BR112019023722A2 - Compostos para a prevenção e tratamento de doenças e o uso dos mesmos - Google Patents
Compostos para a prevenção e tratamento de doenças e o uso dos mesmos Download PDFInfo
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- BR112019023722A2 BR112019023722A2 BR112019023722-4A BR112019023722A BR112019023722A2 BR 112019023722 A2 BR112019023722 A2 BR 112019023722A2 BR 112019023722 A BR112019023722 A BR 112019023722A BR 112019023722 A2 BR112019023722 A2 BR 112019023722A2
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- heteroaryl
- naphthyl
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H99/00—Subject matter not provided for in other groups of this subclass
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
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| WO2020117883A1 (en) * | 2018-12-06 | 2020-06-11 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| JP7547345B2 (ja) * | 2018-12-27 | 2024-09-09 | グリコミメティクス， インコーポレイテッド | ガレクチン－３阻害性ｃ－グリコシド |
| EP3947407B1 (en) | 2019-03-26 | 2024-06-12 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| US12269819B2 (en) | 2019-04-10 | 2025-04-08 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| US12404295B2 (en) | 2019-08-09 | 2025-09-02 | Idorsia Pharmaceuticals Ltd | (Hetero)aryl-methyl-thio-beta-D-galactopyranoside derivatives |
| KR102863667B1 (ko) | 2019-08-09 | 2025-09-23 | 이도르시아 파마슈티컬스 리미티드 | (2-아세트아미딜)티오-베타-d-갈락토피라노시드 유도체 |
| MA56883B1 (fr) | 2019-08-15 | 2025-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés de 2-hydroxycycloalcane-1-carbamoyle |
| CN114585619B (zh) | 2019-08-29 | 2024-09-27 | 爱杜西亚药品有限公司 | α-D-吡喃半乳糖苷衍生物 |
| CN115244045A (zh) * | 2019-12-24 | 2022-10-25 | 糖模拟物有限公司 | 抑制半乳凝素-3的c-糖苷酮、醚和醇 |
| US12275720B2 (en) | 2020-05-05 | 2025-04-15 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| WO2021231243A1 (en) | 2020-05-11 | 2021-11-18 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| CN115768768A (zh) | 2020-05-28 | 2023-03-07 | 百时美施贵宝公司 | 半乳凝素-3抑制剂 |
| WO2022073969A1 (en) | 2020-10-06 | 2022-04-14 | Idorsia Pharmaceuticals Ltd | Spiro derivatives of alpha-d-galactopyranosides |
| US12291520B2 (en) | 2020-11-02 | 2025-05-06 | Idorsia Pharmaceuticals Ltd | Galectin-3 inhibiting 2-hydroxycycloalkane-1-carbamoyl derivatives |
| JP7844491B2 (ja) | 2021-02-09 | 2026-04-13 | イドルシア・ファーマシューティカルズ・リミテッド | ヒドロキシヘテロシクロアルカン－カルバモイル誘導体 |
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| DE3812681A1 (de) * | 1988-04-16 | 1989-11-02 | Bayer Ag | Substituierte n-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GB9626450D0 (en) * | 1996-12-20 | 1997-02-05 | Oxford Glycosciences Uk Ltd | Therapeutic compounds |
| SE0100172D0 (sv) | 2001-01-22 | 2001-01-22 | Ulf Nilsson | New inhibitors against galectins |
| US6680306B2 (en) | 2001-06-21 | 2004-01-20 | Glycogenesys, Inc. | Method for enhancing the effectiveness of cancer therapies |
| SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel Galactoside Inhibitors of Galectins |
| SE0401301D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel 3-triazolyl-galactoside inhibitors of galectins |
| GB0501008D0 (en) | 2005-01-18 | 2005-02-23 | Amura Therapeutics Ltd | Method of producing conjugate vaccines |
| US9427449B2 (en) | 2005-08-26 | 2016-08-30 | Econugenics, Inc. | Binding of galectin-3 by low molecular weight pectin |
| AU2007319806A1 (en) | 2006-11-15 | 2008-05-22 | The Brigham And Women's Hospital, Inc. | Therapeutic uses of TIM-3 modulators |
| US8697862B2 (en) | 2008-05-16 | 2014-04-15 | Galecto Biotech Ab | Synthesis of galactoside inhibitors |
| ES2652488T3 (es) * | 2009-04-28 | 2018-02-02 | Galecto Biotech Ab | Nuevos inhibidores de galactósidos de galectinas |
| EA201270316A1 (ru) | 2009-08-25 | 2012-09-28 | БиДжи МЕДИСИН, ИНК. | Галектин-3 и сердечная ресинхронизирующая терапия |
| WO2011095772A2 (en) | 2010-02-04 | 2011-08-11 | Summit Corporation Plc | Novel iminosugar therapeutics |
| CA2794066C (en) | 2012-10-31 | 2017-02-28 | Neil Henderson | Galactoside inhibitor of galectins |
| US9243021B2 (en) | 2012-10-31 | 2016-01-26 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| CA2848711C (en) | 2011-09-16 | 2019-08-06 | Galectin Therapeutics, Inc. | Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease |
| CN104245717B (zh) | 2011-12-28 | 2017-10-24 | 卡莱克汀医疗有限公司 | 用于治疗人类疾病的新型糖类药物的组合物 |
| EP2620443A1 (en) | 2012-01-25 | 2013-07-31 | Galecto Biotech AB | Novel galactoside inhibitors of galectins |
| KR102231732B1 (ko) | 2012-10-10 | 2021-03-23 | 갈렉틴 테라퓨틱스, 인크. | 당뇨병성 신장병증 및 관련 질환의 치료를 위한 갈락토스 갈래의 탄수화물 화합물 |
| IN2015DN02573A (enExample) * | 2012-10-31 | 2015-09-11 | Galecto Biotech Ab | |
| EP2919802A4 (en) | 2012-11-15 | 2016-09-14 | Univ Tufts | METHOD, COMPOSITIONS AND KITS FOR TREATING, MODULATING OR PREVENTING ANGIOGENESIS OR FIBROSIS IN A PATIENT USING A GALECTINE PROTEIN HEMMER |
| EP3125908A4 (en) | 2014-03-10 | 2017-11-15 | La Jolla Pharmaceutical Company | Compositions and methods for treating kidney disorders |
| US20170095496A1 (en) | 2014-04-08 | 2017-04-06 | Galecto Biotech Ab | Galactoside inhibitors for new uses |
| JP6735680B2 (ja) | 2014-07-09 | 2020-08-05 | ガレクト バイオテック エービー | ガレクチンの新規ハイブリッドガラクトシド阻害剤 |
| CA2970062C (en) * | 2015-01-30 | 2023-02-28 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| US10799522B2 (en) | 2015-07-27 | 2020-10-13 | Wayne State University | Compositions and methods relating to galectin detection |
| CA3000924A1 (en) | 2015-11-09 | 2017-05-18 | Galecto Biotech Ab | Novel galactoside inhibitors of galectins |
| US20190367552A1 (en) * | 2016-03-04 | 2019-12-05 | Galectin Sciences, Llc | Selenogalactoside compounds for the prevention and treatment of diseases associated with galectin and the use thereof |
| CA3062649A1 (en) | 2017-05-12 | 2018-11-15 | Galectin Sciences, Llc | Compounds for the treatment of systemic insulin resistance disorders and the use thereof |
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| AU2018265571A1 (en) | 2019-12-05 |
| EP3621973A1 (en) | 2020-03-18 |
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| CN110869378A (zh) | 2020-03-06 |
| JP2020519625A (ja) | 2020-07-02 |
| CA3062648A1 (en) | 2018-11-15 |
| IL270469B1 (en) | 2023-03-01 |
| KR20200016246A (ko) | 2020-02-14 |
| MX392945B (es) | 2025-03-19 |
| US20200155586A1 (en) | 2020-05-21 |
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| IL270469B2 (en) | 2023-07-01 |
| KR102626669B1 (ko) | 2024-01-17 |
| CN110869378B (zh) | 2023-10-13 |
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