BR112021023635A2 - Novos compostos para inibição de janus quinase 1 - Google Patents

Novos compostos para inibição de janus quinase 1

Info

Publication number
BR112021023635A2
BR112021023635A2 BR112021023635A BR112021023635A BR112021023635A2 BR 112021023635 A2 BR112021023635 A2 BR 112021023635A2 BR 112021023635 A BR112021023635 A BR 112021023635A BR 112021023635 A BR112021023635 A BR 112021023635A BR 112021023635 A2 BR112021023635 A2 BR 112021023635A2
Authority
BR
Brazil
Prior art keywords
janus kinase
novel compounds
compounds
inhibit janus
inhibit
Prior art date
Application number
BR112021023635A
Other languages
English (en)
Inventor
Pandurang Gunjal Amol
Anil Kumar
Himanshu Rai
Mahadev Bandgar
Iswar PATIL Rakesh
Kumar Rai Santosh
Sazid Ali
Reddy Bapuram Srinivasa
Original Assignee
Mankind Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mankind Pharma Ltd filed Critical Mankind Pharma Ltd
Publication of BR112021023635A2 publication Critical patent/BR112021023635A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

novos compostos para inibição de janus quinase 1. um objetivo da invenção é prover compostos como inibidor seletivo de jak1, um processo para preparação dos inibidores, uma composição contendo os compostos e a utilidade dos compostos.
BR112021023635A 2019-05-28 2020-05-26 Novos compostos para inibição de janus quinase 1 BR112021023635A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201911021098 2019-05-28
PCT/IN2020/050471 WO2020240586A1 (en) 2019-05-28 2020-05-26 Novel compounds for inhibition of janus kinase 1

Publications (1)

Publication Number Publication Date
BR112021023635A2 true BR112021023635A2 (pt) 2022-02-01

Family

ID=73553608

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021023635A BR112021023635A2 (pt) 2019-05-28 2020-05-26 Novos compostos para inibição de janus quinase 1

Country Status (10)

Country Link
US (1) US20220235046A1 (pt)
EP (1) EP3976612A4 (pt)
JP (1) JP2022534510A (pt)
CN (1) CN114174294A (pt)
AU (1) AU2020284742A1 (pt)
BR (1) BR112021023635A2 (pt)
CA (1) CA3141571A1 (pt)
MX (1) MX2021014361A (pt)
WO (1) WO2020240586A1 (pt)
ZA (1) ZA202109183B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202245774A (zh) * 2021-02-05 2022-12-01 大陸商上海齊魯製藥研究中心有限公司 嘧啶或吡啶並雜環類腺苷受體抑制劑及其製備方法和用途
KR20240024063A (ko) * 2021-05-06 2024-02-23 엑스사이언티아 에이아이 리미티드 Pkc-세타 조정제
WO2023121992A1 (en) * 2021-12-22 2023-06-29 Icagen, Llc Cyclopropyl compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534796B2 (en) * 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
AR055669A1 (es) * 2005-10-03 2007-08-29 Astrazeneca Ab Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
EA201001224A1 (ru) * 2008-02-04 2011-08-30 Цитокинетикс, Инкорпорейтед Химические соединения, композиции и способы их использования
JP2011526931A (ja) * 2008-07-03 2011-10-20 エグゼリクシス， インコーポレイテッド Ｃｄｋモジュレーター
KR20130076046A (ko) * 2011-12-28 2013-07-08 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
ES2567552T3 (es) * 2012-01-30 2016-04-25 Cephalon, Inc. Imidazo [4,5-b] derivados de piridina como los moduladores ALK y JAK para el tratamiento de trastornos proliferativos
CN106146504B (zh) * 2015-04-17 2018-09-07 上海汇伦生命科技有限公司 一种杂环并咪唑类化合物、其药物组合物及其制备方法和用途
EP3360878B9 (en) * 2015-12-11 2021-05-05 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Azetidine derivative, preparation method therefor, and use thereof
JP6954994B2 (ja) * 2016-08-16 2021-10-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 可逆性ｂｔｋ阻害剤としてのオキソ−イミダゾピリジン及びその使用
GB201717260D0 (en) * 2017-10-20 2017-12-06 Galapagos Nv Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders
CN113508114B (zh) * 2019-02-27 2024-03-26 四川科伦博泰生物医药股份有限公司 以氮杂环丁烷衍生物为活性成分的口服药物组合物、其制备方法及用途

Also Published As

Publication number Publication date
US20220235046A1 (en) 2022-07-28
AU2020284742A1 (en) 2022-02-03
CN114174294A (zh) 2022-03-11
CA3141571A1 (en) 2020-12-03
WO2020240586A1 (en) 2020-12-03
EP3976612A1 (en) 2022-04-06
ZA202109183B (en) 2022-08-31
EP3976612A4 (en) 2023-04-26
MX2021014361A (es) 2022-04-06
TW202110838A (zh) 2021-03-16
JP2022534510A (ja) 2022-08-01

Similar Documents

Publication Publication Date Title
BR112021022457A2 (pt) Inibidores de fgfr e métodos de uso dos mesmos
BR112021023635A2 (pt) Novos compostos para inibição de janus quinase 1
MX2023001917A (es) Inhibidores de la fosfatasa shp2 y metodos para su uso.
EA201990904A1 (ru) 1,3-дизамещенные производные циклобутана или азетидина в качестве ингибиторов гемопоэтической простагландин-d-синтазы
MX2020009234A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas con receptores de interleucina-1 (irak) tipo ii y usos de los mismos.
BR112013001632A2 (pt) composto, composição farmacêutica, método de inibir uma atividade uma jak quinase in vitro, uso de um composto, ou da composição farmacêutica, e, método de fabricar um composto
CL2021001461A1 (es) Moduladores de trex1
TW201613938A (en) Selective inhibitors for protein kinases, a pharmaceutical composition and an use thereof
UY37764A (es) Nuevos compuestos inhibidores de la prostaglandina d sintasa hematopoyética (h-pgds)
AU2018316542A1 (en) Indole derivatives as histone demethylase inhibitors
CO2021001219A2 (es) Benzimidazoles sustituidos como inhibidores de pad4
EA202091400A1 (ru) Производные пиррола в качестве ингибиторов асс
CL2021000843A1 (es) Inhibidores de pde4 que contienen boro
BR112019026577A8 (pt) Compostos aminotiazol como inibidores de proteína quinase
BR112023015210A2 (pt) Inibidores de cdk2 e métodos de uso dos mesmos
CL2022000835A1 (es) Inhibidor de diacilglicerol aciltransferasa 2
BR112022010054A2 (pt) Compostos heterocíclicos como inibidores de delta-5 dessaturase e métodos de uso
CL2022001404A1 (es) Composición para la inhibición de la producción de hmf que comprende disacárido de alulosa
WO2018166993A3 (en) PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
PH12021550258A1 (en) Cdk8/19 inhibitors
BR112016026329A8 (pt) composição, artigo, métodos para estabilizar um material orgânico e um polímero, e, película
MX2020007342A (es) Compuestos de sililetinilo hetarilo como inhibidores de la nitrificacion.
EA202090888A1 (ru) Соединение, обладающее активностью по ингибированию erk киназы, и его применение
BR112022004221A2 (pt) Tratamento de hidradenite com inibidores de jak
UY38899A (es) Inhibidor de diacilglicerol aciltransferasa 2