BR112021019446A2 - Inibidores de tirosina quinase fgfr para o tratamento de carcinoma urotelial - Google Patents
Inibidores de tirosina quinase fgfr para o tratamento de carcinoma urotelialInfo
- Publication number
- BR112021019446A2 BR112021019446A2 BR112021019446A BR112021019446A BR112021019446A2 BR 112021019446 A2 BR112021019446 A2 BR 112021019446A2 BR 112021019446 A BR112021019446 A BR 112021019446A BR 112021019446 A BR112021019446 A BR 112021019446A BR 112021019446 A2 BR112021019446 A2 BR 112021019446A2
- Authority
- BR
- Brazil
- Prior art keywords
- urothelial carcinoma
- fgfr
- treatment
- tyrosine kinase
- kinase inhibitors
- Prior art date
Links
- 206010044412 transitional cell carcinoma Diseases 0.000 title abstract 4
- 208000023747 urothelial carcinoma Diseases 0.000 title abstract 4
- 108091008794 FGF receptors Proteins 0.000 title abstract 3
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title abstract 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title abstract 2
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 title 1
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 abstract 2
- 229940125829 fibroblast growth factor receptor inhibitor Drugs 0.000 abstract 2
- 230000004077 genetic alteration Effects 0.000 abstract 2
- 231100000118 genetic alteration Toxicity 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
Abstract
inibidores de tirosina quinase fgfr para o tratamento de carcinoma urotelial. a presente invenção refere-se a métodos de tratamento de carcinoma urotelial em um paciente, compreendendo a avaliação de uma amostra biológica do paciente quanto à presença de pelo menos duas alterações genéticas do receptor do fator de crescimento de fibroblastos (fgfr) e o tratamento do paciente com um inibidor de fgfr. também são aqui descritos métodos de tratamento de carcinoma urotelial em um paciente com pelo menos duas alterações genéticas do receptor do fator de crescimento de fibroblastos (fgfr), compreendendo a administração de um inibidor de fgfr.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19166428 | 2019-03-29 | ||
EP19188971 | 2019-07-30 | ||
PCT/US2020/025166 WO2020205493A1 (en) | 2019-03-29 | 2020-03-27 | Fgfr tyrosine kinase inhibitors for the treatment of urothelial carcinoma |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021019446A2 true BR112021019446A2 (pt) | 2021-11-30 |
Family
ID=70296138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021019446A BR112021019446A2 (pt) | 2019-03-29 | 2020-03-27 | Inibidores de tirosina quinase fgfr para o tratamento de carcinoma urotelial |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220054484A1 (pt) |
EP (1) | EP3946341A1 (pt) |
JP (1) | JP2022527189A (pt) |
KR (1) | KR20210145211A (pt) |
CN (1) | CN113645974A (pt) |
AU (1) | AU2020253827A1 (pt) |
BR (1) | BR112021019446A2 (pt) |
CA (1) | CA3130460A1 (pt) |
IL (1) | IL286729A (pt) |
JO (1) | JOP20210266A1 (pt) |
MA (1) | MA55522A (pt) |
MX (1) | MX2021011926A (pt) |
SG (1) | SG11202109902SA (pt) |
WO (1) | WO2020205493A1 (pt) |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
WO1998004689A1 (en) | 1995-07-31 | 1998-02-05 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
RU2425041C2 (ru) | 2005-05-23 | 2011-07-27 | Новартис Аг | Кристаллические и другие формы солей, образованных из молочной кислоты и 4-амино-5-фтор-3-[6-(4-метилпиперазин-1-ил)-1н-бензимидазол-2-ил]-1н-хинолин-2-она |
US8163923B2 (en) | 2007-03-14 | 2012-04-24 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
CN113957146A (zh) | 2014-09-26 | 2022-01-21 | 詹森药业有限公司 | 使用fgfr突变基因组鉴定将对用fgfr抑制剂进行治疗有反应的癌症患者 |
EP3365335B1 (en) * | 2015-10-23 | 2024-02-14 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
JOP20190190A1 (ar) * | 2017-02-06 | 2019-08-04 | Janssen Pharmaceutica Nv | معالجة سرطان |
JOP20190280A1 (ar) * | 2017-06-02 | 2019-12-02 | Janssen Pharmaceutica Nv | مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية |
-
2020
- 2020-03-27 US US17/599,729 patent/US20220054484A1/en active Pending
- 2020-03-27 WO PCT/US2020/025166 patent/WO2020205493A1/en active Application Filing
- 2020-03-27 JP JP2021557924A patent/JP2022527189A/ja active Pending
- 2020-03-27 BR BR112021019446A patent/BR112021019446A2/pt unknown
- 2020-03-27 MA MA055522A patent/MA55522A/fr unknown
- 2020-03-27 SG SG11202109902S patent/SG11202109902SA/en unknown
- 2020-03-27 KR KR1020217034721A patent/KR20210145211A/ko active Search and Examination
- 2020-03-27 AU AU2020253827A patent/AU2020253827A1/en active Pending
- 2020-03-27 CN CN202080025860.4A patent/CN113645974A/zh active Pending
- 2020-03-27 EP EP20720283.9A patent/EP3946341A1/en active Pending
- 2020-03-27 CA CA3130460A patent/CA3130460A1/en active Pending
- 2020-03-27 MX MX2021011926A patent/MX2021011926A/es unknown
- 2020-03-27 JO JOP/2021/0266A patent/JOP20210266A1/ar unknown
-
2021
- 2021-09-26 IL IL286729A patent/IL286729A/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG11202109902SA (en) | 2021-10-28 |
AU2020253827A1 (en) | 2021-09-30 |
KR20210145211A (ko) | 2021-12-01 |
WO2020205493A1 (en) | 2020-10-08 |
JOP20210266A1 (ar) | 2023-01-30 |
JP2022527189A (ja) | 2022-05-31 |
CA3130460A1 (en) | 2020-10-08 |
MA55522A (fr) | 2022-02-09 |
IL286729A (en) | 2021-10-31 |
MX2021011926A (es) | 2021-11-03 |
EP3946341A1 (en) | 2022-02-09 |
CN113645974A (zh) | 2021-11-12 |
US20220054484A1 (en) | 2022-02-24 |
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