BR112019025497B8 - Célula de fluxo com coletor integrado - Google Patents

Célula de fluxo com coletor integrado

Info

Publication number
BR112019025497B8
BR112019025497B8 BR112019025497A BR112019025497A BR112019025497B8 BR 112019025497 B8 BR112019025497 B8 BR 112019025497B8 BR 112019025497 A BR112019025497 A BR 112019025497A BR 112019025497 A BR112019025497 A BR 112019025497A BR 112019025497 B8 BR112019025497 B8 BR 112019025497B8
Authority
BR
Brazil
Prior art keywords
flow cell
detection section
collector
flow
fluid communication
Prior art date
Application number
BR112019025497A
Other languages
English (en)
Other versions
BR112019025497B1 (pt
BR112019025497A2 (pt
Inventor
Lin Sz-Chin
Taylor Jay
Rhee Minsoung
Foley Jennifer
Cox-Muranami Wesley
Delattre Cyril
Khurana Tarun
Crivelli Paul
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of BR112019025497A2 publication Critical patent/BR112019025497A2/pt
Publication of BR112019025497B1 publication Critical patent/BR112019025497B1/pt
Publication of BR112019025497B8 publication Critical patent/BR112019025497B8/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Em um exemplo, uma célula de fluxo inclui uma pluralidade de orifícios de entrada dimensionados para receber um fluxo de reagente de um dentre uma pluralidade de reagentes para a célula de fluxo. Uma porta de saída da célula de fluxo é dimensionada para passar cada fluxo de reagente para fora da célula de fluxo. Um canal de fluxo da célula de fluxo é posicionado entre e em comunicação fluida com cada porta de entrada e porta de saída. O canal de fluxo inclui uma seção do coletor e uma seção de detecção. A seção do coletor tem uma pluralidade de ramificações do coletor em comunicação fluida com uma linha comum, em que cada ramificação é conectada a uma de cada porta de entrada. A seção de detecção está em comunicação fluida com a linha comum e a porta de saída. A seção de detecção é operável para executar uma pluralidade de reações químicas diferentes entre a pluralidade de reagentes e analitos posicionados na seção de detecção.
BR112019025497A 2018-05-04 2019-04-30 Célula de fluxo com coletor integrado BR112019025497B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862666897P 2018-05-04 2018-05-04
US62/666,897 2018-05-04
PCT/US2019/029783 WO2019213007A1 (en) 2018-05-04 2019-04-30 Flow cell with integrated manifold

Publications (3)

Publication Number Publication Date
BR112019025497A2 BR112019025497A2 (pt) 2020-06-23
BR112019025497B1 BR112019025497B1 (pt) 2022-11-16
BR112019025497B8 true BR112019025497B8 (pt) 2023-01-24

Family

ID=68384557

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019025497A BR112019025497B8 (pt) 2018-05-04 2019-04-30 Célula de fluxo com coletor integrado

Country Status (15)

Country Link
US (2) US11376584B2 (pt)
EP (1) EP3788383B1 (pt)
JP (1) JP7001716B2 (pt)
KR (1) KR102401249B1 (pt)
CN (2) CN110441472B (pt)
AU (1) AU2019261940B2 (pt)
BR (1) BR112019025497B8 (pt)
CA (1) CA3067426C (pt)
ES (1) ES2965840T3 (pt)
IL (1) IL270849A (pt)
NZ (1) NZ759550A (pt)
RU (1) RU2748394C1 (pt)
SA (1) SA519410819B1 (pt)
TW (1) TWI714069B (pt)
WO (1) WO2019213007A1 (pt)

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WO2021138002A1 (en) * 2019-12-30 2021-07-08 Illumina, Inc. Systems for monitoring fluidics in reagent cartridges and related methods
AU2020418901A1 (en) * 2019-12-30 2022-07-21 Illumina, Inc. Flow cell assemblies and related reagent selector valves
KR20230004702A (ko) * 2020-04-20 2023-01-06 엠쥐아이 테크 컴퍼니 엘티디. 액체 스프레딩 장치, 액체 스프레딩 방법, 액체 스프레딩 시스템 및 조합 장치와 액체 통과 장치
CN114682310B (zh) * 2020-12-31 2023-12-05 深圳市真迈生物科技有限公司 液路系统、测序系统和方法
WO2023055873A1 (en) * 2021-09-30 2023-04-06 Illumina, Inc. Flow cells and related flow cell manifold assemblies and methods

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Also Published As

Publication number Publication date
CA3067426A1 (en) 2019-11-07
WO2019213007A1 (en) 2019-11-07
CN210775375U (zh) 2020-06-16
JP2020533560A (ja) 2020-11-19
KR102401249B1 (ko) 2022-05-24
JP7001716B2 (ja) 2022-01-20
ES2965840T3 (es) 2024-04-17
KR20200023278A (ko) 2020-03-04
SA519410819B1 (ar) 2022-10-30
NZ759550A (en) 2023-06-30
AU2019261940B2 (en) 2021-07-08
TWI714069B (zh) 2020-12-21
CN110441472A (zh) 2019-11-12
IL270849A (en) 2020-01-30
EP3788383B1 (en) 2023-10-04
BR112019025497B1 (pt) 2022-11-16
EP3788383A4 (en) 2022-03-02
CA3067426C (en) 2022-07-19
CN110441472B (zh) 2022-06-07
US11951477B2 (en) 2024-04-09
EP3788383A1 (en) 2021-03-10
RU2748394C1 (ru) 2021-05-25
AU2019261940A1 (en) 2019-12-19
US20190336970A1 (en) 2019-11-07
TW201947226A (zh) 2019-12-16
US20220323955A1 (en) 2022-10-13
BR112019025497A2 (pt) 2020-06-23
US11376584B2 (en) 2022-07-05

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