BR112018073549A2 - tratamento de lesões de pele - Google Patents

tratamento de lesões de pele

Info

Publication number
BR112018073549A2
BR112018073549A2 BR112018073549-3A BR112018073549A BR112018073549A2 BR 112018073549 A2 BR112018073549 A2 BR 112018073549A2 BR 112018073549 A BR112018073549 A BR 112018073549A BR 112018073549 A2 BR112018073549 A2 BR 112018073549A2
Authority
BR
Brazil
Prior art keywords
skin injury
injury treatment
formula
treatment
tautomers
Prior art date
Application number
BR112018073549-3A
Other languages
English (en)
Other versions
BR112018073549A8 (pt
Inventor
Fabbro Doriano
Hebeisen Paul
Hillmann-Wuellner Petra
Stuetz Anton
T. Seykora John
Beaufils Florent
Original Assignee
Piqur Therapeutics Ag
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piqur Therapeutics Ag, The Trustees Of The University Of Pennsylvania filed Critical Piqur Therapeutics Ag
Priority claimed from PCT/EP2017/025137 external-priority patent/WO2017198347A1/en
Publication of BR112018073549A2 publication Critical patent/BR112018073549A2/pt
Publication of BR112018073549A8 publication Critical patent/BR112018073549A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

a presente invenção refere-se a um composto da fórmula (i), (i) com a condição de que pelo menos um dentre r1 e r2 é uma morfolinila de fórmula ii; (ii) e profármacos, metabólitos, tautômeros, solvatos e sais farmaceuticamente aceitáveis dos mesmos, para uso na prevenção ou no tratamento de uma lesão de pele em um sujeito.
BR112018073549A 2016-05-18 2017-05-17 Uso de inibidores seletivos e específicos de mtor e/ou de inibidores duplos de pi3k/mtor, e composição farmacêutica BR112018073549A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662338111P 2016-05-18 2016-05-18
US62/338,111 2016-05-18
EP17151843 2017-01-17
EP17151843.4 2017-01-17
PCT/EP2017/025137 WO2017198347A1 (en) 2016-05-18 2017-05-17 Treatment of skin lesions

Publications (2)

Publication Number Publication Date
BR112018073549A2 true BR112018073549A2 (pt) 2019-03-19
BR112018073549A8 BR112018073549A8 (pt) 2023-01-10

Family

ID=65463390

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018073549A BR112018073549A8 (pt) 2016-05-18 2017-05-17 Uso de inibidores seletivos e específicos de mtor e/ou de inibidores duplos de pi3k/mtor, e composição farmacêutica

Country Status (9)

Country Link
US (2) US10993947B2 (pt)
JP (3) JP7118509B2 (pt)
KR (1) KR102483630B1 (pt)
CN (1) CN109414415B (pt)
BR (1) BR112018073549A8 (pt)
IL (1) IL263076B (pt)
MX (1) MX2018014167A (pt)
RU (1) RU2018140001A (pt)
ZA (1) ZA201807325B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018014168A (es) * 2016-05-18 2019-04-29 Piqur Therapeutics Ag Tratamiento de transtornos neurologicos.
IL274132B2 (en) * 2017-11-23 2024-02-01 Piqur Therapeutics Ag Treatment of skin problems

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
MX2008010221A (es) 2006-02-09 2009-03-05 Alba Therapeutics Corp Formulaciones para un efector de union ajustada.
ATE551334T1 (de) 2007-02-06 2012-04-15 Novartis Ag Pi3-kinase-hemmer und verfahren zu ihrer verwendung
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
WO2012099968A1 (en) * 2011-01-19 2012-07-26 The Trustees Of The University Of Pennsylvania Compositions and methods for treating skin cancer associated diseases
WO2012101654A2 (en) 2011-01-25 2012-08-02 Sphaera Pharma Pvt. Ltd Novel triazine compounds
JP2014505107A (ja) * 2011-02-11 2014-02-27 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 過誤腫性腫瘍細胞を阻害する方法
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
WO2014090147A1 (zh) * 2012-12-14 2014-06-19 上海恒瑞医药有限公司 嘧啶类衍生物及其可药用盐、其制备方法及其在医药上的应用
US20150065431A1 (en) 2013-08-27 2015-03-05 Northwestern University Reducing cutaneous scar formation and treating skin conditions
CN103483345B (zh) * 2013-09-25 2016-07-06 中山大学 Pi3k激酶抑制剂、包含其的药物组合物及其应用
CN104557871B (zh) * 2013-10-28 2017-05-03 上海汇伦生命科技有限公司 具有螺环取代基的芳基吗啉类化合物，其制备方法和用途
AU2015250994B2 (en) 2014-04-22 2018-12-20 Torqur Ag Novel manufacturing process for triazine, pyrimidine and pyridine derivatives
AU2015266191A1 (en) 2014-05-27 2016-09-15 Almirall, S.A. Medical use
CA2953392A1 (en) * 2014-06-30 2016-01-07 Baxter Corporation Englewood Managed medical information exchange
MA40933A (fr) * 2014-11-11 2017-09-19 Piqur Therapeutics Ag Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
MX2018014168A (es) 2016-05-18 2019-04-29 Piqur Therapeutics Ag Tratamiento de transtornos neurologicos.

Also Published As

Publication number Publication date
KR102483630B1 (ko) 2023-01-02
RU2018140001A (ru) 2020-06-18
CN109414415A (zh) 2019-03-01
JP2019515020A (ja) 2019-06-06
US10993947B2 (en) 2021-05-04
MX2018014167A (es) 2019-08-16
CN109414415B (zh) 2023-05-02
US11918586B2 (en) 2024-03-05
JP7118509B2 (ja) 2022-08-16
JP7464645B2 (ja) 2024-04-09
IL263076B (en) 2022-02-01
JP2024050600A (ja) 2024-04-10
JP2022088520A (ja) 2022-06-14
KR20190026668A (ko) 2019-03-13
US20210361665A1 (en) 2021-11-25
ZA201807325B (en) 2019-08-28
BR112018073549A8 (pt) 2023-01-10
US20190290653A1 (en) 2019-09-26
IL263076A (en) 2018-12-31
RU2018140001A3 (pt) 2020-08-21

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25A Requested transfer of rights approved

Owner name: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) ; TORQUR AG (CH)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]