BR112021007362A2 - inibidores da replicação do vírus da imunodeficiência humana - Google Patents

Info

Publication number

BR112021007362A2

BR112021007362A2 BR112021007362-0A BR112021007362A BR112021007362A2 BR 112021007362 A2 BR112021007362 A2 BR 112021007362A2 BR 112021007362 A BR112021007362 A BR 112021007362A BR 112021007362 A2 BR112021007362 A2 BR 112021007362A2

Authority

BR

Brazil

Prior art keywords

chloro

compound

indazol

ethyl

chs

Prior art date

2018-10-24

Links

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• Global Dossier
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• 239000003112 inhibitor Substances 0.000 title claims abstract description 13
• 241000725303 Human immunodeficiency virus Species 0.000 title abstract description 19
• 230000029812 viral genome replication Effects 0.000 title abstract description 3
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 43
• -1 -CHF2 Chemical group 0.000 claims description 38
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 24
• 230000015572 biosynthetic process Effects 0.000 claims description 18
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• 208000031886 HIV Infections Diseases 0.000 claims description 14
• 208000037357 HIV infectious disease Diseases 0.000 claims description 14
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 14
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 14
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 11
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• 101710158708 RNA-splicing ligase RtcB homolog Proteins 0.000 claims description 9
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• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
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• 238000010254 subcutaneous injection Methods 0.000 claims 1
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• 208000015181 infectious disease Diseases 0.000 abstract description 2
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• 239000012267 brine Substances 0.000 description 60
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 60
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• 238000005481 NMR spectroscopy Methods 0.000 description 53
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• HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 41
• 239000000706 filtrate Substances 0.000 description 39
• 239000002904 solvent Substances 0.000 description 39
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• 239000012043 crude product Substances 0.000 description 26
• 238000000746 purification Methods 0.000 description 26
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• 239000002253 acid Substances 0.000 description 25
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 24
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