BR112021021706A2 - Processo para preparar inibidores de xpo1 e intermediários para uso na preparação de inibidores de xp01 - Google Patents
Processo para preparar inibidores de xpo1 e intermediários para uso na preparação de inibidores de xp01Info
- Publication number
- BR112021021706A2 BR112021021706A2 BR112021021706A BR112021021706A BR112021021706A2 BR 112021021706 A2 BR112021021706 A2 BR 112021021706A2 BR 112021021706 A BR112021021706 A BR 112021021706A BR 112021021706 A BR112021021706 A BR 112021021706A BR 112021021706 A2 BR112021021706 A2 BR 112021021706A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- inhibitors
- structural formula
- intermediates
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title abstract 3
- 101150094313 XPO1 gene Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- DEVSOMFAQLZNKR-RJRFIUFISA-N (z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-n'-pyrazin-2-ylprop-2-enehydrazide Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C2=NN(\C=C/C(=O)NNC=3N=CC=NC=3)C=N2)=C1 DEVSOMFAQLZNKR-RJRFIUFISA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- YPMUIQDGERASRJ-UPHRSURJSA-N (z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoic acid Chemical compound OC(=O)\C=C/N1C=NC(C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)=N1 YPMUIQDGERASRJ-UPHRSURJSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229950010613 selinexor Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962841649P | 2019-05-01 | 2019-05-01 | |
| PCT/US2020/031124 WO2020223678A1 (en) | 2019-05-01 | 2020-05-01 | Process for preparing xpo1 inhibitors and intermediates for use in the preparation of xp01 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021021706A2 true BR112021021706A2 (pt) | 2022-04-19 |
Family
ID=70802955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021021706A BR112021021706A2 (pt) | 2019-05-01 | 2020-05-01 | Processo para preparar inibidores de xpo1 e intermediários para uso na preparação de inibidores de xp01 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12479806B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3962898A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7630444B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20220004142A (cg-RX-API-DMAC7.html) |
| CN (1) | CN114040909B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2020266170B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112021021706A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3135712A1 (cg-RX-API-DMAC7.html) |
| CR (1) | CR20210590A (cg-RX-API-DMAC7.html) |
| IL (1) | IL287673B1 (cg-RX-API-DMAC7.html) |
| MA (1) | MA55808A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2021013211A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11202111993SA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2020223678A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114040909B (zh) | 2019-05-01 | 2025-06-03 | 卡尔约药物治疗公司 | 用于制备xpo1抑制剂以及用于制备xp01抑制剂的中间体的方法 |
| JP2021048976A (ja) * | 2019-09-24 | 2021-04-01 | 株式会社ユニバーサルエンターテインメント | 遊技機 |
| CN112679477B (zh) * | 2020-12-17 | 2021-10-26 | 佛山奕安赛医药科技有限公司 | 塞利尼索及其中间体的制备方法 |
| CN116514773B (zh) * | 2023-04-24 | 2024-12-03 | 重庆汉佩生物科技有限公司 | 一种Verdinexor(KPT-335)及其盐酸盐的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2542089B1 (en) | 2010-03-05 | 2017-01-18 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP2665362B1 (en) | 2011-01-17 | 2016-03-30 | Karyopharm Therapeutics, Inc. | Olefin containing nuclear transport modulators and uses thereof |
| EP4234545A3 (en) | 2011-07-29 | 2023-09-06 | Karyopharm Therapeutics Inc. | Hydrazide containing nuclear transport modulators and uses thereof |
| JP6006794B2 (ja) | 2011-07-29 | 2016-10-12 | カリオファーム セラピューティクス，インコーポレイテッド | 核内輸送調節因子およびその使用 |
| WO2013170068A2 (en) * | 2012-05-09 | 2013-11-14 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP2968278B8 (en) | 2013-03-15 | 2019-05-22 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| WO2014205393A1 (en) | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| ME03421B (me) | 2013-06-21 | 2020-01-20 | Karyopharm Therapeutics Inc | 1,2,4-triazoli kao modulatori nuklearnog transporta i njihova upotreba |
| KR102608259B1 (ko) | 2014-08-15 | 2023-11-29 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | 셀리넥소의 다형태 |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| WO2017118940A1 (en) * | 2016-01-08 | 2017-07-13 | Dr. Reddy's Laboratories Limited | Solid forms of selinexor and process for their preparation |
| EP3565813A1 (en) * | 2017-01-05 | 2019-11-13 | Watson Laboratories, Inc. | Novel crystalline forms of selinexor and process for their preparation |
| CN114040909B (zh) | 2019-05-01 | 2025-06-03 | 卡尔约药物治疗公司 | 用于制备xpo1抑制剂以及用于制备xp01抑制剂的中间体的方法 |
-
2020
- 2020-05-01 CN CN202080048243.6A patent/CN114040909B/zh active Active
- 2020-05-01 AU AU2020266170A patent/AU2020266170B2/en active Active
- 2020-05-01 SG SG11202111993SA patent/SG11202111993SA/en unknown
- 2020-05-01 BR BR112021021706A patent/BR112021021706A2/pt unknown
- 2020-05-01 MX MX2021013211A patent/MX2021013211A/es unknown
- 2020-05-01 WO PCT/US2020/031124 patent/WO2020223678A1/en not_active Ceased
- 2020-05-01 CA CA3135712A patent/CA3135712A1/en active Pending
- 2020-05-01 MA MA055808A patent/MA55808A/fr unknown
- 2020-05-01 US US17/607,670 patent/US12479806B2/en active Active
- 2020-05-01 CR CR20210590A patent/CR20210590A/es unknown
- 2020-05-01 KR KR1020217038842A patent/KR20220004142A/ko active Pending
- 2020-05-01 JP JP2021564434A patent/JP7630444B2/ja active Active
- 2020-05-01 EP EP20727786.4A patent/EP3962898A1/en active Pending
-
2021
- 2021-10-28 IL IL287673A patent/IL287673B1/en unknown
-
2025
- 2025-02-04 JP JP2025016855A patent/JP7850834B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020266170A1 (en) | 2021-11-25 |
| US20220242832A1 (en) | 2022-08-04 |
| CR20210590A (es) | 2022-03-11 |
| JP2025072490A (ja) | 2025-05-09 |
| JP2022531576A (ja) | 2022-07-07 |
| JP7850834B2 (ja) | 2026-04-23 |
| CA3135712A1 (en) | 2020-11-05 |
| WO2020223678A1 (en) | 2020-11-05 |
| US12479806B2 (en) | 2025-11-25 |
| MX2021013211A (es) | 2022-03-11 |
| SG11202111993SA (en) | 2021-11-29 |
| IL287673B1 (en) | 2026-01-01 |
| EP3962898A1 (en) | 2022-03-09 |
| MA55808A (fr) | 2022-03-09 |
| JP7630444B2 (ja) | 2025-02-17 |
| CN114040909A (zh) | 2022-02-11 |
| IL287673A (en) | 2021-12-01 |
| KR20220004142A (ko) | 2022-01-11 |
| AU2020266170B2 (en) | 2026-02-26 |
| CN114040909B (zh) | 2025-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |