BR112021011642A2 - Variantes de igg fc para uso veterinário - Google Patents
Variantes de igg fc para uso veterinárioInfo
- Publication number
- BR112021011642A2 BR112021011642A2 BR112021011642A BR112021011642A BR112021011642A2 BR 112021011642 A2 BR112021011642 A2 BR 112021011642A2 BR 112021011642 A BR112021011642 A BR 112021011642A BR 112021011642 A BR112021011642 A BR 112021011642A BR 112021011642 A2 BR112021011642 A2 BR 112021011642A2
- Authority
- BR
- Brazil
- Prior art keywords
- igg
- polypeptides
- various embodiments
- variants
- veterinary use
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000003247 decreasing effect Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- 241000283086 Equidae Species 0.000 abstract 1
- 241000282326 Felis catus Species 0.000 abstract 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 abstract 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 abstract 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 abstract 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
variantes de igg fc para uso veterinário. a presente invenção refere-se a várias modalidades referentes a polipeptídeos de igg fc variante de animais de estimação apresentando ligação aumentada da proteína a para facilidade de purificação, ligação diminuída à c1q para respostas imunológicas mediadas pelo complemento reduzidas, ligação diminuída à cd16 (por exemplo, para indução reduzida de citotoxicidade celular anticorpo-dependente (adcc)), estabilidade aumentada, e/ou a capacidade de formar proteínas multiméricas. além disso, a presente invenção apresenta várias modalidades referentes a anticorpos e proteínas de fusão compreendendo tais polipeptídeos de igg fc variante. em várias modalidades, tais polipeptídeos podem ser usados para tratar animais de estimação, tais como cães, gatos e cavalos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862785680P | 2018-12-27 | 2018-12-27 | |
PCT/US2019/068629 WO2020139984A1 (en) | 2018-12-27 | 2019-12-26 | Igg fc variants for veterinary use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021011642A2 true BR112021011642A2 (pt) | 2021-11-03 |
Family
ID=71126391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021011642A BR112021011642A2 (pt) | 2018-12-27 | 2019-12-26 | Variantes de igg fc para uso veterinário |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220064263A1 (pt) |
EP (1) | EP3902564A4 (pt) |
JP (1) | JP2022516027A (pt) |
KR (1) | KR20210110827A (pt) |
CN (1) | CN113453716A (pt) |
AU (1) | AU2019416344A1 (pt) |
BR (1) | BR112021011642A2 (pt) |
CA (1) | CA3123623A1 (pt) |
MX (1) | MX2021007680A (pt) |
WO (1) | WO2020139984A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
EP3906259A2 (en) | 2019-01-03 | 2021-11-10 | Invetx Inc. | Compositions for increasing half-life of a therapeutic agent in canines and methods of use |
BR112021018156A2 (pt) * | 2019-03-20 | 2021-11-16 | Kindred Biosciences Inc | Antagonistas de ngf para uso médico |
KR20230034954A (ko) | 2020-05-11 | 2023-03-10 | 인베티엑스 인코포레이티드 | 개에서 치료제의 반감기를 증가시키기 위한 조성물 및 사용 방법 |
EP4178977A1 (en) | 2020-07-10 | 2023-05-17 | Invetx, Inc. | Compositions for increasing half-life of a therapeutic agent in felines and methods of use |
AU2022321899A1 (en) * | 2021-08-06 | 2024-02-08 | Petmedix Ltd | Antibody fc variants |
KR20230047014A (ko) | 2021-09-29 | 2023-04-06 | 카오티에스 주식회사 | 신규한 재조합 Fc 수용체 및 이를 포함하는 세포 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US20090010920A1 (en) * | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
WO2010117760A2 (en) * | 2009-03-30 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Fusion proteins comprising canine fc portions |
JP2013537416A (ja) * | 2010-08-13 | 2013-10-03 | メディミューン リミテッド | 変異型Fc領域を含むモノマーポリペプチド及び使用方法 |
HUE041335T2 (hu) * | 2011-03-29 | 2019-05-28 | Roche Glycart Ag | Antitest FC-variánsok |
WO2013063186A2 (en) * | 2011-10-26 | 2013-05-02 | Novartis Animal Health Us, Inc. | Monoclonal antibodies and methods of use |
CN104684928A (zh) * | 2012-08-02 | 2015-06-03 | Jn生物科学有限责任公司 | 通过半胱氨酸突变和μ尾端多聚化的抗体或融合蛋白 |
WO2014093387A1 (en) * | 2012-12-10 | 2014-06-19 | Kindred Biosciences, Inc. | Vegf receptor fusion proteins for veterinary use |
US9487587B2 (en) * | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
CA3185195A1 (en) * | 2013-12-20 | 2015-06-25 | Intervet International B.V. | Antibodies against canine pd-1 |
CN107074952B (zh) * | 2014-09-30 | 2021-04-09 | 英特维特国际股份有限公司 | 结合犬pd-l1的pd-l1抗体 |
US20180009869A1 (en) * | 2016-07-08 | 2018-01-11 | AskGene Pharma, Inc. | Fusion Protein Comprising Leptin and Methods for Producing and Using the Same |
US20200181258A1 (en) * | 2016-10-17 | 2020-06-11 | Vetoquinol Sa | Modified antibody constant region |
US20200362034A1 (en) * | 2017-08-15 | 2020-11-19 | Kindred Biosciences, Inc. | IgG Fc Variants for Veterinary Use |
WO2020056393A1 (en) * | 2018-09-14 | 2020-03-19 | Kindred Biosciences, Inc. | Anti-il4 receptor antibodies for veterinary use |
MX2021004313A (es) * | 2018-10-18 | 2021-05-27 | Kindred Biosciences Inc | Variantes de fc con union alterada al receptor de fc neonatal (fcrn) para uso veterinario. |
US20210395340A1 (en) * | 2018-10-25 | 2021-12-23 | Kindred Biosciences, Inc. | IL4/IL13 Receptor Molecule for Veterinary Use |
CN113423721A (zh) * | 2018-12-12 | 2021-09-21 | 金德雷德生物科学股份有限公司 | 兽用促红细胞生成素类似物 |
BR112021018156A2 (pt) * | 2019-03-20 | 2021-11-16 | Kindred Biosciences Inc | Antagonistas de ngf para uso médico |
-
2019
- 2019-12-26 KR KR1020217021508A patent/KR20210110827A/ko unknown
- 2019-12-26 JP JP2021536344A patent/JP2022516027A/ja active Pending
- 2019-12-26 AU AU2019416344A patent/AU2019416344A1/en active Pending
- 2019-12-26 WO PCT/US2019/068629 patent/WO2020139984A1/en unknown
- 2019-12-26 CN CN201980092363.3A patent/CN113453716A/zh active Pending
- 2019-12-26 US US17/414,637 patent/US20220064263A1/en active Pending
- 2019-12-26 MX MX2021007680A patent/MX2021007680A/es unknown
- 2019-12-26 CA CA3123623A patent/CA3123623A1/en active Pending
- 2019-12-26 EP EP19905074.1A patent/EP3902564A4/en active Pending
- 2019-12-26 BR BR112021011642A patent/BR112021011642A2/pt unknown
Also Published As
Publication number | Publication date |
---|---|
EP3902564A4 (en) | 2022-09-28 |
CN113453716A (zh) | 2021-09-28 |
US20220064263A1 (en) | 2022-03-03 |
CA3123623A1 (en) | 2020-07-02 |
WO2020139984A1 (en) | 2020-07-02 |
EP3902564A1 (en) | 2021-11-03 |
MX2021007680A (es) | 2021-10-13 |
AU2019416344A1 (en) | 2021-07-01 |
JP2022516027A (ja) | 2022-02-24 |
KR20210110827A (ko) | 2021-09-09 |
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