BR112021018205A2 - Pequenos agentes bloqueadores de liberação. - Google Patents
Pequenos agentes bloqueadores de liberação.Info
- Publication number
- BR112021018205A2 BR112021018205A2 BR112021018205A BR112021018205A BR112021018205A2 BR 112021018205 A2 BR112021018205 A2 BR 112021018205A2 BR 112021018205 A BR112021018205 A BR 112021018205A BR 112021018205 A BR112021018205 A BR 112021018205A BR 112021018205 A2 BR112021018205 A2 BR 112021018205A2
- Authority
- BR
- Brazil
- Prior art keywords
- blocking agents
- small release
- release blocking
- agents
- immune receptor
- Prior art date
Links
- 239000002981 blocking agent Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102000027596 immune receptors Human genes 0.000 abstract 2
- 108091008915 immune receptors Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
pequenos agentes bloqueadores de liberação. são fornecidos agentes com menos de 100 quilodaltons que se ligam a um receptor imunológico membranal em uma superfície de uma célula e inibem a clivagem proteolítica do receptor imunológico. métodos de tratamento de câncer e melhoria da imunoterapia compreendendo a administração dos agentes também são fornecidos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962818351P | 2019-03-14 | 2019-03-14 | |
US201962942240P | 2019-12-02 | 2019-12-02 | |
US201962954802P | 2019-12-30 | 2019-12-30 | |
PCT/IL2020/050297 WO2020183473A1 (en) | 2019-03-14 | 2020-03-12 | Small shedding blocking agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021018205A2 true BR112021018205A2 (pt) | 2021-12-28 |
Family
ID=70334001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021018205A BR112021018205A2 (pt) | 2019-03-14 | 2020-03-12 | Pequenos agentes bloqueadores de liberação. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220169732A1 (pt) |
EP (1) | EP3938397A1 (pt) |
JP (1) | JP2022525407A (pt) |
KR (1) | KR20210141544A (pt) |
CN (1) | CN113710704A (pt) |
AU (1) | AU2020234111A1 (pt) |
BR (1) | BR112021018205A2 (pt) |
CA (1) | CA3130351A1 (pt) |
IL (1) | IL286377A (pt) |
SG (1) | SG11202110032TA (pt) |
WO (1) | WO2020183473A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021235569A1 (en) * | 2020-03-12 | 2022-10-06 | Biond Biologics Ltd. | Shedding blocking agents with increased stability |
AU2022341016A1 (en) * | 2021-09-06 | 2024-04-18 | Biond Biologics Ltd. | Cd28 shedding blocking agents |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
CN100509849C (zh) * | 2005-04-07 | 2009-07-08 | 苏州大学 | 可溶性人cd28分子检测试剂盒及其应用 |
WO2010009391A1 (en) * | 2008-07-18 | 2010-01-21 | Bristol-Myers Squibb Company | Compositions monovalent for cd28 binding and methods of use |
CN112074539A (zh) * | 2018-03-15 | 2020-12-11 | 比昂生物制剂公司 | 降低可溶性免疫受体cd28的方法和组合物 |
-
2020
- 2020-03-12 US US17/439,065 patent/US20220169732A1/en active Pending
- 2020-03-12 WO PCT/IL2020/050297 patent/WO2020183473A1/en unknown
- 2020-03-12 CA CA3130351A patent/CA3130351A1/en active Pending
- 2020-03-12 EP EP20720532.9A patent/EP3938397A1/en active Pending
- 2020-03-12 CN CN202080028967.4A patent/CN113710704A/zh active Pending
- 2020-03-12 SG SG11202110032TA patent/SG11202110032TA/en unknown
- 2020-03-12 KR KR1020217032763A patent/KR20210141544A/ko unknown
- 2020-03-12 JP JP2021555537A patent/JP2022525407A/ja active Pending
- 2020-03-12 AU AU2020234111A patent/AU2020234111A1/en active Pending
- 2020-03-12 BR BR112021018205A patent/BR112021018205A2/pt not_active Application Discontinuation
-
2021
- 2021-09-13 IL IL286377A patent/IL286377A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20220169732A1 (en) | 2022-06-02 |
JP2022525407A (ja) | 2022-05-13 |
KR20210141544A (ko) | 2021-11-23 |
WO2020183473A1 (en) | 2020-09-17 |
CN113710704A (zh) | 2021-11-26 |
AU2020234111A1 (en) | 2021-10-14 |
EP3938397A1 (en) | 2022-01-19 |
IL286377A (en) | 2021-10-31 |
SG11202110032TA (en) | 2021-10-28 |
CA3130351A1 (en) | 2020-09-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |