BR112018073368A2 - sal farmaceuticamente aceitável como inibidor de canal de potássio da medula renal externa - Google Patents

sal farmaceuticamente aceitável como inibidor de canal de potássio da medula renal externa

Info

Publication number
BR112018073368A2
BR112018073368A2 BR112018073368-7A BR112018073368A BR112018073368A2 BR 112018073368 A2 BR112018073368 A2 BR 112018073368A2 BR 112018073368 A BR112018073368 A BR 112018073368A BR 112018073368 A2 BR112018073368 A2 BR 112018073368A2
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
acceptable salt
potassium channel
channel inhibitor
marrow
Prior art date
Application number
BR112018073368-7A
Other languages
English (en)
Inventor
Lu Yun
Shao Qiyun
Wu Guaili
Feng Jun
Original Assignee
Jiangsu Hengrui Medicine Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co., Ltd. filed Critical Jiangsu Hengrui Medicine Co., Ltd.
Publication of BR112018073368A2 publication Critical patent/BR112018073368A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

é fornecido um sal farmaceuticamente aceitável como um inibidor do canal de potássio da medula renal externa (romk), especificamente um l-tartarato e uma forma cristalina i e forma cristalina ii do mesmo. o sal farmaceuticamente aceitável do inibidor de romk, especificamente o l-tartarato, melhorou a biodisponibilidade e a estabilidade.
BR112018073368-7A 2016-06-07 2017-06-06 sal farmaceuticamente aceitável como inibidor de canal de potássio da medula renal externa BR112018073368A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610398233 2016-06-07
CN201610398233.0 2016-06-07
PCT/CN2017/087326 WO2017211271A1 (zh) 2016-06-07 2017-06-06 一种肾外髓质分泌钾通道抑制剂的可药用盐

Publications (1)

Publication Number Publication Date
BR112018073368A2 true BR112018073368A2 (pt) 2019-03-06

Family

ID=60577585

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018073368-7A BR112018073368A2 (pt) 2016-06-07 2017-06-06 sal farmaceuticamente aceitável como inibidor de canal de potássio da medula renal externa

Country Status (11)

Country Link
US (1) US11059810B2 (pt)
EP (1) EP3466945A4 (pt)
JP (1) JP2019517494A (pt)
KR (1) KR20190015305A (pt)
CN (1) CN108290874B (pt)
AU (1) AU2017277002B2 (pt)
BR (1) BR112018073368A2 (pt)
CA (1) CA3024727A1 (pt)
MX (1) MX2018014759A (pt)
TW (1) TW201742866A (pt)
WO (1) WO2017211271A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109879863B (zh) * 2017-12-06 2020-10-20 江苏恒瑞医药股份有限公司 一种肾外髓质分泌钾通道抑制剂的晶型及其制备方法
CN111372929B (zh) * 2017-12-06 2022-04-12 江苏恒瑞医药股份有限公司 一种肾外髓质分泌钾通道抑制剂的晶型及其制备方法
TW202045170A (zh) * 2019-02-28 2020-12-16 大陸商江蘇恒瑞醫藥股份有限公司 一種含有腎臟鉀離子外排通道抑制劑的藥物組合物及其製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
JP2014101353A (ja) * 2012-10-26 2014-06-05 Shionogi & Co Ltd オキサジン誘導体を含有するアルツハイマー症治療用または予防用医薬組成物
EP2925322B1 (en) * 2012-11-29 2018-10-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9951052B2 (en) * 2013-10-31 2018-04-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CA2966788A1 (en) * 2014-12-08 2016-06-16 Shanghai Hengrui Pharmaceutical Co., Ltd. Pyridinecarboxamide derivatives, preparation method therefor and pharmaceutical uses thereof

Also Published As

Publication number Publication date
CN108290874B (zh) 2021-07-27
TW201742866A (zh) 2017-12-16
WO2017211271A1 (zh) 2017-12-14
JP2019517494A (ja) 2019-06-24
AU2017277002A1 (en) 2018-11-22
MX2018014759A (es) 2019-03-11
EP3466945A1 (en) 2019-04-10
US11059810B2 (en) 2021-07-13
EP3466945A4 (en) 2019-11-06
AU2017277002B2 (en) 2021-01-21
CN108290874A (zh) 2018-07-17
KR20190015305A (ko) 2019-02-13
US20200123135A1 (en) 2020-04-23
CA3024727A1 (en) 2017-12-14

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements