BR112021023635A2 - Novos compostos para inibição de janus quinase 1 - Google Patents

Novos compostos para inibição de janus quinase 1

Info

Publication number
BR112021023635A2
BR112021023635A2 BR112021023635A BR112021023635A BR112021023635A2 BR 112021023635 A2 BR112021023635 A2 BR 112021023635A2 BR 112021023635 A BR112021023635 A BR 112021023635A BR 112021023635 A BR112021023635 A BR 112021023635A BR 112021023635 A2 BR112021023635 A2 BR 112021023635A2
Authority
BR
Brazil
Prior art keywords
janus kinase
novel compounds
compounds
inhibit janus
inhibit
Prior art date
Application number
BR112021023635A
Other languages
English (en)
Portuguese (pt)
Inventor
Pandurang Gunjal Amol
Anil Kumar
Himanshu Rai
Mahadev Bandgar
Iswar PATIL Rakesh
Kumar Rai Santosh
Sazid Ali
Reddy Bapuram Srinivasa
Original Assignee
Mankind Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mankind Pharma Ltd filed Critical Mankind Pharma Ltd
Publication of BR112021023635A2 publication Critical patent/BR112021023635A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR112021023635A 2019-05-28 2020-05-26 Novos compostos para inibição de janus quinase 1 BR112021023635A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201911021098 2019-05-28
PCT/IN2020/050471 WO2020240586A1 (en) 2019-05-28 2020-05-26 Novel compounds for inhibition of janus kinase 1

Publications (1)

Publication Number Publication Date
BR112021023635A2 true BR112021023635A2 (pt) 2022-02-01

Family

ID=73553608

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021023635A BR112021023635A2 (pt) 2019-05-28 2020-05-26 Novos compostos para inibição de janus quinase 1

Country Status (11)

Country Link
US (1) US12516056B2 (https=)
EP (1) EP3976612A4 (https=)
JP (1) JP7592029B2 (https=)
CN (1) CN114174294B (https=)
AU (1) AU2020284742B2 (https=)
BR (1) BR112021023635A2 (https=)
CA (1) CA3141571A1 (https=)
MX (1) MX2021014361A (https=)
TW (1) TWI839524B (https=)
WO (1) WO2020240586A1 (https=)
ZA (1) ZA202109183B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023526521A (ja) * 2020-05-21 2023-06-21 ステムシナジー セラピューティクス， インク． Ｎｏｔｃｈ阻害剤及びそれらの使用
WO2022166796A1 (zh) * 2021-02-05 2022-08-11 上海齐鲁制药研究中心有限公司 嘧啶或吡啶并杂环类腺苷受体抑制剂及其制备方法和用途
PE20250019A1 (es) * 2021-05-06 2025-01-07 Exscientia Ai Ltd MODULADORES DE PKC-theta
WO2022234298A1 (en) * 2021-05-06 2022-11-10 Exscientia Ai Limited Pkc-theta modulators
EP4452944A1 (en) * 2021-12-22 2024-10-30 Icagen, LLC Cyclopropyl compounds
CN117050074B (zh) * 2022-05-05 2025-08-12 中国药科大学 一类吡啶联咪唑并吡啶化合物及其制备方法与用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
UY29825A1 (es) 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones
SG10202003901UA (en) * 2005-12-13 2020-05-28 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
EP2244711A4 (en) * 2008-02-04 2011-08-24 Cytokinetics Inc CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
US20110201599A1 (en) * 2008-07-03 2011-08-18 Exelixis, Inc. CDK Modulators
WO2010036316A1 (en) 2008-09-24 2010-04-01 Yangbo Feng Urea and carbamate compounds and analogs as kinase inhibitors
FI124118B (fi) * 2011-06-13 2014-03-31 Reijo Uolevi Hautalahti Aurinkoenergian avulla sähköä ja lämpöä tuottava voimala
KR20130076046A (ko) * 2011-12-28 2013-07-08 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
ES2567552T3 (es) * 2012-01-30 2016-04-25 Cephalon, Inc. Imidazo [4,5-b] derivados de piridina como los moduladores ALK y JAK para el tratamiento de trastornos proliferativos
CN104140426B (zh) * 2013-05-07 2017-02-01 上海汇伦生命科技有限公司 嘧啶并咪唑类化合物、其药物组合物及其制备方法和用途
US10253023B2 (en) 2014-10-06 2019-04-09 Merck Patent Gmbh Heteroaryl compounds as BTK inhibitors and uses thereof
CN105837572B (zh) 2015-02-02 2019-04-19 四川大学 N-取代苯基酰胺衍生物及其制备方法和用途
CN106146504B (zh) * 2015-04-17 2018-09-07 上海汇伦生命科技有限公司 一种杂环并咪唑类化合物、其药物组合物及其制备方法和用途
ES2830446T3 (es) 2015-12-11 2021-06-03 Sichuan Kelun Biotech Biopharmaceutical Co Ltd Derivado de azetidina, método de preparación del mismo y uso del mismo
CN109641892B (zh) * 2016-08-16 2021-07-02 默克专利有限公司 用作可逆btk抑制剂的2-氧代-咪唑并吡啶及其用途
GB201717260D0 (en) 2017-10-20 2017-12-06 Galapagos Nv Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders
CN113508114B (zh) * 2019-02-27 2024-03-26 四川科伦博泰生物医药股份有限公司 以氮杂环丁烷衍生物为活性成分的口服药物组合物、其制备方法及用途

Also Published As

Publication number Publication date
TW202110838A (zh) 2021-03-16
JP7592029B2 (ja) 2024-11-29
CA3141571A1 (en) 2020-12-03
ZA202109183B (en) 2022-08-31
EP3976612A4 (en) 2023-04-26
US20220235046A1 (en) 2022-07-28
CN114174294A (zh) 2022-03-11
EP3976612A1 (en) 2022-04-06
CN114174294B (zh) 2024-10-25
MX2021014361A (es) 2022-04-06
AU2020284742B2 (en) 2026-03-05
US12516056B2 (en) 2026-01-06
JP2022534510A (ja) 2022-08-01
AU2020284742A1 (en) 2022-02-03
WO2020240586A1 (en) 2020-12-03
TWI839524B (zh) 2024-04-21

Similar Documents

Publication Publication Date Title
BR112021023635A2 (pt) Novos compostos para inibição de janus quinase 1
MX2023001917A (es) Inhibidores de la fosfatasa shp2 y metodos para su uso.
CL2023002276A1 (es) Inhibidores de cdk y métodos de uso de estos
CL2021002882A1 (es) Inhibidores de fgfr y métodos de uso de los mismos
EA201990904A1 (ru) 1,3-дизамещенные производные циклобутана или азетидина в качестве ингибиторов гемопоэтической простагландин-d-синтазы
GEAP202015005A (en) Diacylglycerol acyltransferase 2 inhibitors
JOP20180113A1 (ar) مركبات ,تركيبات وطرق
MX2020009234A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas con receptores de interleucina-1 (irak) tipo ii y usos de los mismos.
CO2021001219A2 (es) Benzimidazoles sustituidos como inhibidores de pad4
CR20220139A (es) Inhibidor de diacilglicerol aciltransferasa 2
BR112013001632A2 (pt) composto, composição farmacêutica, método de inibir uma atividade uma jak quinase in vitro, uso de um composto, ou da composição farmacêutica, e, método de fabricar um composto
CL2021001461A1 (es) Moduladores de trex1
PY1983118A (es) Inhibidores de pde4 que contienen boro
BR112023015210A2 (pt) Inibidores de cdk2 e métodos de uso dos mesmos
EA202091400A1 (ru) Производные пиррола в качестве ингибиторов асс
MX2022002443A (es) Compuestos inhibidores de perk.
EP4706394A3 (en) Use of alkoxypyrazoles as nitrification inhibitors
MX389378B (es) Derivados de amino-imidazopiridina novedosos como inhibidores de cinasa de janus y uso farmacéutico de estos.
AU2018316542A1 (en) Indole derivatives as histone demethylase inhibitors
MX2022006320A (es) Composicion para la inhibicion de la produccion de hmf que comprende disacarido de alulosa.
BR112022010054A2 (pt) Compostos heterocíclicos como inibidores de delta-5 dessaturase e métodos de uso
PH12021550258A1 (en) Cdk8/19 inhibitors
BR112023022917A2 (pt) Moduladores de trex1
MY205163A (en) Silylethynyl hetaryl compounds as nitrification inhibitors
EA202090888A1 (ru) Соединение, обладающее активностью по ингибированию erk киназы, и его применение

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]