BR112018015369A2 - composição farmacêutica contendo inibidor de jak cinase ou sal farmaceuticamente aceitável do mesmo - Google Patents

composição farmacêutica contendo inibidor de jak cinase ou sal farmaceuticamente aceitável do mesmo

Info

Publication number
BR112018015369A2
BR112018015369A2 BR112018015369-9A BR112018015369A BR112018015369A2 BR 112018015369 A2 BR112018015369 A2 BR 112018015369A2 BR 112018015369 A BR112018015369 A BR 112018015369A BR 112018015369 A2 BR112018015369 A2 BR 112018015369A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
pharmaceutically acceptable
acceptable salt
composition containing
kinase inhibitor
Prior art date
Application number
BR112018015369-9A
Other languages
English (en)
Chinese (zh)
Inventor
Lu Yun
Chen Hao
Pan Xiaochen
Original Assignee
Jiangsu Hengrui Medicine Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co., Ltd. filed Critical Jiangsu Hengrui Medicine Co., Ltd.
Publication of BR112018015369A2 publication Critical patent/BR112018015369A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção refere-se a uma composição farmacêutica contendo inibidor de jak cinase ou sal farmaceuticamente aceitável do mesmo. em particular, fornecida na presente invenção é uma composição farmacêutica contendo (3ar, 5s, 6as)-n-(3-metóxi-1,2,4-tiadiazol-5-il)-5-(metil(7h-pirrolo[2,3-d]pirimidin-4-il)amino) hexa-hidrociclopenta[c]pirrol-2(1h)-carboxamida, ou um sal farmaceuticamente aceitável do mesmo, e éter de celulose. a composição farmacêutica da presente invenção é caracterizada por taxa de dissolução rápida e boa estabilidade.
BR112018015369-9A 2016-02-19 2017-02-17 composição farmacêutica contendo inibidor de jak cinase ou sal farmaceuticamente aceitável do mesmo BR112018015369A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610094168 2016-02-19
CN201610094168.2 2016-02-19
PCT/CN2017/073869 WO2017140254A1 (zh) 2016-02-19 2017-02-17 一种含有jak激酶抑制剂或其可药用盐的药物组合物

Publications (1)

Publication Number Publication Date
BR112018015369A2 true BR112018015369A2 (pt) 2018-12-18

Family

ID=59624719

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018015369-9A BR112018015369A2 (pt) 2016-02-19 2017-02-17 composição farmacêutica contendo inibidor de jak cinase ou sal farmaceuticamente aceitável do mesmo

Country Status (13)

Country Link
US (1) US10786507B2 (pt)
EP (1) EP3417861B1 (pt)
JP (1) JP6875407B2 (pt)
KR (1) KR20180109992A (pt)
CN (1) CN107530348B (pt)
AU (1) AU2017220971A1 (pt)
BR (1) BR112018015369A2 (pt)
CA (1) CA3014090A1 (pt)
HK (1) HK1244704A1 (pt)
MX (1) MX2018009741A (pt)
RU (1) RU2744432C2 (pt)
TW (1) TWI745349B (pt)
WO (1) WO2017140254A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI760356B (zh) 2016-08-16 2022-04-11 英屬開曼群島商百濟神州有限公司 (ｓ)-７-(１-丙烯醯基六氫吡啶-４-基)-２-(４-苯氧基苯基)-４,５,６,７-四氫吡唑並［１，５-ａ]嘧啶-３-甲醯胺的晶型、其製備和用途
TW201827436A (zh) * 2017-01-20 2018-08-01 大陸商江蘇恆瑞醫藥股份有限公司 一種ｊａｋ激酶抑制劑的硫酸氫鹽的晶型及其製備方法
CN111205290B (zh) * 2018-11-22 2021-10-08 江苏恒瑞医药股份有限公司 一种jak激酶抑制剂的结晶形式及其制备方法
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP3981399A4 (en) * 2019-06-10 2023-05-31 BeiGene Switzerland GmbH ORAL SOLID TABLET WITH A TYROSINE KINAS INHIBITOR AND METHOD OF MANUFACTURE THEREOF
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
BR112022012363A2 (pt) * 2019-12-23 2022-08-30 Jiangsu Hengrui Medicine Co Composições farmacêuticas compreendendo um inibidor de jak quinase, método para preparar e uso das mesmas
MX2022006873A (es) * 2019-12-31 2022-08-18 Pfizer R&D Uk Ltd Formulaciones de capsulas y tabletas de liberacion inmediata estables de 1-((2s,5r)-5-((7h-pirrolo[2,3-d]pirimidin-4-il)amino)- 2-metilpiperidin-1-il)prop-2-en-1-ona.
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
IL300006A (en) 2020-07-28 2023-03-01 Arcutis Biotherapeutics Inc A formulation for external use containing a JAK inhibitor and Orat-4
JP2023550363A (ja) 2020-11-17 2023-12-01 アーキュティス・バイオセラピューティクス・インコーポレーテッド 深部皮膚薬物送達のための組成物および方法
WO2022117075A1 (zh) * 2020-12-04 2022-06-09 广州费米子科技有限责任公司 氮杂并环化合物、其制备方法及其用途
CN113813228B (zh) * 2021-10-11 2023-04-18 北京鑫开元医药科技有限公司 一种具有jak激酶抑制活性的注射液及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3753B1 (ar) * 2011-10-14 2021-01-31 Otsuka Pharma Co Ltd قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه
SI2796460T1 (sl) * 2011-12-21 2018-10-30 Jiangsu Hengrui Medicine Co. Ltd Pirolni šestčlenski derivat heteroarilnega obroča, postopek priprave zanj in medicinske uporabe le-tega
JP6323885B2 (ja) * 2013-06-07 2018-05-16 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． ヤヌスキナーゼ（ｊａｋ）阻害剤の硫酸水素塩およびその製造方法
CN105566327A (zh) 2014-10-09 2016-05-11 江苏恒瑞医药股份有限公司 一种jak激酶抑制剂的硫酸氢盐的i型结晶及其制备方法
KR102522895B1 (ko) 2014-11-05 2023-04-17 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Jak 키나아제 억제제 바이설페이트의 결정형 및 이의 제조방법

Also Published As

Publication number Publication date
WO2017140254A1 (zh) 2017-08-24
EP3417861A4 (en) 2019-09-18
TWI745349B (zh) 2021-11-11
AU2017220971A1 (en) 2018-08-02
JP6875407B2 (ja) 2021-05-26
HK1244704A1 (zh) 2018-08-17
RU2018129775A3 (pt) 2020-05-25
TW201729812A (zh) 2017-09-01
RU2018129775A (ru) 2020-03-19
CA3014090A1 (en) 2017-08-24
CN107530348B (zh) 2020-10-20
US10786507B2 (en) 2020-09-29
RU2744432C2 (ru) 2021-03-09
CN107530348A (zh) 2018-01-02
MX2018009741A (es) 2018-11-09
US20190030033A1 (en) 2019-01-31
KR20180109992A (ko) 2018-10-08
EP3417861A1 (en) 2018-12-26
JP2019505525A (ja) 2019-02-28
EP3417861B1 (en) 2020-09-23

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA.

B350 Update of information on the portal [chapter 15.35 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2710 DE 13-12-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.