BR112020020246A8 - Inibidores de cinase axl e uso dos mesmos - Google Patents
Inibidores de cinase axl e uso dos mesmosInfo
- Publication number
- BR112020020246A8 BR112020020246A8 BR112020020246A BR112020020246A BR112020020246A8 BR 112020020246 A8 BR112020020246 A8 BR 112020020246A8 BR 112020020246 A BR112020020246 A BR 112020020246A BR 112020020246 A BR112020020246 A BR 112020020246A BR 112020020246 A8 BR112020020246 A8 BR 112020020246A8
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- axl kinase
- crystalline forms
- tartrate salts
- axl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862653394P | 2018-04-05 | 2018-04-05 | |
| US62/653,394 | 2018-04-05 | ||
| US201862663146P | 2018-04-26 | 2018-04-26 | |
| US62/663,146 | 2018-04-26 | ||
| US201862678980P | 2018-05-31 | 2018-05-31 | |
| US62/678,980 | 2018-05-31 | ||
| US201862688161P | 2018-06-21 | 2018-06-21 | |
| US62/688,161 | 2018-06-21 | ||
| US201862695609P | 2018-07-09 | 2018-07-09 | |
| US62/695,609 | 2018-07-09 | ||
| US201862698638P | 2018-07-16 | 2018-07-16 | |
| US62/698,638 | 2018-07-16 | ||
| US201862760882P | 2018-11-13 | 2018-11-13 | |
| US62/760,882 | 2018-11-13 | ||
| US201862767475P | 2018-11-14 | 2018-11-14 | |
| US62/767,475 | 2018-11-14 | ||
| US201862778856P | 2018-12-12 | 2018-12-12 | |
| US62/778,856 | 2018-12-12 | ||
| US201962813705P | 2019-03-04 | 2019-03-04 | |
| US62/813,705 | 2019-03-04 | ||
| PCT/US2019/026094 WO2019195753A1 (en) | 2018-04-05 | 2019-04-05 | Axl kinase inhibitors and use of the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112020020246A2 BR112020020246A2 (pt) | 2021-01-12 |
| BR112020020246A8 true BR112020020246A8 (pt) | 2022-10-18 |
Family
ID=68101236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020020246A BR112020020246A8 (pt) | 2018-04-05 | 2019-04-05 | Inibidores de cinase axl e uso dos mesmos |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11013741B1 (https=) |
| EP (1) | EP3773591A4 (https=) |
| JP (1) | JP2021524835A (https=) |
| KR (1) | KR20210003780A (https=) |
| CN (1) | CN112533602A (https=) |
| AU (1) | AU2019247498A1 (https=) |
| BR (1) | BR112020020246A8 (https=) |
| CA (1) | CA3096984A1 (https=) |
| IL (1) | IL277600A (https=) |
| MX (1) | MX2020010437A (https=) |
| PH (1) | PH12020551853A1 (https=) |
| SG (1) | SG11202009443RA (https=) |
| WO (1) | WO2019195753A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX394360B (es) | 2013-03-14 | 2025-03-24 | Sumitomo Pharma Oncology Inc | Inhibidores de jak2 y alk2 y metodos para su uso. |
| KR20210003780A (ko) | 2018-04-05 | 2021-01-12 | 스미토모 다이니폰 파마 온콜로지, 인크. | Axl 키나제 억제제 및 그의 용도 |
| AU2019310590A1 (en) | 2018-07-26 | 2021-01-14 | Sumitomo Pharma Oncology, Inc. | Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| JP2022551439A (ja) * | 2019-10-04 | 2022-12-09 | スミトモ ファーマ オンコロジー， インコーポレイテッド | Ａｘｌ阻害薬製剤 |
| US12577211B2 (en) | 2020-06-29 | 2026-03-17 | Bacainn Biotherapeutics, Ltd. | Probenecid compounds for the treatment of inflammasome-mediated lung disease |
| MX2023000810A (es) * | 2020-07-19 | 2023-05-19 | Aravive Inc | Metodos de diagnostico para el cancer utilizando receptores señuelo axl. |
| EP4464699A1 (en) * | 2022-01-14 | 2024-11-20 | Lisen Therapeutics, Inc. | Pyrimidine-2,4-diamine derivatives as well as preparation method therefor and use thereof |
| WO2024097229A1 (en) * | 2022-11-04 | 2024-05-10 | Bacainn Biotherapeutics, Inc. | Probenecid compounds for the treatment of inflammasome-mediated dermatological conditions |
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-
2019
- 2019-04-05 KR KR1020207031834A patent/KR20210003780A/ko not_active Withdrawn
- 2019-04-05 US US16/376,452 patent/US11013741B1/en not_active Expired - Fee Related
- 2019-04-05 SG SG11202009443RA patent/SG11202009443RA/en unknown
- 2019-04-05 WO PCT/US2019/026094 patent/WO2019195753A1/en not_active Ceased
- 2019-04-05 JP JP2020523746A patent/JP2021524835A/ja active Pending
- 2019-04-05 EP EP19780739.9A patent/EP3773591A4/en not_active Withdrawn
- 2019-04-05 CA CA3096984A patent/CA3096984A1/en active Pending
- 2019-04-05 CN CN201980033174.9A patent/CN112533602A/zh active Pending
- 2019-04-05 BR BR112020020246A patent/BR112020020246A8/pt not_active IP Right Cessation
- 2019-04-05 MX MX2020010437A patent/MX2020010437A/es unknown
- 2019-04-05 AU AU2019247498A patent/AU2019247498A1/en not_active Abandoned
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2020
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- 2020-11-03 PH PH12020551853A patent/PH12020551853A1/en unknown
- 2020-11-09 US US17/092,521 patent/US11400091B2/en active Active
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2022
- 2022-06-09 US US17/836,698 patent/US20230165857A1/en not_active Abandoned
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| CA3096984A1 (en) | 2019-10-10 |
| US11013741B1 (en) | 2021-05-25 |
| EP3773591A1 (en) | 2021-02-17 |
| US20210205304A1 (en) | 2021-07-08 |
| WO2019195753A1 (en) | 2019-10-10 |
| PH12020551853A1 (en) | 2021-07-19 |
| US11400091B2 (en) | 2022-08-02 |
| EP3773591A4 (en) | 2021-12-22 |
| KR20210003780A (ko) | 2021-01-12 |
| CN112533602A (zh) | 2021-03-19 |
| JP2021524835A (ja) | 2021-09-16 |
| IL277600A (en) | 2020-11-30 |
| MX2020010437A (es) | 2021-01-29 |
| AU2019247498A1 (en) | 2020-11-26 |
| US20230165857A1 (en) | 2023-06-01 |
| BR112020020246A2 (pt) | 2021-01-12 |
| SG11202009443RA (en) | 2020-10-29 |
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