BR112021021516A2 - Derivado de pirimidina substituído heterocíclico que exibe efeito inibidor do crescimento de células cancerígenas e composição farmacêutica contendo o mesmo - Google Patents
Derivado de pirimidina substituído heterocíclico que exibe efeito inibidor do crescimento de células cancerígenas e composição farmacêutica contendo o mesmoInfo
- Publication number
- BR112021021516A2 BR112021021516A2 BR112021021516A BR112021021516A BR112021021516A2 BR 112021021516 A2 BR112021021516 A2 BR 112021021516A2 BR 112021021516 A BR112021021516 A BR 112021021516A BR 112021021516 A BR112021021516 A BR 112021021516A BR 112021021516 A2 BR112021021516 A2 BR 112021021516A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- same
- inhibitory effect
- cell growth
- composition containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
derivado de pirimidina substituído heterocíclico que exibe efeito inibidor do crescimento de células cancerígenas e composição farmacêutica contendo o mesmo. a presente invenção refere-se a um novo composto representado pela fórmula química 1 ou um sal do mesmo e uma composição farmacêutica para o tratamento de câncer de pulmão contendo o mesmo. um derivado de composto pirimidínio representado pela fórmula química 1 inibe eficazmente o crescimento de células cancerígenas com uma mutação do alk e uma mutação do egfr, dessa forma, sendo eficazmente usável no tratamento de câncer de pulmão.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020190137489A KR102168179B1 (ko) | 2019-10-31 | 2019-10-31 | 암세포 성장 억제 효과를 나타내는 신규한 헤테로 고리 치환 피리미딘 유도체 및 그를 포함하는 약제학적 조성물 |
PCT/KR2020/013779 WO2021085888A1 (ko) | 2019-10-31 | 2020-10-08 | 암세포 성장 억제 효과를 나타내는 신규한 헤테로 고리 치환 피리미딘 유도체 및 그를 포함하는 약제학적 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021021516A2 true BR112021021516A2 (pt) | 2022-05-24 |
Family
ID=73025459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021021516A BR112021021516A2 (pt) | 2019-10-31 | 2020-10-08 | Derivado de pirimidina substituído heterocíclico que exibe efeito inibidor do crescimento de células cancerígenas e composição farmacêutica contendo o mesmo |
Country Status (9)
Country | Link |
---|---|
US (1) | US20220204492A1 (pt) |
EP (1) | EP4053121A4 (pt) |
JP (1) | JP2023500755A (pt) |
KR (1) | KR102168179B1 (pt) |
CN (1) | CN113840823A (pt) |
AU (1) | AU2020374269A1 (pt) |
BR (1) | BR112021021516A2 (pt) |
CA (1) | CA3132640A1 (pt) |
WO (1) | WO2021085888A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023518609A (ja) * | 2020-03-23 | 2023-05-02 | チールー ファーマシューティカル カンパニー、リミテッド | 新規アミノピリミジン系egfr阻害剤 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
NO2300013T3 (pt) | 2008-05-21 | 2018-02-03 | ||
MX360970B (es) * | 2008-06-27 | 2018-11-23 | Avila Therapeutics Inc | Compuestos de heteroarilo y usos de los mismos. |
US10106507B2 (en) * | 2014-08-03 | 2018-10-23 | H. Lee Moffitt Cancer Center and Research Insitute, Inc. | Potent dual BRD4-kinase inhibitors as cancer therapeutics |
CN106883213B (zh) * | 2015-12-15 | 2021-04-20 | 合肥中科普瑞昇生物医药科技有限公司 | 一种egfr和alk激酶的双重抑制剂 |
US20210267997A1 (en) * | 2017-02-24 | 2021-09-02 | Daegu-Gyeongbuk Medical Innovation Foundation | Pharmaceutical Composition Comprising Compound Capable of Penetrating Blood-Brain Barrier as Effective Ingredient for Preventing or Treating Brain Cancer |
KR101992621B1 (ko) * | 2017-12-07 | 2019-09-27 | 주식회사 온코빅스 | 암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물 |
KR20190114910A (ko) * | 2018-03-30 | 2019-10-10 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 설폰아마이드 유도체 |
KR102054943B1 (ko) | 2018-06-01 | 2019-12-12 | 주식회사 와이드 | 사출성형기용 노즐 히터 |
-
2019
- 2019-10-31 KR KR1020190137489A patent/KR102168179B1/ko active IP Right Grant
-
2020
- 2020-10-08 AU AU2020374269A patent/AU2020374269A1/en active Pending
- 2020-10-08 WO PCT/KR2020/013779 patent/WO2021085888A1/ko unknown
- 2020-10-08 EP EP20880791.7A patent/EP4053121A4/en active Pending
- 2020-10-08 US US17/601,790 patent/US20220204492A1/en active Pending
- 2020-10-08 CA CA3132640A patent/CA3132640A1/en active Pending
- 2020-10-08 BR BR112021021516A patent/BR112021021516A2/pt unknown
- 2020-10-08 JP JP2021562875A patent/JP2023500755A/ja active Pending
- 2020-10-08 CN CN202080034942.5A patent/CN113840823A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220204492A1 (en) | 2022-06-30 |
EP4053121A1 (en) | 2022-09-07 |
WO2021085888A1 (ko) | 2021-05-06 |
KR102168179B1 (ko) | 2020-10-20 |
JP2023500755A (ja) | 2023-01-11 |
CA3132640A1 (en) | 2021-05-06 |
CN113840823A (zh) | 2021-12-24 |
EP4053121A4 (en) | 2023-10-25 |
AU2020374269A1 (en) | 2021-12-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020014098A (es) | Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington. | |
BR112022004248A2 (pt) | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, método para inibir a atividade de prmt5 em uma célula, e, método para o tratamento de câncer | |
NZ763766A (en) | Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators | |
MX2022009998A (es) | Formas cristalinas de la n-(4-(4-(ciclopropilmetil)piperazin-1- carbonil)fenil)quinolin-8-sulfonamida. | |
UY35377A (es) | Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y métodos de uso | |
BR112019007108A2 (pt) | misturas herbicidas | |
NO20092725L (no) | Quinazoliner for PDK1 inhibering | |
BR112016028642A2 (pt) | composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo. | |
TN2010000293A1 (en) | Thiazole derivatives used as pi 3 kinase inhibitors | |
BR112016029846A2 (pt) | ?composto, composição farmacêutica, métodos para o método para tratamento de um humano, para inibição da atividade de um polipeptídio de fosfatidilinositol 3-quinase e inibição excessiva ou reações imunes destrutivas ou crescimento ou uma proliferação de células de câncer, kit, e, uso de um composto, um sal farmaceuticamente aceitável, isômero, ou uma mistura do mesmo? | |
UA116768C2 (uk) | Дизаміщені бензотієнілпіролотриазини та їх застосування як інгібіторів кінази рфрф | |
BR112014026801A2 (pt) | 5-[[4-[[morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazina-2-carbonitrila e usos terapêuticos do mesmo | |
BR112021006620A2 (pt) | compostos de aminoácidos e métodos de uso | |
BR112014005226A2 (pt) | derivados de benzonitrila como inibidores de cinase | |
BR112016022069A2 (pt) | Composto, composição farmacêutica, e, uso de um composto | |
BR112016028876A2 (pt) | composto, composição farmacêutica, método para tratar uma doença ou condição em um ser humano, kit, e, uso de um composto, um sal, isômero ou uma mistura farmaceuticamente aceitável dos mesmos. | |
SG10201806965XA (en) | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer | |
BR112017012197A2 (pt) | composto, composição herbicida, mistura herbicida e método para controlar o crescimento de vegetação indesejada | |
BR112015017331A8 (pt) | compostos de fórmula i, forma cristalina, uso dos compostos, combinação, composição e método de seleção para tratamento de câncer | |
BR112016028814A2 (pt) | ?composição farmacêutica, métodos de tratamento de uma doença ou condição, de inibição de reações imunitárias ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, composto, um sal, um isômero, ou uma mistura farmaceuticamente aceitável do mesmo, e, uso de um composto, de um sal, de um isômero, ou de uma mistura farmaceuticamente aceitável do mesmo? | |
EA202091803A1 (ru) | Производные триазолопиримидина для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat) | |
BR112019003710A2 (pt) | inibidor de pde7, composto, composição farmacêutica, uso de um inibidor de pde7 ou de um composto, e, método para tratar ou prevenir uma doença que é melhorada pela inibição de pde7. | |
BR112019003897A2 (pt) | aminopirimidinas como inibidores de alk | |
BR112013029999A2 (pt) | derivados de tiazol | |
BR112018016133A2 (pt) | aglutinantes de max como moduladores de myc e usos dos mesmos |