IL286212A - Aav mutant having brain-targeting property - Google Patents
Aav mutant having brain-targeting propertyInfo
- Publication number
- IL286212A IL286212A IL286212A IL28621221A IL286212A IL 286212 A IL286212 A IL 286212A IL 286212 A IL286212 A IL 286212A IL 28621221 A IL28621221 A IL 28621221A IL 286212 A IL286212 A IL 286212A
- Authority
- IL
- Israel
- Prior art keywords
- brain targeting
- aav mutant
- closed brain
- aav
- mutant
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019082417 | 2019-04-24 | ||
| PCT/JP2020/017495 WO2020218419A1 (ja) | 2019-04-24 | 2020-04-23 | 脳に指向性を有するａａｖ変異体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL286212A true IL286212A (en) | 2021-10-31 |
Family
ID=72942142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL286212A IL286212A (en) | 2019-04-24 | 2021-09-09 | Aav mutant having brain-targeting property |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12421526B2 (https=) |
| EP (1) | EP3960755A4 (https=) |
| JP (1) | JP7524166B2 (https=) |
| KR (1) | KR102917057B1 (https=) |
| CN (1) | CN113748122B (https=) |
| AU (1) | AU2020263757B2 (https=) |
| BR (1) | BR112021017603A2 (https=) |
| CA (1) | CA3132447A1 (https=) |
| IL (1) | IL286212A (https=) |
| WO (1) | WO2020218419A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3575398A4 (en) * | 2017-01-30 | 2020-11-11 | Nippon Medical School Foundation | ADENO-ASSOCIATED VIRUS (AAV) CAPSIDE PROTEIN MUTANT |
| CN115960177B (zh) * | 2022-10-09 | 2023-07-07 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN116789739B (zh) * | 2022-12-08 | 2024-01-26 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN116284262B (zh) * | 2023-02-13 | 2026-03-17 | 和元生物技术（上海）股份有限公司 | 高效感染ht-22细胞的腺相关病毒突变体 |
| CN116693633B (zh) * | 2023-02-21 | 2023-12-22 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN121569040A (zh) | 2023-07-27 | 2026-02-24 | 宝生物工程株式会社 | 脑趋向性aav突变体 |
| CN121816425A (zh) * | 2023-09-11 | 2026-04-07 | 学校法人顺天堂 | 能够感染内耳的aav变体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| EP2176283B1 (en) | 2007-07-14 | 2016-11-02 | University of Iowa Research Foundation | Methods and compositions for treating brain diseases |
| WO2010114143A1 (ja) * | 2009-03-30 | 2010-10-07 | 国立大学法人岡山大学 | 特異的プロモーターの活性を上昇させるシステム及び該システムを保持したベクター |
| CN105755044A (zh) | 2011-04-22 | 2016-07-13 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体及其使用方法 |
| WO2013014764A1 (ja) | 2011-07-27 | 2013-01-31 | 三菱電機株式会社 | 通信システム、通信装置および通信方法 |
| US9938541B2 (en) | 2012-12-25 | 2018-04-10 | Takara Bio Inc. | AAV variant |
| HK1222673A1 (zh) | 2013-07-12 | 2017-07-07 | The Children's Hospital Of Philadelphia | Aav载体和用於抗aav(腺相关病毒)中和抗体的检测 |
| GB201403684D0 (en) | 2014-03-03 | 2014-04-16 | King S College London | Vector |
| CA2942289C (en) * | 2014-03-10 | 2024-05-21 | Uniqure Ip B.V. | Further improved aav vectors produced in insect cells |
| DE102014207498A1 (de) | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| US11364308B2 (en) * | 2016-05-13 | 2022-06-21 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and methods of use thereof |
| EP3890017B1 (en) | 2018-12-04 | 2025-08-13 | Ningbo Sunny Opotech Co., Ltd. | Photosensitive assembly, photographic module, manufacturing method for photographic assembly, and electronic device |
-
2020
- 2020-04-23 KR KR1020217035927A patent/KR102917057B1/ko active Active
- 2020-04-23 CA CA3132447A patent/CA3132447A1/en active Pending
- 2020-04-23 AU AU2020263757A patent/AU2020263757B2/en active Active
- 2020-04-23 JP JP2021516202A patent/JP7524166B2/ja active Active
- 2020-04-23 BR BR112021017603A patent/BR112021017603A2/pt unknown
- 2020-04-23 WO PCT/JP2020/017495 patent/WO2020218419A1/ja not_active Ceased
- 2020-04-23 CN CN202080030827.0A patent/CN113748122B/zh active Active
- 2020-04-23 EP EP20795029.6A patent/EP3960755A4/en active Pending
- 2020-04-23 US US17/442,386 patent/US12421526B2/en active Active
-
2021
- 2021-09-09 IL IL286212A patent/IL286212A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7524166B2 (ja) | 2024-07-29 |
| JPWO2020218419A1 (https=) | 2020-10-29 |
| BR112021017603A2 (pt) | 2021-11-16 |
| CA3132447A1 (en) | 2020-10-29 |
| AU2020263757A1 (en) | 2021-10-14 |
| KR20220004072A (ko) | 2022-01-11 |
| US12421526B2 (en) | 2025-09-23 |
| KR102917057B1 (ko) | 2026-01-23 |
| EP3960755A1 (en) | 2022-03-02 |
| EP3960755A4 (en) | 2023-11-22 |
| US20220162637A1 (en) | 2022-05-26 |
| WO2020218419A1 (ja) | 2020-10-29 |
| CN113748122B (zh) | 2024-11-22 |
| AU2020263757B2 (en) | 2025-08-28 |
| CN113748122A (zh) | 2021-12-03 |
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