BR112019017355A2 - composições e métodos para controle metabólico dinâmico robusto - Google Patents

composições e métodos para controle metabólico dinâmico robusto Download PDF

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Publication number
BR112019017355A2
BR112019017355A2 BR112019017355A BR112019017355A BR112019017355A2 BR 112019017355 A2 BR112019017355 A2 BR 112019017355A2 BR 112019017355 A BR112019017355 A BR 112019017355A BR 112019017355 A BR112019017355 A BR 112019017355A BR 112019017355 A2 BR112019017355 A2 BR 112019017355A2
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Brazil
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compositions
methods
metabolic control
robust dynamic
dynamic metabolic
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BR112019017355A
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English (en)
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David Lynch Michael
Ye Zhixia
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Univ Duke
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
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    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
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    • C12N9/1025—Acyltransferases (2.3)
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
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    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
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  • Life Sciences & Earth Sciences (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract

a presente invenção refere-se a composições e métodos para produção rápida de substâncias químicas em micro-organismos geneticamente engenheirados em uma larga escala. é também provida aqui uma plataforma de engenharia metabólica de alto rendimento que permite a otimização rápida de cepas de produção microbiana. a plataforma, que preenche uma lacuna entre abordagens de bioprodução in vivo e in vitro, se baseia na minimização dinâmica da rede metabólica ativa.
BR112019017355A 2017-02-21 2018-02-21 composições e métodos para controle metabólico dinâmico robusto BR112019017355A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762461436P 2017-02-21 2017-02-21
PCT/US2018/019040 WO2018156646A1 (en) 2017-02-21 2018-02-21 Compositions and methods for robust dynamic metabolic control

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US (7) US11268111B2 (pt)
EP (1) EP3585878A4 (pt)
JP (1) JP6878607B2 (pt)
KR (1) KR102357193B1 (pt)
CN (1) CN110536960B (pt)
AU (2) AU2018224036B2 (pt)
BR (1) BR112019017355A2 (pt)
CA (1) CA3054198A1 (pt)
IL (4) IL305141A (pt)
MY (1) MY193581A (pt)
SG (1) SG11201907685TA (pt)
WO (1) WO2018156646A1 (pt)

Families Citing this family (7)

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JP6730199B2 (ja) 2014-06-11 2020-07-29 デューク ユニバーシティ 合成代謝弁を用いた迅速かつ動的なフラックス制御のための組成物及び方法
IL305141A (en) 2017-02-21 2023-10-01 Univ Duke Preparations and methods for robust dynamic metabolic control
WO2019246488A1 (en) * 2018-06-21 2019-12-26 Duke University Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control
CN110551669B (zh) * 2019-09-05 2022-05-06 江南大学 一种近红外光控制的动态调控系统及其应用
US20220411806A1 (en) * 2019-10-23 2022-12-29 Duke University Compositions, systems, and methods for high level expression of recombinant protein
IL296416A (en) * 2020-03-16 2022-11-01 Univ Duke Methods and compositions for improving type i-e CRISPR-based gene silencing
IL297008A (en) * 2020-04-03 2022-12-01 Univ Duke Methods and compositions for producing xylitol from xylose using dynamic metabolic control

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IL305141A (en) * 2017-02-21 2023-10-01 Univ Duke Preparations and methods for robust dynamic metabolic control

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AU2022224766B2 (en) 2024-05-16
US20200056211A1 (en) 2020-02-20
IL268816A (en) 2019-10-31
IL296347A (en) 2022-11-01
US11339413B2 (en) 2022-05-24
IL268816B1 (en) 2023-10-01
US11193149B2 (en) 2021-12-07
AU2018224036A1 (en) 2019-10-10
KR20190120774A (ko) 2019-10-24
AU2018224036B2 (en) 2022-06-09
IL296347B1 (en) 2023-11-01
MY193581A (en) 2022-10-19
IL305141A (en) 2023-10-01
US20200149075A1 (en) 2020-05-14
CN110536960A (zh) 2019-12-03
IL296347B2 (en) 2024-03-01
EP3585878A4 (en) 2020-12-09
US20240035052A1 (en) 2024-02-01
US20220220514A1 (en) 2022-07-14
IL296348B1 (en) 2023-11-01
WO2018156646A1 (en) 2018-08-30
JP6878607B2 (ja) 2021-05-26
IL268816B2 (en) 2024-02-01
JP2020508050A (ja) 2020-03-19
US11746362B2 (en) 2023-09-05
CA3054198A1 (en) 2018-08-30
IL296348A (en) 2022-11-01
AU2022224766A1 (en) 2022-09-22
US20200248212A1 (en) 2020-08-06
US11268111B2 (en) 2022-03-08
US11279956B2 (en) 2022-03-22
US20200325501A1 (en) 2020-10-15
US11236370B2 (en) 2022-02-01
EP3585878A1 (en) 2020-01-01
IL296348B2 (en) 2024-03-01
SG11201907685TA (en) 2019-09-27
KR102357193B1 (ko) 2022-02-04
CN110536960B (zh) 2024-04-26
US20200248211A1 (en) 2020-08-06

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