 BR 112022003712A2 BR 112022003712 A BR112022003712 A BR 112022003712A BR 112022003712 A BR112022003712 A BR 112022003712A BR 112022003712 A2 BR112022003712 A2 BR 112022003712A2
- Authority
- BR
- Brazil
- Prior art keywords
- derivative
- cysteine residue
- complex
- blocking module
- interleukin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
DERIVADO DE INTERLEUCINA-2. Trata-se de um derivado de IL-2. Introduzindo-se pelo menos um resíduo de cisteína com base em IL-2 de tipo selvagem, o plano de ligação do derivado de IL-2 e uma subunidade receptora a é parcialmente ou completamente bloqueado, enquanto a afinidade do derivado de IL-2 ao complexo de subunidades receptoras ß e y é basicamente retida. -Um complexo também é revelado, que compreende: um derivado de IL-2, que é introduzido com um terceiro resíduo de cisteína com base em IL-2 de tipo selvagem; e um módulo de bloqueio, que tem ou é introduzido com um quarto resíduo de cisteína; em que o terceiro resíduo de cisteína no derivado de IL-2 e o quarto resíduo de cisteína no módulo de bloqueio são capazes de formar uma ligação de dissulfeto intermolecular, formando, assim, um complexo do derivado de IL-2 e do módulo de bloqueio; e em que o plano de ligação da subunidade receptora de derivado de IL-2 e a é parcialmente ou completamente bloqueado, enquanto a afinidade do derivado de IL-2 ao complexo de subunidades receptoras ß e y é basicamente retida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911302355.5A CN111018961B (zh) | 2019-12-17 | 2019-12-17 | 白介素-2衍生物 |
| PCT/CN2020/070748 WO2021120350A1 (zh) | 2019-12-17 | 2020-01-07 | 白介素-2衍生物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022003712A2 true BR112022003712A2 (pt) | 2022-10-11 |
Family
ID=70210189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022003712A BR112022003712A2 (pt) | 2019-12-17 | 2020-01-07 | Derivado de interleucina-2 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220363731A1 (pt) |
| EP (1) | EP4023666A4 (pt) |
| JP (1) | JP2023514003A (pt) |
| KR (1) | KR20220113918A (pt) |
| CN (4) | CN114437198A (pt) |
| AU (1) | AU2020406768A1 (pt) |
| BR (1) | BR112022003712A2 (pt) |
| CA (1) | CA3151681A1 (pt) |
| GB (1) | GB2604238A (pt) |
| MX (1) | MX2022003301A (pt) |
| WO (1) | WO2021120350A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022011893A (es) | 2020-03-31 | 2022-10-18 | Hanmi Pharm Ind Co Ltd | Nuevos analogos de il-2 inmunoestimuladores. |
| EP4139341A1 (en) * | 2020-04-21 | 2023-03-01 | Regeneron Pharmaceuticals, Inc. | Il-2 variants with reduced binding to il-2 receptor alpha and uses thereof |
| TW202210502A (zh) | 2020-06-03 | 2022-03-16 | 丹麥商阿森迪斯腫瘤製藥有限公司 | 新穎il-2序列及其用途 |
| CN114380919A (zh) | 2020-10-18 | 2022-04-22 | 北京志道生物科技有限公司 | 经修饰的il-2分子及其用途 |
| CN114369153A (zh) * | 2020-10-18 | 2022-04-19 | 北京志道生物科技有限公司 | 一种白介素-2突变体 |
| WO2023046156A1 (en) * | 2021-09-26 | 2023-03-30 | Wuxi Biologics (Shanghai) Co. Ltd. | Il-2 variants and fusion proteins thereof |
| CN114306576A (zh) * | 2022-01-11 | 2022-04-12 | 北京志道生物科技有限公司 | 一种防止il-2衍生物蛋白复合体聚集及非共价连接蛋白亚基脱落的制剂 |
| CN114349843B (zh) * | 2022-01-18 | 2024-05-14 | 浙江博锐生物制药有限公司 | 白细胞介素-2衍生物及其制备方法和应用 |
| CN116041539B (zh) * | 2022-10-31 | 2023-07-21 | 山东博安生物技术股份有限公司 | Il-2突变体免疫缀合物 |
| WO2024104444A1 (zh) * | 2022-11-17 | 2024-05-23 | 南通壹宸生物医药科技有限公司 | Il-2突变体及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1208345C (zh) * | 2002-07-23 | 2005-06-29 | 重庆大学 | 重组人白细胞介素－2的三突变体及制备方法 |
| AU2007271398B2 (en) | 2006-07-06 | 2013-06-20 | Merck Patent Gmbh | Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses |
| SI2673294T1 (sl) | 2011-02-10 | 2016-08-31 | Roche Glycart Ag | Mutirani polipeptidi interlevkina-2 |
| NZ728175A (en) * | 2014-08-11 | 2023-03-31 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| WO2019028425A1 (en) * | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | CONJUGATES OF CYTOKINE FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
| WO2019091384A1 (en) * | 2017-11-08 | 2019-05-16 | Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. | Conjugates of biomolecule and use thereof |
| CA3086842A1 (en) * | 2017-12-27 | 2019-07-04 | Kyowa Kirin Co., Ltd. | Il-2 variant |
| EP3773680A1 (en) * | 2018-03-28 | 2021-02-17 | Ascendis Pharma Oncology Division A/S | Il-2 conjugates |
| CA3136992A1 (en) * | 2019-05-24 | 2020-12-03 | Proviva Therapeutics (Hong Kong) Limited | Il-2 compositions and methods of use thereof |
-
2019
- 2019-12-17 CN CN202210110228.0A patent/CN114437198A/zh active Pending
- 2019-12-17 CN CN201911302355.5A patent/CN111018961B/zh active Active
- 2019-12-17 CN CN202210176105.7A patent/CN114524873A/zh active Pending
- 2019-12-17 CN CN202210110617.3A patent/CN114478743A/zh active Pending
-
2020
- 2020-01-07 MX MX2022003301A patent/MX2022003301A/es unknown
- 2020-01-07 CA CA3151681A patent/CA3151681A1/en active Pending
- 2020-01-07 BR BR112022003712A patent/BR112022003712A2/pt unknown
- 2020-01-07 EP EP20901536.1A patent/EP4023666A4/en active Pending
- 2020-01-07 US US17/771,032 patent/US20220363731A1/en active Pending
- 2020-01-07 WO PCT/CN2020/070748 patent/WO2021120350A1/zh unknown
- 2020-01-07 AU AU2020406768A patent/AU2020406768A1/en active Pending
- 2020-01-07 KR KR1020227008663A patent/KR20220113918A/ko unknown
- 2020-01-07 GB GB2201999.6A patent/GB2604238A/en active Pending
- 2020-01-07 JP JP2022535594A patent/JP2023514003A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN114437198A (zh) | 2022-05-06 |
| CN111018961A (zh) | 2020-04-17 |
| EP4023666A4 (en) | 2023-03-22 |
| CN114524873A (zh) | 2022-05-24 |
| CN111018961B (zh) | 2022-03-18 |
| CA3151681A1 (en) | 2021-06-24 |
| MX2022003301A (es) | 2022-04-12 |
| EP4023666A1 (en) | 2022-07-06 |
| GB202201999D0 (en) | 2022-03-30 |
| US20220363731A1 (en) | 2022-11-17 |
| GB2604238A (en) | 2022-08-31 |
| JP2023514003A (ja) | 2023-04-05 |
| WO2021120350A1 (zh) | 2021-06-24 |
| KR20220113918A (ko) | 2022-08-17 |
| AU2020406768A1 (en) | 2022-03-03 |
| CN114478743A (zh) | 2022-05-13 |
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