BR112021010447A2 - Análogos de peptídeos gip modificados - Google Patents
Análogos de peptídeos gip modificados Download PDFInfo
- Publication number
- BR112021010447A2 BR112021010447A2 BR112021010447-0A BR112021010447A BR112021010447A2 BR 112021010447 A2 BR112021010447 A2 BR 112021010447A2 BR 112021010447 A BR112021010447 A BR 112021010447A BR 112021010447 A2 BR112021010447 A2 BR 112021010447A2
- Authority
- BR
- Brazil
- Prior art keywords
- gip
- seq
- amino acid
- diacid
- cex
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18209896 | 2018-12-03 | ||
| EP18209896.2 | 2018-12-03 | ||
| EP19176739.1 | 2019-05-27 | ||
| EP19176739 | 2019-05-27 | ||
| PCT/EP2019/083506 WO2020115048A1 (en) | 2018-12-03 | 2019-12-03 | Modified gip peptide analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021010447A2 true BR112021010447A2 (pt) | 2021-08-24 |
Family
ID=68731999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021010447-0A BR112021010447A2 (pt) | 2018-12-03 | 2019-12-03 | Análogos de peptídeos gip modificados |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US12297250B2 (https=) |
| EP (2) | EP3891173A1 (https=) |
| JP (1) | JP7605747B2 (https=) |
| KR (2) | KR20260011770A (https=) |
| CN (3) | CN121449721A (https=) |
| AU (2) | AU2019391300B2 (https=) |
| BR (1) | BR112021010447A2 (https=) |
| CA (1) | CA3121043A1 (https=) |
| IL (1) | IL283385A (https=) |
| MX (1) | MX2021006505A (https=) |
| SG (1) | SG11202105586YA (https=) |
| WO (2) | WO2020115048A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3157387A1 (en) * | 2019-12-03 | 2021-06-10 | Mette Marie Rosenkilde | Optimized gip peptide analogues |
| CN116113429A (zh) * | 2020-07-06 | 2023-05-12 | 鸿绪生物医药科技（北京）有限公司 | 新型多肽及其治疗用途 |
| WO2022007809A1 (zh) * | 2020-07-06 | 2022-01-13 | 鸿绪生物医药科技（北京）有限公司 | 新型多肽制剂及其治疗用途 |
| WO2022159395A1 (en) | 2021-01-20 | 2022-07-28 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| KR20240021212A (ko) * | 2021-06-10 | 2024-02-16 | 안타그 테라퓨틱스 에이피에스 | 비만 및 비만-관련 장애의 치료 |
| MX2024003236A (es) | 2021-09-15 | 2024-06-19 | Viking Therapeutics Inc | Composiciones y metodos para el tratamiento de trastornos metabolicos y hepaticos. |
| WO2023139106A2 (en) | 2022-01-18 | 2023-07-27 | Novo Nordisk A/S | Long-acting gipr antagonists |
| UY40349A (es) * | 2022-07-13 | 2024-01-31 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Agonista dual de glp-1/gip, método de preparación y uso del mismo |
| CN118255864A (zh) * | 2022-12-26 | 2024-06-28 | 杭州中美华东制药有限公司 | Gip受体激动剂及其用途 |
| CN116120425A (zh) * | 2022-12-27 | 2023-05-16 | 南京赛诺生物技术有限公司 | 一种glp-1/gip受体双重激动剂及其应用 |
| GB202302686D0 (en) * | 2023-02-24 | 2023-04-12 | Imperial College Innovations Ltd | Novel compounds |
| CN121464151A (zh) * | 2023-02-24 | 2026-02-03 | Ip2Ipo创新有限公司 | 化合物 |
| WO2024209050A1 (en) * | 2023-04-05 | 2024-10-10 | Antag Therapeutics Aps | Gip activity modulators and orthostatic intolerance |
| AR134436A1 (es) * | 2023-11-22 | 2026-01-14 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Uso de un agonista dual glp-1r / gipr en la fabricación de un medicamento veterinario |
| WO2025154021A1 (en) * | 2024-01-19 | 2025-07-24 | Takeda Pharmaceutical Company Limited | Improved gip receptor agonist peptide compounds and uses thereof |
| WO2025154020A1 (en) * | 2024-01-19 | 2025-07-24 | Takeda Pharmaceutical Company Limited | Improved gip receptor agonist peptide compounds and uses thereof |
| WO2025176999A2 (en) * | 2024-02-23 | 2025-08-28 | Ip2Ipo Innovations Limited | Novel compounds |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US5745335A (en) | 1996-06-27 | 1998-04-28 | Gennum Corporation | Multi-layer film capacitor structures and method |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6384016B1 (en) | 1998-03-13 | 2002-05-07 | Novo Nordisk A/S | Stabilized aqueous peptide solutions |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| WO1998024464A1 (en) | 1996-12-03 | 1998-06-11 | Trustees Of Boston University | Specific antagonists for glucose-dependent insulinotropic polypeptide (gip) |
| DE69900026T2 (de) | 1998-01-30 | 2001-05-10 | Novo Nordisk As | Eine injektionsspritze |
| JP2003522099A (ja) | 1998-02-27 | 2003-07-22 | ノボ ノルディスク アクティーゼルスカブ | 遅延作用プロファイルを有するｇｌｐ−１のｇｌｐ−１誘導体及びエキセンジン |
| JP2002526554A (ja) | 1998-10-07 | 2002-08-20 | メディカル カレッジ オブ ジョージア リサーチ インスティチュート，インコーポレイテッド | 骨親和性ホルモンとして用いられるグルコース依存性インスリン親和性ペプチド |
| DE69922043T2 (de) | 1998-12-07 | 2005-11-24 | Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. | Glp-1 analoge |
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| PT1171465E (pt) | 1999-03-29 | 2004-12-31 | Uutech Ltd | Analogos de petido inibidor gastrico e sua utilizacao para o tratamento de diabetes |
| GB0404124D0 (en) | 2004-02-25 | 2004-03-31 | Univ Ulster | Antagonists of GIP |
| BR0116024A (pt) | 2000-12-07 | 2005-12-13 | Lilly Co Eli | Proteìna de fusão heteróloga e uso da mesma |
| EP1444810B1 (en) | 2001-09-21 | 2006-12-06 | Koninklijke Philips Electronics N.V. | No specific control module? use less specific one |
| US20030232761A1 (en) | 2002-03-28 | 2003-12-18 | Hinke Simon A. | Novel analogues of glucose-dependent insulinotropic polypeptide |
| US20050059605A1 (en) | 2003-01-31 | 2005-03-17 | Krishna Peri | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
| BRPI0606992A2 (pt) * | 2005-02-11 | 2009-07-28 | Amylin Pharmaceuticals Inc | análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| WO2007109354A2 (en) | 2006-03-21 | 2007-09-27 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of using same |
| JP2011530507A (ja) | 2008-08-07 | 2011-12-22 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | グルコース依存性インスリン分泌刺激ポリペプチドアナログ |
| KR101417873B1 (ko) | 2008-08-07 | 2014-07-09 | 입센 파마 에스.에이.에스 | 포도당 의존적인 인슐린 분비 자극성 폴리펩타이드의 유사체 |
| US8450266B2 (en) | 2008-08-07 | 2013-05-28 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide |
| WO2010016936A1 (en) | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide |
| AU2009280021B2 (en) | 2008-08-07 | 2012-10-04 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal |
| US9023986B2 (en) | 2010-10-25 | 2015-05-05 | Hoffmann-La Roche Inc. | Glucose-dependent insulinotropic peptide analogs |
| SG191252A1 (en) | 2010-12-22 | 2013-07-31 | Marcadia Biotech Inc | Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides |
| WO2012167744A1 (en) | 2011-06-10 | 2012-12-13 | Beijing Hanmi Pharmaceutical Co., Ltd. | Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof |
| CA2877358A1 (en) * | 2012-06-21 | 2013-12-27 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting gip receptor activity |
| TW201625668A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| US10968266B2 (en) | 2014-09-05 | 2021-04-06 | University Of Copenhagen | GIP peptide analogues |
| US10253078B2 (en) | 2014-10-29 | 2019-04-09 | Zealand Pharma A/S | GIP agonist compounds and methods |
| WO2016205488A1 (en) | 2015-06-17 | 2016-12-22 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| WO2018069442A1 (en) | 2016-10-12 | 2018-04-19 | University Of Copenhagen | Peptide dual agonists of gipr and glp2r |
| US20190352335A1 (en) * | 2016-12-19 | 2019-11-21 | Hanmi Pharm. Co., Ltd. | Brain targeting long-acting protein conjugate |
| WO2018124009A1 (ja) | 2016-12-26 | 2018-07-05 | 花王株式会社 | 低体温改善剤 |
| CN110087686A (zh) | 2016-12-26 | 2019-08-02 | 花王株式会社 | 认知功能改善剂 |
| CN110139672A (zh) | 2016-12-26 | 2019-08-16 | 花王株式会社 | 运动调节功能提高剂 |
| PL3630806T3 (pl) | 2017-05-31 | 2024-05-13 | The University Of Copenhagen | Analogi peptydów gip o długotrwałym działaniu |
-
2019
- 2019-12-03 CN CN202511386365.7A patent/CN121449721A/zh active Pending
- 2019-12-03 CN CN201980090373.3A patent/CN113366014B/zh active Active
- 2019-12-03 CA CA3121043A patent/CA3121043A1/en active Pending
- 2019-12-03 JP JP2021552785A patent/JP7605747B2/ja active Active
- 2019-12-03 WO PCT/EP2019/083506 patent/WO2020115048A1/en not_active Ceased
- 2019-12-03 MX MX2021006505A patent/MX2021006505A/es unknown
- 2019-12-03 SG SG11202105586YA patent/SG11202105586YA/en unknown
- 2019-12-03 AU AU2019391300A patent/AU2019391300B2/en active Active
- 2019-12-03 KR KR1020257043349A patent/KR20260011770A/ko active Pending
- 2019-12-03 CN CN202511386362.3A patent/CN121449720A/zh active Pending
- 2019-12-03 US US17/298,512 patent/US12297250B2/en active Active
- 2019-12-03 US US17/298,444 patent/US12187773B2/en active Active
- 2019-12-03 EP EP19812788.8A patent/EP3891173A1/en active Pending
- 2019-12-03 WO PCT/EP2019/083509 patent/WO2020115049A1/en not_active Ceased
- 2019-12-03 EP EP19812789.6A patent/EP3891174A1/en active Pending
- 2019-12-03 BR BR112021010447-0A patent/BR112021010447A2/pt unknown
- 2019-12-03 KR KR1020217019677A patent/KR102906485B1/ko active Active
-
2021
- 2021-05-24 IL IL283385A patent/IL283385A/en unknown
-
2025
- 2025-03-31 US US19/096,393 patent/US20250376499A1/en active Pending
- 2025-09-24 AU AU2025237957A patent/AU2025237957A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210102911A (ko) | 2021-08-20 |
| AU2025237957A1 (en) | 2025-10-16 |
| CN113366014B (zh) | 2025-10-21 |
| IL283385A (en) | 2021-07-29 |
| US20250376499A1 (en) | 2025-12-11 |
| US12187773B2 (en) | 2025-01-07 |
| CN121449720A (zh) | 2026-02-03 |
| JP2022509568A (ja) | 2022-01-20 |
| CN113366014A (zh) | 2021-09-07 |
| SG11202105586YA (en) | 2021-06-29 |
| EP3891174A1 (en) | 2021-10-13 |
| US12297250B2 (en) | 2025-05-13 |
| US20220025010A1 (en) | 2022-01-27 |
| MX2021006505A (es) | 2021-10-01 |
| KR102906485B1 (ko) | 2025-12-31 |
| KR20260011770A (ko) | 2026-01-23 |
| WO2020115049A1 (en) | 2020-06-11 |
| EP3891173A1 (en) | 2021-10-13 |
| US20220298218A1 (en) | 2022-09-22 |
| CN121449721A (zh) | 2026-02-03 |
| CA3121043A1 (en) | 2020-06-11 |
| AU2019391300B2 (en) | 2025-06-26 |
| WO2020115048A1 (en) | 2020-06-11 |
| AU2019391300A1 (en) | 2021-07-01 |
| JP7605747B2 (ja) | 2024-12-24 |
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