BR112023022917A2 - Moduladores de trex1 - Google Patents

Moduladores de trex1

Info

Publication number
BR112023022917A2
BR112023022917A2 BR112023022917A BR112023022917A BR112023022917A2 BR 112023022917 A2 BR112023022917 A2 BR 112023022917A2 BR 112023022917 A BR112023022917 A BR 112023022917A BR 112023022917 A BR112023022917 A BR 112023022917A BR 112023022917 A2 BR112023022917 A2 BR 112023022917A2
Authority
BR
Brazil
Prior art keywords
trex1
modulators
trex
compositions
treating
Prior art date
Application number
BR112023022917A
Other languages
English (en)
Inventor
Aaron Coffin
Avinash Khanna
E Wilson Jonathan
R Levell Julian
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of BR112023022917A2 publication Critical patent/BR112023022917A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Amplifiers (AREA)

Abstract

moduladores de trex1. a invenção refere-se a compostos de fórmula (i) e sais farmaceuticamente aceitáveis e composições dos mesmos, que são úteis para tratamento de uma variedade de condições associadas a trex1.
BR112023022917A 2021-05-05 2022-05-04 Moduladores de trex1 BR112023022917A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163184460P 2021-05-05 2021-05-05
PCT/US2022/027571 WO2022235725A1 (en) 2021-05-05 2022-05-04 Modulators of trex1

Publications (1)

Publication Number Publication Date
BR112023022917A2 true BR112023022917A2 (pt) 2024-01-23

Family

ID=82016366

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022917A BR112023022917A2 (pt) 2021-05-05 2022-05-04 Moduladores de trex1

Country Status (12)

Country Link
EP (1) EP4333985A1 (pt)
JP (1) JP2024516289A (pt)
KR (1) KR20240035385A (pt)
CN (1) CN117561251A (pt)
AU (1) AU2022269596A1 (pt)
BR (1) BR112023022917A2 (pt)
CA (1) CA3217421A1 (pt)
CO (1) CO2023016367A2 (pt)
CR (1) CR20230569A (pt)
DO (1) DOP2023000241A (pt)
IL (1) IL308220A (pt)
WO (1) WO2022235725A1 (pt)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9328075B2 (en) * 2011-05-05 2016-05-03 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for treating influenza
CN104619699A (zh) * 2012-08-06 2015-05-13 萨维拉制药有限公司 二羟基嘧啶碳酸衍生物以及它们在治疗、改善或预防病毒疾病中的用途
LT3891145T (lt) * 2018-12-06 2023-08-10 Constellation Pharmaceuticals, Inc. Trex1 moduliatoriai
KR20220035916A (ko) * 2019-07-23 2022-03-22 콘스텔레이션 파마슈티칼스, 인크. Trex1의 조절제

Also Published As

Publication number Publication date
EP4333985A1 (en) 2024-03-13
WO2022235725A1 (en) 2022-11-10
KR20240035385A (ko) 2024-03-15
DOP2023000241A (es) 2024-02-29
AU2022269596A1 (en) 2023-11-16
CA3217421A1 (en) 2022-11-10
JP2024516289A (ja) 2024-04-12
CN117561251A (zh) 2024-02-13
CO2023016367A2 (es) 2024-02-05
IL308220A (en) 2024-01-01
CR20230569A (es) 2024-01-22

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