BR112021017659A2 - Células hospedeiras não vegetais produtoras de alcaloide de tropano (ta), e métodos de preparação e uso das mesmas - Google Patents

Células hospedeiras não vegetais produtoras de alcaloide de tropano (ta), e métodos de preparação e uso das mesmas

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Publication number
BR112021017659A2
BR112021017659A2 BR112021017659A BR112021017659A BR112021017659A2 BR 112021017659 A2 BR112021017659 A2 BR 112021017659A2 BR 112021017659 A BR112021017659 A BR 112021017659A BR 112021017659 A BR112021017659 A BR 112021017659A BR 112021017659 A2 BR112021017659 A2 BR 112021017659A2
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Brazil
Prior art keywords
tropane alkaloid
preparation
methods
host cells
plant host
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BR112021017659A
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English (en)
Inventor
D Smolke Christina
Prashanth Srinivasan
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Univ Leland Stanford Junior
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Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of BR112021017659A2 publication Critical patent/BR112021017659A2/pt

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    • C12Y401/00—Carbon-carbon lyases (4.1)
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    • C12Y403/01025—Phenylalanine-tyrosine ammonia-lyase (4.3.1.25)

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Abstract

células hospedeiras não vegetais produtoras de alcaloide de tropano (ta), e métodos de preparação e uso das mesmas. é fornecida aqui, entre outras coisas, uma célula não vegetal modificada que produz um produto alcaloide de tropano, um precursor de um produto alcaloide de tropano, ou um derivado de um produto alcaloide de tropano. é também descrito um método para produção de um alcaloide de tropano, um precursor de um produto alcaloide de tropano, ou um derivado de um produto alcaloide de tropano que faz uso da célula.
BR112021017659A 2019-03-08 2020-03-06 Células hospedeiras não vegetais produtoras de alcaloide de tropano (ta), e métodos de preparação e uso das mesmas BR112021017659A2 (pt)

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PCT/US2020/021577 WO2020185626A1 (en) 2019-03-08 2020-03-06 Tropane alkaloid (ta) producing non-plant host cells, and methods of making and using the same

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US11124814B2 (en) 2013-11-04 2021-09-21 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
EP4253525A3 (en) 2015-05-08 2023-10-18 The Board of Trustees of the Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
CN110452916B (zh) * 2019-09-03 2020-11-10 西南大学 莨菪醛还原酶及其应用
US20240191267A1 (en) * 2021-03-25 2024-06-13 The Board Of Trustees Of The Leland Stanford Junior University Tropane Alkaloid Transporters and Methods of Making Tropane Alkaloids Using the Same
CN113307884B (zh) * 2021-05-25 2022-04-29 西南大学 托品酮生物合成融合蛋白及其应用和方法
CN113308447B (zh) * 2021-05-31 2022-09-30 西南大学 拟南芥ugt74f2在催化苯乳酸合成苯乳酰葡萄糖中的应用
CN116790536B (zh) * 2022-07-13 2024-06-04 中国科学院昆明植物研究所 来自古柯的芽子酮甲基转移酶EnEMT1和EnEMT2及其基因和应用
CN115466255B (zh) * 2022-11-01 2023-03-10 北京世纪迈劲生物科技有限公司 一种托品醇及其合成方法
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US11124814B2 (en) * 2013-11-04 2021-09-21 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
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US20220170026A1 (en) 2022-06-02
EP3934765A1 (en) 2022-01-12
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