BR112022003224A2 - Derivação otimizada do analito para aplicação sinérgica com o método de esponja de cristal - Google Patents

Derivação otimizada do analito para aplicação sinérgica com o método de esponja de cristal

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Publication number
BR112022003224A2
BR112022003224A2 BR112022003224A BR112022003224A BR112022003224A2 BR 112022003224 A2 BR112022003224 A2 BR 112022003224A2 BR 112022003224 A BR112022003224 A BR 112022003224A BR 112022003224 A BR112022003224 A BR 112022003224A BR 112022003224 A2 BR112022003224 A2 BR 112022003224A2
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BR
Brazil
Prior art keywords
organic molecule
group
synergic
derivation
application
Prior art date
Application number
BR112022003224A
Other languages
English (en)
Inventor
Hierse Wolfgang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP19194201.0A external-priority patent/EP3786623A1/en
Priority claimed from PCT/EP2019/073021 external-priority patent/WO2021037362A1/en
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR112022003224A2 publication Critical patent/BR112022003224A2/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4022—Concentrating samples by thermal techniques; Phase changes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4044—Concentrating samples by chemical techniques; Digestion; Chemical decomposition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/20008—Constructional details of analysers, e.g. characterised by X-ray source, detector or optical system; Accessories therefor; Preparing specimens therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/207—Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4022—Concentrating samples by thermal techniques; Phase changes
    • G01N2001/4027—Concentrating samples by thermal techniques; Phase changes evaporation leaving a concentrated sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/05—Investigating materials by wave or particle radiation by diffraction, scatter or reflection
    • G01N2223/056—Investigating materials by wave or particle radiation by diffraction, scatter or reflection diffraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

DERIVAÇÃO OTIMIZADA DO ANALITO PARA APLICAÇÃO SINÉRGICA COM O MÉTODO DE ESPONJA DE CRISTAL. A presente invenção refere-se a método de preparação de amostras (100) que inclui: fornecer uma amostra (10) compreendendo uma molécula orgânica (20), em que a molécula orgânica (20) compreende um grupo alvo (21), em que o grupo alvo (21) é um grupo nucleofílico e/ou um grupo ácido; uma etapa de derivação (110) compreendendo: derivação do grupo alvo (21) da molécula orgânica (20) com uma fração (31) compreendendo um ou mais entre (i) um grupo contendo hidrocarboneto e (ii) um grupo contendo um átomo do 3º período, em que o átomo do 3º período é selecionado do grupo composto de Si, P e S, fornecendo assim uma molécula orgânica derivada (30); uma etapa de separação (120) compreendendo: submeter a amostra (10) a um processo de separação para fornecer uma fração (35) compreendendo a molécula orgânica derivada (30); e uma etapa de preparação (130) compreendendo: introduzir a molécula orgânica derivada (30) em um cristal único poroso (40), para fornecer uma molécula orgânica derivada dopada de cristal único poroso (50).
BR112022003224A 2019-08-28 2020-08-26 Derivação otimizada do analito para aplicação sinérgica com o método de esponja de cristal BR112022003224A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19194201.0A EP3786623A1 (en) 2019-08-28 2019-08-28 Optimized analyte derivatization for synergistic application with crystal sponge method
PCT/EP2019/073021 WO2021037362A1 (en) 2019-08-28 2019-08-28 Optimized analyte derivatization for synergistic application with crystal sponge method
PCT/EP2020/073894 WO2021037937A1 (en) 2019-08-28 2020-08-26 Optimized analyte derivatization for synergistic application with crystal sponge method

Publications (1)

Publication Number Publication Date
BR112022003224A2 true BR112022003224A2 (pt) 2022-07-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022003224A BR112022003224A2 (pt) 2019-08-28 2020-08-26 Derivação otimizada do analito para aplicação sinérgica com o método de esponja de cristal

Country Status (11)

Country Link
US (1) US20220276186A1 (pt)
EP (1) EP4022293A1 (pt)
JP (1) JP2022545914A (pt)
KR (1) KR20220047866A (pt)
CN (1) CN114341993A (pt)
AU (1) AU2020335225A1 (pt)
BR (1) BR112022003224A2 (pt)
CA (1) CA3148335A1 (pt)
IL (1) IL290872A (pt)
WO (1) WO2021037937A1 (pt)
ZA (1) ZA202202737B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113311078A (zh) * 2021-04-30 2021-08-27 南京爱可德夫科技开发有限公司 一种检测手性甲氧基醇类的分析方法
CN116333328A (zh) * 2023-02-23 2023-06-27 暨南大学 一种新型铜基吡啶芴晶体海绵的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0704764D0 (en) * 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
US10309035B2 (en) 2014-03-10 2019-06-04 The University Of Tokyo Method of preparing sample for crystal structure analysis, method of determining absolute configuration of chiral compound, and polynuclear metal complex monocrystal
JP6628301B2 (ja) 2015-03-10 2020-01-08 国立大学法人 東京大学 多孔性化合物の単結晶の良否判別方法、解析対象化合物を含む溶液の調製方法、結晶構造解析用試料の作製方法、及び解析対象化合物の分子構造決定方法
US9975114B2 (en) * 2016-05-13 2018-05-22 King Fahd University Of Petroleum And Minerals Metal organic frameworks as catalysts and hydrocarbon oxidation methods thereof

Also Published As

Publication number Publication date
IL290872A (en) 2022-04-01
ZA202202737B (en) 2023-12-20
KR20220047866A (ko) 2022-04-19
EP4022293A1 (en) 2022-07-06
JP2022545914A (ja) 2022-11-01
US20220276186A1 (en) 2022-09-01
CN114341993A (zh) 2022-04-12
AU2020335225A1 (en) 2022-03-10
WO2021037937A1 (en) 2021-03-04
CA3148335A1 (en) 2021-03-04

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