BR112021017603A2 - Vírus adenoassociado (aav) mutante tendo propriedade de direcionamento para o cérebro - Google Patents
Vírus adenoassociado (aav) mutante tendo propriedade de direcionamento para o cérebroInfo
- Publication number
- BR112021017603A2 BR112021017603A2 BR112021017603A BR112021017603A BR112021017603A2 BR 112021017603 A2 BR112021017603 A2 BR 112021017603A2 BR 112021017603 A BR112021017603 A BR 112021017603A BR 112021017603 A BR112021017603 A BR 112021017603A BR 112021017603 A2 BR112021017603 A2 BR 112021017603A2
- Authority
- BR
- Brazil
- Prior art keywords
- aav
- associated virus
- brain
- amino acid
- adeno
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019082417 | 2019-04-24 | ||
| PCT/JP2020/017495 WO2020218419A1 (ja) | 2019-04-24 | 2020-04-23 | 脳に指向性を有するａａｖ変異体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021017603A2 true BR112021017603A2 (pt) | 2021-11-16 |
Family
ID=72942142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021017603A BR112021017603A2 (pt) | 2019-04-24 | 2020-04-23 | Vírus adenoassociado (aav) mutante tendo propriedade de direcionamento para o cérebro |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12421526B2 (https=) |
| EP (1) | EP3960755A4 (https=) |
| JP (1) | JP7524166B2 (https=) |
| KR (1) | KR102917057B1 (https=) |
| CN (1) | CN113748122B (https=) |
| AU (1) | AU2020263757B2 (https=) |
| BR (1) | BR112021017603A2 (https=) |
| CA (1) | CA3132447A1 (https=) |
| IL (1) | IL286212A (https=) |
| WO (1) | WO2020218419A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3575398A4 (en) * | 2017-01-30 | 2020-11-11 | Nippon Medical School Foundation | ADENO-ASSOCIATED VIRUS (AAV) CAPSIDE PROTEIN MUTANT |
| CN115960177B (zh) * | 2022-10-09 | 2023-07-07 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN116789739B (zh) * | 2022-12-08 | 2024-01-26 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN116284262B (zh) * | 2023-02-13 | 2026-03-17 | 和元生物技术（上海）股份有限公司 | 高效感染ht-22细胞的腺相关病毒突变体 |
| CN116693633B (zh) * | 2023-02-21 | 2023-12-22 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN121569040A (zh) | 2023-07-27 | 2026-02-24 | 宝生物工程株式会社 | 脑趋向性aav突变体 |
| CN121816425A (zh) * | 2023-09-11 | 2026-04-07 | 学校法人顺天堂 | 能够感染内耳的aav变体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| EP2176283B1 (en) | 2007-07-14 | 2016-11-02 | University of Iowa Research Foundation | Methods and compositions for treating brain diseases |
| WO2010114143A1 (ja) * | 2009-03-30 | 2010-10-07 | 国立大学法人岡山大学 | 特異的プロモーターの活性を上昇させるシステム及び該システムを保持したベクター |
| CN105755044A (zh) | 2011-04-22 | 2016-07-13 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体及其使用方法 |
| WO2013014764A1 (ja) | 2011-07-27 | 2013-01-31 | 三菱電機株式会社 | 通信システム、通信装置および通信方法 |
| US9938541B2 (en) | 2012-12-25 | 2018-04-10 | Takara Bio Inc. | AAV variant |
| HK1222673A1 (zh) | 2013-07-12 | 2017-07-07 | The Children's Hospital Of Philadelphia | Aav载体和用於抗aav(腺相关病毒)中和抗体的检测 |
| GB201403684D0 (en) | 2014-03-03 | 2014-04-16 | King S College London | Vector |
| CA2942289C (en) * | 2014-03-10 | 2024-05-21 | Uniqure Ip B.V. | Further improved aav vectors produced in insect cells |
| DE102014207498A1 (de) | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| US11364308B2 (en) * | 2016-05-13 | 2022-06-21 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and methods of use thereof |
| EP3890017B1 (en) | 2018-12-04 | 2025-08-13 | Ningbo Sunny Opotech Co., Ltd. | Photosensitive assembly, photographic module, manufacturing method for photographic assembly, and electronic device |
-
2020
- 2020-04-23 KR KR1020217035927A patent/KR102917057B1/ko active Active
- 2020-04-23 CA CA3132447A patent/CA3132447A1/en active Pending
- 2020-04-23 AU AU2020263757A patent/AU2020263757B2/en active Active
- 2020-04-23 JP JP2021516202A patent/JP7524166B2/ja active Active
- 2020-04-23 BR BR112021017603A patent/BR112021017603A2/pt unknown
- 2020-04-23 WO PCT/JP2020/017495 patent/WO2020218419A1/ja not_active Ceased
- 2020-04-23 CN CN202080030827.0A patent/CN113748122B/zh active Active
- 2020-04-23 EP EP20795029.6A patent/EP3960755A4/en active Pending
- 2020-04-23 US US17/442,386 patent/US12421526B2/en active Active
-
2021
- 2021-09-09 IL IL286212A patent/IL286212A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7524166B2 (ja) | 2024-07-29 |
| JPWO2020218419A1 (https=) | 2020-10-29 |
| IL286212A (en) | 2021-10-31 |
| CA3132447A1 (en) | 2020-10-29 |
| AU2020263757A1 (en) | 2021-10-14 |
| KR20220004072A (ko) | 2022-01-11 |
| US12421526B2 (en) | 2025-09-23 |
| KR102917057B1 (ko) | 2026-01-23 |
| EP3960755A1 (en) | 2022-03-02 |
| EP3960755A4 (en) | 2023-11-22 |
| US20220162637A1 (en) | 2022-05-26 |
| WO2020218419A1 (ja) | 2020-10-29 |
| CN113748122B (zh) | 2024-11-22 |
| AU2020263757B2 (en) | 2025-08-28 |
| CN113748122A (zh) | 2021-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112021017603A2 (pt) | Vírus adenoassociado (aav) mutante tendo propriedade de direcionamento para o cérebro | |
| MX358725B (es) | Antigenos prostaticos de consenso, molecula de acido nucleico que los codifica y vacuna y usos que los comprenden. | |
| PL404537A1 (pl) | Wirusy stowarzyszone z adenowirusem, kompozycje, wyizolowane bialko kapsydu, wyizolowana lub syntetyczna czasteczka kwasu nukleinowego, sposób wytwarzania rekombinowanych wirusów, komórki gospodarza, bialka obejmujace fragment bialka kapsydu AAV, sztuczne bialka, rekombinowane wirusy, czasteczki, sposoby dostarczania transgenu do komórki, sposób identyfikacji serotypu sekwencji wirusa (AAV), zestaw diagnostyczny, sposób izolacji nowych wirusów, nowe serotypy wirusa, wyizolowane wirusy, rekombinowana komórka, zastosowanie wirusa | |
| CO6470863A2 (es) | Mutantes fgf21 y usos de los mismos | |
| NZ603348A (en) | Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof | |
| MX9202724A (es) | Composicion que comprende un vector recombinante del agente lelystad y vacuna que comprende la misma. | |
| DK1586646T3 (da) | Lawsonia intracellularis-vaccine | |
| CN119013310A (zh) | 具有改善的编辑精确度的突变的胞嘧啶脱氨酶 | |
| BR112018007960A2 (pt) | conjugado, proteína pcrv, composição imunogênica, métodos de preparação de uma composição imunogênica, de tratamento e de produção de um bioconjugado, polinucleotídeo, vetor, célula hospedeira, e, bioconjugado. | |
| CO6210706A2 (es) | Upd-glucuronil transferasa y polinucleotido que codiifica la misma | |
| JP5614659B2 (ja) | Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター | |
| BR9803960A (pt) | Gene de desidrogenase de d-sorbitol. | |
| BR112023019228A2 (pt) | Peptídeo e composição contendo o peptídeo | |
| ATE470673T1 (de) | Impfstoffe mit lawsoniaintrazellularis- untereinheit | |
| WO2022120103A1 (en) | Engineering immune orthoganol aav and immune stealth crispr-cas | |
| ATE450545T1 (de) | Impfstoff mit lawsonia intracellularis- untereinheit | |
| Li et al. | Molecular cloning and functional characterization of duck nucleotide-binding oligomerization domain 1 (NOD1) | |
| AR012744A1 (es) | Molecula de acido nucleico que codifica una proteina vinculadora de sucrosa, proteina vinculadora de sucrosa y metodo para producir una proteinavinculadora de sucrosa. | |
| JP2025531824A (ja) | 受容体リガンドをタイリングするディスプレイされたペプチドを介したトロピズムのリプログラミング | |
| JPWO2008044567A1 (ja) | Ｈｌａ結合性ペプチド、その前駆体、それをコードするｄｎａ断片および組み換えベクター | |
| US20220364073A1 (en) | Engineering immune orthoganol aav and immune stealth crispr-cas | |
| ZA200602107B (en) | Piroplasmid vaccine | |
| CN114126627A (zh) | 作为疫苗佐剂的cd40特异性dna适体 | |
| RU2021133906A (ru) | Мутант aav, обладающий способностью нацеливаться на головной мозг | |
| Aggarwal | Factor H Cleavage by the Treponema denticola Protease Dentilisin: Understanding the Pathogenesis of Periodontal Disease |