BR112021017467A2 - Receptores de células t e métodos de uso dos mesmos - Google Patents

Receptores de células t e métodos de uso dos mesmos

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Publication number
BR112021017467A2
BR112021017467A2 BR112021017467A BR112021017467A BR112021017467A2 BR 112021017467 A2 BR112021017467 A2 BR 112021017467A2 BR 112021017467 A BR112021017467 A BR 112021017467A BR 112021017467 A BR112021017467 A BR 112021017467A BR 112021017467 A2 BR112021017467 A2 BR 112021017467A2
Authority
BR
Brazil
Prior art keywords
methods
nucleic acid
cell receptors
directed
nucleotide sequence
Prior art date
Application number
BR112021017467A
Other languages
English (en)
Inventor
Kayoko Saso
Kenji Murata
Naoto Hirano
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Publication of BR112021017467A2 publication Critical patent/BR112021017467A2/pt

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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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Abstract

receptores de células t e métodos de uso dos mesmos. a presente divulgação é dirigida a receptores de células t recombinantes capazes de se ligar a um epítopo gp100 e moléculas de ácido nucleico que codificam os mesmos. em algumas modalidades, as moléculas de ácido nucleico compreendem ainda uma segunda sequência de nucleotídeos, em que a segunda sequência de nucleotídeos ou o polipeptídeo codificado pela segunda sequência de nucleotídeos inibe a expressão de um tcr endógeno. outros aspectos da divulgação são direcionados a vetores que compreendem a molécula de ácido nucleico e células que compreendem o tcr recombinante, a molécula de ácido nucleico ou o vetor. ainda outros aspectos da divulgação são direcionados a métodos de uso dos mesmos. em algumas modalidades, os métodos compreendem o tratamento de um câncer em um indivíduo em necessidade do mesmo.
BR112021017467A 2019-03-04 2020-03-03 Receptores de células t e métodos de uso dos mesmos BR112021017467A2 (pt)

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PCT/IB2020/051811 WO2020178742A1 (en) 2019-03-04 2020-03-03 T cell receptors and methods of use thereof

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EP (1) EP3935177A4 (pt)
JP (1) JP2022524993A (pt)
KR (1) KR20210144740A (pt)
CN (1) CN113795585A (pt)
AU (1) AU2020231107A1 (pt)
BR (1) BR112021017467A2 (pt)
CA (1) CA3132434A1 (pt)
IL (1) IL286041A (pt)
MX (1) MX2021010539A (pt)
SG (1) SG11202109593SA (pt)
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US8216565B2 (en) * 2007-01-12 2012-07-10 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services GP100-specific T cell receptors and related materials and methods of use
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring

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EP3935177A4 (en) 2023-01-04
US20220152105A1 (en) 2022-05-19
CN113795585A (zh) 2021-12-14
IL286041A (en) 2021-10-31
JP2022524993A (ja) 2022-05-11
CA3132434A1 (en) 2020-09-10
SG11202109593SA (en) 2021-10-28
WO2020178742A1 (en) 2020-09-10
AU2020231107A1 (en) 2021-09-30
EP3935177A1 (en) 2022-01-12
TW202100544A (zh) 2021-01-01
KR20210144740A (ko) 2021-11-30
MX2021010539A (es) 2021-12-15

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