BR112019003661A2 - uso de derivados de triazolo(4,5-d)pirimidina para prevenção e tratamento de infecção bacteriana - Google Patents
uso de derivados de triazolo(4,5-d)pirimidina para prevenção e tratamento de infecção bacterianaInfo
- Publication number
- BR112019003661A2 BR112019003661A2 BR112019003661-0A BR112019003661A BR112019003661A2 BR 112019003661 A2 BR112019003661 A2 BR 112019003661A2 BR 112019003661 A BR112019003661 A BR 112019003661A BR 112019003661 A2 BR112019003661 A2 BR 112019003661A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- triazolo
- prevention
- bacterial infection
- pyrimidine derivatives
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000032770 biofilm formation Effects 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 210000003709 heart valve Anatomy 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
derivados de triazolo(4,5-d)pirimidina para uso no tratamento ou prevenção de infecção bacteriana em um mamífero hospedeiro com necessidade de tal tratamento ou uso como inibidor da formação de biofilme sobre uma superfície de biomaterial ou dispositivo médico, particularmente do dispositivo cardiovascular tal como a prótese valvar cardíaca ou marca-passos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16188201.4A EP3292867B1 (en) | 2016-09-09 | 2016-09-09 | Triazolo(4,5-d)pyrimidine derivatives for use in the prevention and treatment of bacterial infection |
EP16188201.4 | 2016-09-09 | ||
PCT/EP2017/068811 WO2018046174A1 (en) | 2016-09-09 | 2017-07-25 | New use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019003661A2 true BR112019003661A2 (pt) | 2019-05-21 |
Family
ID=56896425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019003661-0A BR112019003661A2 (pt) | 2016-09-09 | 2017-07-25 | uso de derivados de triazolo(4,5-d)pirimidina para prevenção e tratamento de infecção bacteriana |
Country Status (11)
Country | Link |
---|---|
US (1) | US20190194213A1 (pt) |
EP (2) | EP3292867B1 (pt) |
JP (1) | JP7075667B2 (pt) |
KR (1) | KR102401152B1 (pt) |
CN (1) | CN109689061B (pt) |
AU (1) | AU2017324655B2 (pt) |
BR (1) | BR112019003661A2 (pt) |
CA (1) | CA3035686C (pt) |
DK (2) | DK3292867T3 (pt) |
ES (2) | ES2731658T3 (pt) |
WO (1) | WO2018046174A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3527571A1 (en) * | 2018-02-14 | 2019-08-21 | Université de Liège | Pyrimidine derivatives for prevention and treatment of bacterial infection |
EP3955929B1 (en) * | 2019-04-18 | 2024-05-15 | Université de Liège | New pyrimidine derivatives for prevention and treatment of gram-negative bacterial infection, contamination and fouling |
GB201910656D0 (en) * | 2019-07-25 | 2019-09-11 | Univ Liege | New use of triazolo(4,5-d)Pyrimidine deerivatives |
EP4298151A1 (en) | 2021-02-26 | 2024-01-03 | Université de Liège | New antimicrobial and antithrombogenic medical device |
WO2023213198A1 (zh) * | 2022-05-04 | 2023-11-09 | 华东师范大学 | 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂 |
EP4289435A1 (en) | 2022-06-07 | 2023-12-13 | Université de Liège | N-alkyl-2-substituted atp analogues for use as antibacterial agent |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9702773D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
TWI229674B (en) * | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
WO2009034386A1 (en) * | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
US8802850B2 (en) * | 2009-07-27 | 2014-08-12 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of P2Y12 receptor |
KR20120123659A (ko) * | 2009-12-03 | 2012-11-09 | 아스트라제네카 아베 | 트리아졸로[4,5-d]피리미딘 혈소판 응집 억제제의 공결정 |
CA2836394A1 (en) * | 2011-06-01 | 2012-12-06 | Astrazeneca Ab | Novel ticagrelor co - crystal |
WO2013092900A1 (en) * | 2011-12-23 | 2013-06-27 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
US9233966B2 (en) * | 2012-04-05 | 2016-01-12 | Dr. Reddy's Laboratories Limited | Preparation of ticagrelor |
EP2867235A1 (en) * | 2012-06-29 | 2015-05-06 | Zentiva K.S. | Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl)cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol |
CN104640864B (zh) * | 2012-07-04 | 2016-11-16 | 力奇制药公司 | 替格瑞洛与二价金属盐的加合物 |
CN104341423B (zh) * | 2013-08-02 | 2017-03-01 | 上海京新生物医药有限公司 | 替格瑞洛的一水合物及其制备方法与在制药中的应用 |
WO2015162537A1 (en) * | 2014-04-23 | 2015-10-29 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of ticagrelor |
WO2016116942A1 (en) * | 2015-01-20 | 2016-07-28 | Anlon Chemical Research Organization | Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin |
-
2016
- 2016-09-09 ES ES16188201T patent/ES2731658T3/es active Active
- 2016-09-09 EP EP16188201.4A patent/EP3292867B1/en not_active Not-in-force
- 2016-09-09 DK DK16188201.4T patent/DK3292867T3/da active
-
2017
- 2017-07-25 DK DK17743050.1T patent/DK3509598T3/da active
- 2017-07-25 ES ES17743050T patent/ES2841742T3/es active Active
- 2017-07-25 BR BR112019003661-0A patent/BR112019003661A2/pt active Search and Examination
- 2017-07-25 US US16/331,920 patent/US20190194213A1/en not_active Abandoned
- 2017-07-25 CN CN201780054753.2A patent/CN109689061B/zh active Active
- 2017-07-25 JP JP2019513341A patent/JP7075667B2/ja active Active
- 2017-07-25 KR KR1020197008453A patent/KR102401152B1/ko active IP Right Grant
- 2017-07-25 AU AU2017324655A patent/AU2017324655B2/en active Active
- 2017-07-25 WO PCT/EP2017/068811 patent/WO2018046174A1/en unknown
- 2017-07-25 CA CA3035686A patent/CA3035686C/en active Active
- 2017-07-25 EP EP17743050.1A patent/EP3509598B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR102401152B1 (ko) | 2022-05-24 |
DK3509598T3 (da) | 2020-12-21 |
CA3035686C (en) | 2023-07-25 |
EP3509598B1 (en) | 2020-10-07 |
AU2017324655A1 (en) | 2019-03-07 |
US20190194213A1 (en) | 2019-06-27 |
CN109689061B (zh) | 2023-03-31 |
EP3509598A1 (en) | 2019-07-17 |
DK3292867T3 (da) | 2019-07-22 |
JP7075667B2 (ja) | 2022-05-26 |
EP3292867B1 (en) | 2019-05-15 |
ES2841742T3 (es) | 2021-07-09 |
CA3035686A1 (en) | 2018-03-15 |
WO2018046174A1 (en) | 2018-03-15 |
AU2017324655B2 (en) | 2021-04-29 |
ES2731658T3 (es) | 2019-11-18 |
KR20190045237A (ko) | 2019-05-02 |
JP2019529398A (ja) | 2019-10-17 |
CN109689061A (zh) | 2019-04-26 |
EP3292867A1 (en) | 2018-03-14 |
NZ751185A (en) | 2023-10-27 |
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] |