AR061310A1 - Procesos para preparar compuestos intermediarios utiles para la preparacion de cinacalcet - Google Patents

Procesos para preparar compuestos intermediarios utiles para la preparacion de cinacalcet

Info

Publication number
AR061310A1
AR061310A1 ARP070102513A ARP070102513A AR061310A1 AR 061310 A1 AR061310 A1 AR 061310A1 AR P070102513 A ARP070102513 A AR P070102513A AR P070102513 A ARP070102513 A AR P070102513A AR 061310 A1 AR061310 A1 AR 061310A1
Authority
AR
Argentina
Prior art keywords
cinacalcet
preparation
processes
intermediate compounds
useful intermediate
Prior art date
Application number
ARP070102513A
Other languages
English (en)
Inventor
Tibor Szekeres
Jozsef Repasi
Andres Szabo
Bernardino Mangion
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR061310A1 publication Critical patent/AR061310A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un proceso mejorado para preparar compuestos (por ejemplo, 3-(3-trifluorometilfenil)propanal (Compuesto III, más adelante)), que son intermediarios clave para la síntesis de cinacalcet, sus sales y/o solvatos del mismo, así como el uso de dichos compuestos preparados por tal proceso para la preparacion de cinacalcet y/o sus sales o solvatos.
ARP070102513A 2006-06-08 2007-06-08 Procesos para preparar compuestos intermediarios utiles para la preparacion de cinacalcet AR061310A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81178606P 2006-06-08 2006-06-08

Publications (1)

Publication Number Publication Date
AR061310A1 true AR061310A1 (es) 2008-08-20

Family

ID=39200909

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102513A AR061310A1 (es) 2006-06-08 2007-06-08 Procesos para preparar compuestos intermediarios utiles para la preparacion de cinacalcet

Country Status (8)

Country Link
US (1) US20100267988A1 (es)
EP (1) EP2041056A2 (es)
JP (1) JP2009539823A (es)
CN (1) CN101500976A (es)
AR (1) AR061310A1 (es)
CA (1) CA2659153A1 (es)
IL (1) IL195757A0 (es)
WO (1) WO2008035212A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2376424A1 (en) 2008-12-08 2011-10-19 Actavis Group PTC EHF Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
CN102548955B (zh) 2009-09-10 2014-06-04 Zach系统股份公司 用于制备西那卡塞特的方法
CN102060679B (zh) * 2009-11-18 2014-11-19 中国中化股份有限公司 一种芳基丙醛衍生物的制备方法
CN102060675A (zh) * 2009-11-18 2011-05-18 中国中化股份有限公司 3-芳基-1-丙烯醇醚及其制备方法
IT1396623B1 (it) * 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
EP2593422B1 (en) 2010-07-16 2020-01-15 Hetero Research Foundation Process for cinacalcet hydrochloride
CZ2011770A3 (cs) 2011-11-25 2013-01-16 Zentiva, K.S. Zpusob výroby Cinacalcetu
WO2014016847A1 (en) 2012-07-25 2014-01-30 Tyche Industries Limited A process for the preparation of cinacalcet hydrochloride and its intermediate
CN103664577B (zh) * 2012-09-06 2015-04-08 北京万生药业有限责任公司 一种西那卡塞中间体的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN113121388B (zh) * 2021-03-29 2021-11-12 西华大学 西那卡塞中间体以及盐酸西那卡塞的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77905A (en) * 1985-02-18 1989-10-31 Wellcome Found Dieneamides,their preparation and their use as insecticides and acaricides

Also Published As

Publication number Publication date
JP2009539823A (ja) 2009-11-19
CA2659153A1 (en) 2008-03-27
EP2041056A2 (en) 2009-04-01
US20100267988A1 (en) 2010-10-21
IL195757A0 (en) 2009-09-01
WO2008035212A3 (en) 2008-08-21
CN101500976A (zh) 2009-08-05
WO2008035212A2 (en) 2008-03-27

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