BR112019014707A2 - peptídeo mimético apoc-ii isolado, composição farmacêutica, e, métodos para tratar hipertrigliceridemia e para fabricar o peptídeo. - Google Patents

peptídeo mimético apoc-ii isolado, composição farmacêutica, e, métodos para tratar hipertrigliceridemia e para fabricar o peptídeo. Download PDF

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Publication number
BR112019014707A2
BR112019014707A2 BR112019014707A BR112019014707A BR112019014707A2 BR 112019014707 A2 BR112019014707 A2 BR 112019014707A2 BR 112019014707 A BR112019014707 A BR 112019014707A BR 112019014707 A BR112019014707 A BR 112019014707A BR 112019014707 A2 BR112019014707 A2 BR 112019014707A2
Authority
BR
Brazil
Prior art keywords
apoc
peptide according
helix
peptide
amino acid
Prior art date
Application number
BR112019014707A
Other languages
English (en)
Portuguese (pt)
Inventor
Thomas Remaley Alan
Wolska Anna
Lo Chih-Hung
O Sviridov Denis
N Devalaraja Madhav
Shanker Ghosh Soumitra
Original Assignee
Corvidia Therapeutics Inc
The Us Secretary Department Of Health & Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corvidia Therapeutics Inc, The Us Secretary Department Of Health & Human Services filed Critical Corvidia Therapeutics Inc
Publication of BR112019014707A2 publication Critical patent/BR112019014707A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1722Plasma globulins, lactoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
BR112019014707A 2017-01-19 2018-01-19 peptídeo mimético apoc-ii isolado, composição farmacêutica, e, métodos para tratar hipertrigliceridemia e para fabricar o peptídeo. BR112019014707A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762448358P 2017-01-19 2017-01-19
US201762476535P 2017-03-24 2017-03-24
US201762476531P 2017-03-24 2017-03-24
PCT/US2018/014532 WO2018136803A1 (en) 2017-01-19 2018-01-19 Apoc-ii mimetic peptides

Publications (1)

Publication Number Publication Date
BR112019014707A2 true BR112019014707A2 (pt) 2020-04-07

Family

ID=62908746

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019014707A BR112019014707A2 (pt) 2017-01-19 2018-01-19 peptídeo mimético apoc-ii isolado, composição farmacêutica, e, métodos para tratar hipertrigliceridemia e para fabricar o peptídeo.

Country Status (14)

Country Link
US (2) US11136372B2 (enExample)
EP (1) EP3571216A4 (enExample)
JP (2) JP7353973B2 (enExample)
KR (1) KR102700862B1 (enExample)
CN (1) CN110831957B (enExample)
AU (1) AU2018210404B2 (enExample)
BR (1) BR112019014707A2 (enExample)
CA (1) CA3050106A1 (enExample)
IL (2) IL268093B2 (enExample)
MX (1) MX2019008529A (enExample)
NZ (1) NZ755599A (enExample)
SG (2) SG10201911974UA (enExample)
TW (2) TW202130652A (enExample)
WO (1) WO2018136803A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019008529A (es) 2017-01-19 2020-02-07 Us Health Peptidos mimeticos de apolipoproteina c-ii (apoc-ii).
US20240309065A1 (en) * 2021-06-23 2024-09-19 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Short apoc-ii mimetic peptides and methods of use
US20250304622A1 (en) * 2022-05-05 2025-10-02 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Short apolipoprotein e mimetic peptides and methods of use
WO2024036145A1 (en) * 2022-08-07 2024-02-15 Protean Bio, Inc. Peptides for beta-cell survival and insulin production

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
WO1998009602A2 (en) * 1996-09-05 1998-03-12 The Uab Research Foundation Anti-atherosclerotic peptides and a transgenic mouse model of atherosclerosis
CA2460787A1 (en) 2001-09-28 2003-04-03 Esperion Therapeutics, Inc. Prevention and treatment of restenosis by local administration of drug
US7220576B2 (en) * 2002-01-07 2007-05-22 Lifesensors, Inc. Methods and compositions for protein expression and purification
US7691965B2 (en) * 2002-05-08 2010-04-06 The Regents Of The University Of California Helical synthetic peptides that stimulate cellular cholesterol efflux
JP2007504285A (ja) * 2003-01-17 2007-03-01 メルク エンド カムパニー インコーポレーテッド N−シクロヘキシルアミノカルボニルベンゼンスルホンアミド誘導体
CA2555409A1 (en) * 2004-02-19 2005-09-01 Banyu Pharmaceutical Co., Ltd. Novel sulfone amide derivative
EP1771473B1 (en) 2004-07-16 2012-12-26 Trustees Of Tufts College Apolipoprotein a1 mimetics and uses thereof
JP5143729B2 (ja) * 2005-06-29 2013-02-13 ハダジット メディカル リサーチ サービシズ アンド ディベラップメント リミテッド インスリン抵抗性及び2型糖尿病の予防のためのプロテインキナーゼc阻害剤
WO2008039843A2 (en) * 2006-09-26 2008-04-03 Lipid Sciences, Inc. Novel peptides that promote lipid efflux
WO2009097584A1 (en) 2008-01-30 2009-08-06 Proteogenix, Inc. Maternal serum biomarkers for detection of pre-eclampsia
WO2009129263A1 (en) * 2008-04-15 2009-10-22 The Government Of The Usa As Represented By The Secretary Of The Department Of Health & Human Serv. Peptides promoting lipid efflux via abca1 and activating a lipoprotein lipase
CN102753576A (zh) * 2009-09-30 2012-10-24 首尔大学教产学协力团 载脂蛋白a-1模拟肽以及包含其的用于治疗高血脂及高血脂相关疾病的治疗剂
CA2888657C (en) 2012-11-06 2022-05-03 Les Hopitaux Universitaires De Geneve Mimetic peptides
MX2019008529A (es) 2017-01-19 2020-02-07 Us Health Peptidos mimeticos de apolipoproteina c-ii (apoc-ii).
EA201991491A1 (ru) 2017-03-24 2019-12-30 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сервисис Миметические пептиды apoc-ii

Also Published As

Publication number Publication date
KR102700862B1 (ko) 2024-08-30
IL268093B2 (en) 2024-07-01
JP2023116739A (ja) 2023-08-22
JP2020511425A (ja) 2020-04-16
AU2018210404B2 (en) 2022-01-27
US11827690B2 (en) 2023-11-28
US20210324043A1 (en) 2021-10-21
NZ755599A (en) 2022-12-23
CA3050106A1 (en) 2018-07-26
SG11201906422VA (en) 2019-08-27
TWI788323B (zh) 2023-01-01
US11136372B2 (en) 2021-10-05
KR20190121305A (ko) 2019-10-25
IL268093A (en) 2019-09-26
EP3571216A1 (en) 2019-11-27
SG10201911974UA (en) 2020-02-27
TW201835097A (zh) 2018-10-01
TW202130652A (zh) 2021-08-16
AU2018210404A1 (en) 2019-08-08
WO2018136803A8 (en) 2019-08-01
US20200140522A1 (en) 2020-05-07
MX2019008529A (es) 2020-02-07
WO2018136803A1 (en) 2018-07-26
CN110831957B (zh) 2024-02-09
JP7353973B2 (ja) 2023-10-02
CN110831957A (zh) 2020-02-21
IL268093B1 (en) 2024-03-01
IL279831A (en) 2021-03-01
EP3571216A4 (en) 2020-11-04

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25A Requested transfer of rights approved

Owner name: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) ; NOVO NORDISK A/S (DK)

B25G Requested change of headquarter approved

Owner name: NOVO NORDISK A/S (DK) ; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US)

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]