BR112018014915A2 - polímeros à base de ciclodextrina, métodos, composições e aplicações dos mesmos - Google Patents

polímeros à base de ciclodextrina, métodos, composições e aplicações dos mesmos

Info

Publication number
BR112018014915A2
BR112018014915A2 BR112018014915-2A BR112018014915A BR112018014915A2 BR 112018014915 A2 BR112018014915 A2 BR 112018014915A2 BR 112018014915 A BR112018014915 A BR 112018014915A BR 112018014915 A2 BR112018014915 A2 BR 112018014915A2
Authority
BR
Brazil
Prior art keywords
methods
lipid
cyclodextrin
compositions
applications
Prior art date
Application number
BR112018014915-2A
Other languages
English (en)
Inventor
Kulkarni Aditya
Dolas Atul
Khurana Princy
Johny Soniya
Manjunath Manu
Original Assignee
Aten Porus Lifesciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aten Porus Lifesciences filed Critical Aten Porus Lifesciences
Publication of BR112018014915A2 publication Critical patent/BR112018014915A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

a presente revelação se refere a polímeros que compreendem conjugados de ciclodextrina ou derivados dos mesmos e a uma porção química ligante, métodos para preparar os mesmos e a aplicação dos mesmos na remoção de lipídios, tais como colesterol de células no tratamento de distúrbios de armazenamento de lipídio. os presentes polímeros exibem propriedades aprimoradas incluindo, porém sem limitação, biocompatibilidade aprimorada, tempo de retenção aprimorado, duração prolongada de uma ação nas células e eficácia aumentada na remoção de colesterol das células no tratamento de distúrbios de armazenamento de lipídio.
BR112018014915-2A 2016-01-21 2017-01-20 polímeros à base de ciclodextrina, métodos, composições e aplicações dos mesmos BR112018014915A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201641002350 2016-01-21
IN201641002350 2016-01-21
PCT/IB2017/050309 WO2017125889A1 (en) 2016-01-21 2017-01-20 Cyclodextrin based polymers, methods, compositions and applications thereof

Publications (1)

Publication Number Publication Date
BR112018014915A2 true BR112018014915A2 (pt) 2018-12-18

Family

ID=57966051

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018014915-2A BR112018014915A2 (pt) 2016-01-21 2017-01-20 polímeros à base de ciclodextrina, métodos, composições e aplicações dos mesmos

Country Status (12)

Country Link
US (1) US11447577B2 (pt)
EP (1) EP3405501B1 (pt)
JP (1) JP2019504178A (pt)
KR (1) KR20180104308A (pt)
CN (1) CN109153735A (pt)
AU (1) AU2017208939A1 (pt)
BR (1) BR112018014915A2 (pt)
CA (1) CA3011923A1 (pt)
IL (1) IL260679A (pt)
MX (1) MX2018008888A (pt)
RU (1) RU2018128032A (pt)
WO (1) WO2017125889A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017329084A1 (en) * 2016-09-19 2019-05-09 Aten Porus Lifesciences Cyclodextrin based polymers, methods, compositions and applications thereof
WO2020142716A1 (en) 2019-01-03 2020-07-09 Sens Research Foundation, Inc. Cyclodextrin dimers, compositions thereof, and uses thereof
CN113262767B (zh) * 2021-05-21 2022-05-20 南昌大学 苝二酰亚胺基桥联双β-环糊精固定相及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191101B (en) * 1983-02-14 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups
JPH03221505A (ja) * 1990-01-29 1991-09-30 Toppan Printing Co Ltd シクロデキストリンポリマーの合成方法及びシクロデキストリン膜の製造方法
JPH0586103A (ja) * 1990-10-01 1993-04-06 Toppan Printing Co Ltd シクロデキストリンポリマー
US6509323B1 (en) * 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
US7091192B1 (en) * 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
PT2277551E (pt) * 2002-09-06 2013-08-22 Cerulean Pharma Inc Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente
TW200640493A (en) * 2005-02-16 2006-12-01 Insert Therapeutics Inc Cyclodextrin-based polymers for therapeutics delivery
US20120004195A1 (en) 2010-01-19 2012-01-05 Alexandra Glucksmann Cyclodextrin-based polymers for therapeutic delivery
DE102010012282A1 (de) * 2010-03-22 2011-09-22 Fresenius Medical Care Deutschland Gmbh Pharmazeutische Zusammensetzung enthaltend Cyclodextrin-Copolymer
US20120302505A1 (en) 2011-04-21 2012-11-29 Fetzer Oliver S Cyclodextrin-based polymers for therapeutic delivery
JP2013233473A (ja) * 2012-05-02 2013-11-21 Neos Co Ltd シクロデキストリンポリマーを利用して媒体に含有されるハロゲン化芳香族化合物を選択的に吸着除去する方法
JP2015524444A (ja) * 2012-08-03 2015-08-24 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ライソゾーム蓄積症を治療するためのシクロデキストリン
WO2017006279A1 (en) 2015-07-08 2017-01-12 Aten Porus Lifesciences Cyclodextrin-polymer complexes and compostions and methods of making and using the same

Also Published As

Publication number Publication date
AU2017208939A1 (en) 2018-08-16
EP3405501A1 (en) 2018-11-28
EP3405501B1 (en) 2023-11-15
IL260679A (en) 2018-10-31
JP2019504178A (ja) 2019-02-14
WO2017125889A1 (en) 2017-07-27
KR20180104308A (ko) 2018-09-20
MX2018008888A (es) 2019-06-13
RU2018128032A (ru) 2020-02-25
US20210102006A1 (en) 2021-04-08
US11447577B2 (en) 2022-09-20
RU2018128032A3 (pt) 2020-05-19
CA3011923A1 (en) 2017-07-27
CN109153735A (zh) 2019-01-04

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements