MX2021010539A - Receptores de linfocitos t y metodos de uso de estos. - Google Patents

Receptores de linfocitos t y metodos de uso de estos.

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Publication number
MX2021010539A
MX2021010539A MX2021010539A MX2021010539A MX2021010539A MX 2021010539 A MX2021010539 A MX 2021010539A MX 2021010539 A MX2021010539 A MX 2021010539A MX 2021010539 A MX2021010539 A MX 2021010539A MX 2021010539 A MX2021010539 A MX 2021010539A
Authority
MX
Mexico
Prior art keywords
nucleic acid
methods
nucleotide sequence
directed
cell receptors
Prior art date
Application number
MX2021010539A
Other languages
English (en)
Inventor
Naoto Hirano
Kenji Murata
Kayoko Saso
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Publication of MX2021010539A publication Critical patent/MX2021010539A/es

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Abstract

La presente descripción se refiere a receptores de linfocitos T recombinantes capaces de unirse a un epítopo de gp100 y moléculas de ácido nucleico que los codifican. En algunas modalidades, las moléculas de ácido nucleico comprenden además una segunda secuencia de nucleótidos, donde la segunda secuencia de nucleótidos o el polipéptido codificado por la segunda secuencia de nucleótidos inhibe la expresión de un TCR endógeno. Otros aspectos de la descripción se refieren a vectores que comprenden la molécula de ácido nucleico y células que comprenden el TCR recombinante, la molécula de ácido nucleico o el vector. Otros aspectos adicionales de la descripción se refieren a métodos para usarlos. En algunas modalidades, los métodos comprenden tratar un cáncer en un sujeto que lo necesita.
MX2021010539A 2019-03-04 2020-03-03 Receptores de linfocitos t y metodos de uso de estos. MX2021010539A (es)

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PCT/IB2020/051811 WO2020178742A1 (en) 2019-03-04 2020-03-03 T cell receptors and methods of use thereof

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EP (1) EP3935177A4 (es)
JP (1) JP2022524993A (es)
KR (1) KR20210144740A (es)
CN (1) CN113795585A (es)
AU (1) AU2020231107A1 (es)
BR (1) BR112021017467A2 (es)
CA (1) CA3132434A1 (es)
IL (1) IL286041A (es)
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SG (1) SG11202109593SA (es)
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PL3551221T3 (pl) 2016-12-08 2022-02-28 Immatics Biotechnologies Gmbh Nowe receptory komórek t i immunoterapia z ich zastosowaniem

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US8216565B2 (en) * 2007-01-12 2012-07-10 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services GP100-specific T cell receptors and related materials and methods of use
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring

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CN113795585A (zh) 2021-12-14
SG11202109593SA (en) 2021-10-28
BR112021017467A2 (pt) 2021-11-16
AU2020231107A1 (en) 2021-09-30
WO2020178742A1 (en) 2020-09-10
US20220152105A1 (en) 2022-05-19
JP2022524993A (ja) 2022-05-11
EP3935177A1 (en) 2022-01-12
EP3935177A4 (en) 2023-01-04
TW202100544A (zh) 2021-01-01
IL286041A (en) 2021-10-31
CA3132434A1 (en) 2020-09-10
KR20210144740A (ko) 2021-11-30

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