BR112018072248A2 - composições e métodos relacionados a imunógenos contra hiv-1 - Google Patents
composições e métodos relacionados a imunógenos contra hiv-1Info
- Publication number
- BR112018072248A2 BR112018072248A2 BR112018072248-0A BR112018072248A BR112018072248A2 BR 112018072248 A2 BR112018072248 A2 BR 112018072248A2 BR 112018072248 A BR112018072248 A BR 112018072248A BR 112018072248 A2 BR112018072248 A2 BR 112018072248A2
- Authority
- BR
- Brazil
- Prior art keywords
- immunogens
- hiv
- compositions
- methods related
- vaccine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
- C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Nanotechnology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330604P | 2016-05-02 | 2016-05-02 | |
| US62/330,604 | 2016-05-02 | ||
| PCT/US2017/030375 WO2017192434A1 (en) | 2016-05-02 | 2017-05-01 | Compositions and methods related to hiv-1 immunogens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018072248A2 true BR112018072248A2 (pt) | 2019-02-12 |
Family
ID=60203504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018072248-0A BR112018072248A2 (pt) | 2016-05-02 | 2017-05-01 | composições e métodos relacionados a imunógenos contra hiv-1 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US10647748B2 (https=) |
| EP (1) | EP3452494A4 (https=) |
| JP (1) | JP7046832B2 (https=) |
| CN (1) | CN109153704A (https=) |
| AU (2) | AU2017259275C1 (https=) |
| BR (1) | BR112018072248A2 (https=) |
| CA (1) | CA3022826A1 (https=) |
| EA (1) | EA201892233A1 (https=) |
| IL (2) | IL299962A (https=) |
| MX (1) | MX2018013455A (https=) |
| SG (1) | SG11201809387QA (https=) |
| WO (1) | WO2017192434A1 (https=) |
| ZA (1) | ZA201807216B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11572389B2 (en) * | 2017-01-27 | 2023-02-07 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Vaccine compositions of herpesvirus envelope protein combinations to induce immune response |
| CN112469661B (zh) * | 2018-06-13 | 2024-04-26 | 斯克里普斯研究学院 | 具有新结构组分的纳米粒疫苗 |
| WO2020117760A1 (en) * | 2018-12-03 | 2020-06-11 | Duke University | Purification method for recombinant proteins and nanoparticles |
| AU2020323462A1 (en) * | 2019-07-26 | 2022-03-10 | The Scripps Research Institute | Engineered HCV E2 immunogens and related vaccine compositions |
| EP4051318A4 (en) * | 2019-10-29 | 2023-10-11 | International AIDS Vaccine Initiative | ENGINEERED ANTI-ENV HIV ANTIBODIES |
| JP7170942B1 (ja) * | 2019-11-07 | 2022-11-14 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | タンパク質精製 |
| CN111647078B (zh) * | 2020-06-22 | 2022-04-26 | 中国医学科学院医学生物学研究所 | 一种抗hiv的单克隆抗体及其制备方法和应用 |
| US10906944B2 (en) | 2020-06-29 | 2021-02-02 | The Scripps Research Institute | Stabilized coronavirus spike (S) protein immunogens and related vaccines |
| WO2022100703A1 (zh) * | 2020-11-12 | 2022-05-19 | 厦门大学 | 经改造的人免疫缺陷病毒膜蛋白及其应用 |
| CN116769053B (zh) * | 2023-05-26 | 2023-12-15 | 华中农业大学 | 重组AaLS-BPP融合肽、制备方法及应用 |
| CN121293297A (zh) * | 2025-12-04 | 2026-01-09 | 广州千扬生物医药技术有限公司 | 一种hiv纳米颗粒疫苗 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU698962B2 (en) | 1993-09-14 | 1998-11-12 | Epimmune, Inc. | Alteration of immune response using pan DR-binding peptides |
| US7550143B2 (en) | 2005-04-06 | 2009-06-23 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| WO2008063331A2 (en) * | 2006-10-23 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | Modified gp140 envelope polypeptides of hiv-1 isolates, compositions, stabilized trimeric complexes, and uses thereof |
| JP2011502521A (ja) * | 2007-11-12 | 2011-01-27 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | Ｈｉｖ−１外被糖タンパク質オリゴマー及び使用方法 |
| RU2540871C2 (ru) | 2008-02-01 | 2015-02-10 | Альфа-О Пептидес Аг | Самоорганизующиеся пептидные наночастицы, полезные в качестве вакцин |
| EP2765138B1 (en) * | 2012-11-05 | 2018-01-10 | International Aids Vaccine Initiative | HIV-1 envelope glycoprotein |
| AP2015008634A0 (en) | 2013-01-07 | 2015-07-31 | Beth Israel Hospital | Stabilized human immunodeficiency virus 'hiv' env elope 'env' trimer vaccines and methods of using same |
| WO2016037154A1 (en) * | 2014-09-04 | 2016-03-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Recombinant hiv-1 envelope proteins and their use |
| US10501733B2 (en) | 2015-02-27 | 2019-12-10 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| AR109528A1 (es) * | 2016-09-15 | 2018-12-19 | Janssen Vaccines & Prevention Bv | Mutaciones estabilizantes de trímeros de proteínas de la envoltura del vih |
-
2017
- 2017-05-01 SG SG11201809387QA patent/SG11201809387QA/en unknown
- 2017-05-01 IL IL299962A patent/IL299962A/en unknown
- 2017-05-01 CA CA3022826A patent/CA3022826A1/en active Pending
- 2017-05-01 CN CN201780027483.6A patent/CN109153704A/zh active Pending
- 2017-05-01 MX MX2018013455A patent/MX2018013455A/es unknown
- 2017-05-01 BR BR112018072248-0A patent/BR112018072248A2/pt active IP Right Grant
- 2017-05-01 WO PCT/US2017/030375 patent/WO2017192434A1/en not_active Ceased
- 2017-05-01 AU AU2017259275A patent/AU2017259275C1/en active Active
- 2017-05-01 EA EA201892233A patent/EA201892233A1/ru unknown
- 2017-05-01 EP EP17793064.1A patent/EP3452494A4/en active Pending
- 2017-05-01 JP JP2018557105A patent/JP7046832B2/ja active Active
-
2018
- 2018-10-24 IL IL262582A patent/IL262582B2/en unknown
- 2018-10-29 ZA ZA2018/07216A patent/ZA201807216B/en unknown
- 2018-10-31 US US16/176,200 patent/US10647748B2/en active Active
-
2020
- 2020-02-03 US US16/780,495 patent/US11236134B2/en active Active
-
2021
- 2021-08-25 AU AU2021221582A patent/AU2021221582B2/en active Active
- 2021-12-16 US US17/553,070 patent/US11767347B2/en active Active
-
2023
- 2023-08-15 US US18/449,739 patent/US20240083954A1/en not_active Abandoned
-
2024
- 2024-08-28 US US18/817,389 patent/US20250122247A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017259275A1 (en) | 2018-11-15 |
| IL262582B2 (en) | 2023-06-01 |
| JP7046832B2 (ja) | 2022-04-04 |
| IL299962A (en) | 2023-03-01 |
| US20240083954A1 (en) | 2024-03-14 |
| MX2018013455A (es) | 2019-02-28 |
| US20190048043A1 (en) | 2019-02-14 |
| US20200165303A1 (en) | 2020-05-28 |
| CN109153704A (zh) | 2019-01-04 |
| SG11201809387QA (en) | 2018-11-29 |
| WO2017192434A1 (en) | 2017-11-09 |
| ZA201807216B (en) | 2020-01-29 |
| US11767347B2 (en) | 2023-09-26 |
| IL262582A (en) | 2018-12-31 |
| EA201892233A1 (ru) | 2019-07-31 |
| US20250122247A1 (en) | 2025-04-17 |
| US20220098244A1 (en) | 2022-03-31 |
| EP3452494A1 (en) | 2019-03-13 |
| US11236134B2 (en) | 2022-02-01 |
| US10647748B2 (en) | 2020-05-12 |
| JP2019522626A (ja) | 2019-08-15 |
| CA3022826A1 (en) | 2017-11-09 |
| AU2021221582A1 (en) | 2021-10-07 |
| AU2017259275C1 (en) | 2022-01-27 |
| EP3452494A4 (en) | 2020-01-01 |
| AU2021221582B2 (en) | 2022-10-20 |
| AU2017259275B2 (en) | 2021-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/05/2017, OBSERVADAS AS CONDICOES LEGAIS |